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Compound antimicrobial containing polyvalent silver ions and preparation method thereof

A compound antibacterial agent, compound antibacterial technology, applied in the direction of antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of limited bactericidal ability, unsustainable bactericidal effect, weak anti-inflammatory effect, etc., to improve product stability, prevent The effect of viscosity reduction and long residence time

Inactive Publication Date: 2012-01-25
SHENZHEN HALDEX STC BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nano-silver can accumulate chronically in the human body due to its strong penetrating ability. Pure monovalent silver ion products have limited bactericidal ability and cannot deep-seed or quick-acting sterilize. Moreover, the above two types of silver products have weak anti-inflammatory effects and no Promote the regeneration of human epidermal cells, without the effect of enhancing the tissue's own defense function
[0003] Therefore, when the above-mentioned nano-silver antibacterial products and monovalent silver ion antibacterial products are used for gynecological diseases such as women's vaginitis and cervical erosion, and the treatment of infectious skin diseases, there is a high recurrence rate, especially for patients with intractable vaginitis. , chronic accumulation, bactericidal power is not durable, no deep sterilization and slow epithelial repair and other shortcomings
[0004] At present, there is still a lack of a non-antibiotic safe and environmentally friendly antibacterial product with strong and long-lasting bactericidal power, rapid sterilization, deep sterilization, strong anti-inflammatory effect, promotion of epithelial cell regeneration and no acute or chronic accumulation.

Method used

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  • Compound antimicrobial containing polyvalent silver ions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Carbomer 980 1g

[0019] Glycerin 15g

[0020] EDTA0.05g

[0021] Silver nitrate 0.2g

[0022] Silver peroxide 0.01g

[0023] Propylene glycol 10g

[0024] Chitosan oligosaccharide 1g

[0025] 1-Methylbenzotriazole 0.0001g

[0026] Citric acid 2g

[0027] Carmine 0.01g

[0028] Deionized water 70.7299g

[0029] Preparation method:

[0030] First add silver nitrate, 1-methylbenzotriazole, silver peroxide, and citric acid into deionized water in turn, and keep it in the dark for 30 minutes; then add EDTA, oligochitosan, propylene glycol, and carmine in turn , mix and stir gently until a pink aqueous solution is formed; gradually add Carbomer 980, keep it in the dark for 2 hours, and wait for it to fully swell; finally add glycerin and triethanolamine and mix well, adjust the pH value to 5-7, and use Stir with an overhead agitator at a speed of 450-500rpm; until a gel is formed, (viscosity reaches 30,000-50,000 centipoise), vacuumize and defoam (vacuum degree ≤-0...

Embodiment 2

[0032] EDTA0.05g

[0033] Silver nitrate 0.05g

[0034] Silver peroxide 0.01g

[0035]Propylene glycol 10g

[0036] Chitosan oligosaccharide 1g

[0037] 1-Methylbenzotriazole 0.0001g

[0038] Citric acid 2g

[0039] Carmine 0.01g

[0040] Deionized water 86.9799g

[0041] Preparation method:

[0042] First add silver nitrate, 1-methylbenzotriazole, silver peroxide, and citric acid into deionized water in turn, and keep it in the dark for 30 minutes; then add EDTA, propylene glycol, and carmine in turn, and mix gently , until a pink aqueous solution is formed, and packed into a finished compound antibacterial water preparation.

Embodiment 3

[0044] Carbomer 980 1g

[0045] Glycerin 15g

[0046] EDTA0.05g

[0047] Silver nitrate 0.2g

[0048] Silver peroxide 0.01g

[0049] Propylene glycol 10g

[0050] Chitosan Lactate 0.5g

[0051] 1-Methylbenzotriazole 0.0001g

[0052] Citric acid 2g

[0053] Carmine 0.01g

[0054] Mint 0.02g

[0055] borneol 0.02g

[0056] Deionized water 71.1899g

[0057] Preparation method:

[0058] First add silver nitrate, chitosan lactate, 1-methylbenzotriazole, citric acid, and silver peroxide into deionized water, and keep it in the dark for 30 minutes, then add EDTA, propylene glycol, and mint in sequence , borneol, and carmine to form a pink aqueous solution; gradually add Carbomer 980, keep it in the dark for 2 hours, and wait for it to fully swell; finally add glycerin and mix with an appropriate amount of triethanolamine until the pH reaches 5-7, and use the top Stir with a built-in agitator at a speed of 450-500rpm; until a gel is formed, (viscosity reaches 30,000-50,000...

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Abstract

The invention discloses a compound antimicrobial containing polyvalent silver ions, comprising a compound antibacterial gel preparation, a compound antibacterial water preparation and a compound antibacterial emulsifying preparation which are formed by respectively compounding an antibacterial reagent, a gel reagent, a water reagent and an emulsifying reagent. The antibacterial reagent contains amonovalent silver ion compound, a water soluble chitosan, EDTA, 1-methylbenzotriazole, propylene glycol and one or two of bivalent silver ion compound and trivalent silver ion compound. The inventionhas strong and lasting bacterial killing capability, can perform quick bacteria killing and deep bacteria killing, has strong anti-inflammatory function and the function on promoting the regenerationof epithelia, and can not generate acute or chronic accumulated toxic or side effect.

Description

technical field [0001] The invention relates to an antibacterial agent formula and its preparation, in particular to an antibacterial agent mainly containing complex polyvalent silver ions, water-soluble chitosan and EDTA and a preparation method thereof. Background technique [0002] Among the silver-related antibacterial products currently on the market, they can be classified according to the form of silver: there are two main types, one is nano-silver products, and the other is monovalent silver ion products. Nano-silver can accumulate chronically in the human body due to its strong penetrating ability. Pure monovalent silver ion products have limited bactericidal ability and cannot deep-seed or quick-acting sterilize. Moreover, the above two types of silver products have weak anti-inflammatory effects and no Promote the regeneration of human epidermal cells, but have no effect on enhancing the tissue's own defense function. [0003] Therefore, when the above-mentioned ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61K33/40A61P31/04A61P15/02A61P17/00A61K31/722
Inventor 沈作兵
Owner SHENZHEN HALDEX STC BIOLOGICAL ENG CO LTD
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