Application of praziquantel in preparing hepatic stellate cell activator-inhibitor

Abstract

The invention provides an application of praziquantel in preparing a hepatic stellate cell activator-inhibitor. The praziquantel can obviously inhibit the activation and the collagen secretion of hepatic stellate cells both in vivo and in vitro and cannot influence the multiplication capacity of spleen cells. The praziquantel can be used as an inhibitor for the activation of the hepatic stellate cells.

Description

Application of praziquantel in preparation of hepatic stellate cell activation inhibitor 1. Technical field The invention belongs to the field of medicine and provides praziquantel (2-cyclohexylformyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-α]isoquinoline- 4-keto, Praziquantel, PZQ) in the preparation of inhibitors of hepatic stellate cell activation. 2. Background technology Hepatic fibrosis is the post-injury repair response of the liver to chronic stimulation of various etiologies, characterized by excessive deposition of extracellular matrix (ECM) dominated by α1 (type I) collagen, which can further develop into cirrhosis , portal hypertension, liver failure, liver dysfunction. During liver injury, activated hepatic stellate cells (HSCs) are the main cells that produce collagen during liver fibrosis. After HSC activation, the enhanced cell proliferation ability and the increased synthesis of ECM components are the key to promoting fibrogenesis. The mechanism of HSC ...

AI Technical Summary

Problems solved by technology

Whether praziquantel can be used as an inhibitor of HSC activation, and whether it can be used as a drug against hepatic fibrosis in Schistosoma japonicum has not yet been studied

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