Inorganic nano hybrid material of nuclear-shell-type fluorescent-labeled magnetic medicine and preparation method thereof

A fluorescent labeling and inorganic nanotechnology, which is applied in the direction of pharmaceutical formulations, drug combinations, inorganic non-active ingredients, etc., to achieve the effect of delaying drug release

Inactive Publication Date: 2012-02-08
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the existing literature reports, there is no report based on ibuprofen-intercalated hydrotalcite core-shell fluorescently labeled magnetic nano-hybrid materials. This core-shell nano-hybrid material can not only control the release rate of ibuprofen, Avoid excessive drug release, improve its bioavailability, and also have a fluorescent tracer effect, and can achieve targeted positioning through an external magnetic field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification

[0027] Weigh 2.7093g FeCl 3 ·6H 2 O and 7.1832g CH3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .

[0028] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .

[002...

Embodiment 2

[0036] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification

[0037] Weigh 2.801g FeCl 3 ·6H 2 O and 7.1963g CH 3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .

[0038] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .

[00...

Embodiment 3

[0046] (1) Magnetic core Fe 3 o 4 Preparation of nanoparticles and their surface modification

[0047] Weigh 2.7893g FeCl 3 ·6H 2 O and 7.1923g CH 3 COONa·3H 2 O was dissolved in 80mL of ethylene glycol, transferred to a 100mL reactor lined with polytetrafluoroethylene, crystallized at 200°C for 10 hours, cooled to room temperature naturally, and washed with ethanol and deionized water for 2- 3 times, after magnetic separation, vacuum drying at 60°C for 24 hours to obtain a black powder, denoted as Fe 3 o 4 .

[0048] Weigh 0.1g Fe 3 o 4 Dissolve in 100mL alcohol-water mixed solution, ultrasonically disperse and transfer to a four-necked flask, add 25wt% ammonia water until the pH value is equal to 10, add 4mL tetraethyl orthosilicate dropwise, stir at 40°C for 12 hours, wash with ethanol and Wash with deionized water for 3-5 times, and dry at 60°C for 24 hours to obtain gray powder silicon dioxide-modified ferric iron tetroxide, denoted as Fe 3 o 4 -SiO 2 .

[0...

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Abstract

The invention relates to an inorganic nano hybrid material of a nuclear-shell-type fluorescent-labeled magnetic medicine and a preparation method thereof. In the invention, a magnetic substance is SiO2-modified Fe3O4, fluorescent quantum dots can be CdSe or CdTe, a model medicine is ibuprofen, a medicine carrier is Mg-Al hydrotalcite and a target product is an inorganic nano hybrid material of a nuclear-shell-type fluorescent-labeled magnetic medicine based on ibuprofen-intercalated Mg-Al hydrotalcite. The inorganic nano hybrid material of the nuclear-shell-type fluorescent-labeled magnetic medicine can be presented as Fe3O4-SiO2-QDs-SiO2@IBU-LDH and is prepared from the following components in percentage by weight: 70-80 percent of Fe2O3, 1-5 percent of QDs, 10-15 percent of SiO2 and 5-10 percent of IBU-LDH. The invention has the advantages that the inorganic nano hybrid material of the nuclear-shell-type fluorescent-labeled magnetic medicine based on the ibuprofen-intercalated Mg-Alhydrotalcite simultaneously has the functions of magnetic target positioning, fluorescent tracing, slow medicine release and the like. The structure, the composition, the magnetism magnitude, the fluorescent performance and the release velocity of the material can be effectively controlled by adjusting the mass ratio of Fe3O4-SiO2 to QDs to IBU-LDH.

Description

technical field [0001] The invention belongs to the technical field of hybrid materials, in particular to a core-shell fluorescently labeled magnetic drug inorganic nano-hybrid material and a preparation method. Background technique [0002] Semiconductor nanocrystals, also known as quantum dots, are aggregates of nanoscale atoms and molecules, generally with a particle size of about 1-10nm. This kind of quantum dots will produce a strong fluorescence effect when excited or applied with a voltage. Therefore, It can be widely used as a fluorescent probe in the fields of biomarkers and medical diagnosis. [0003] Fe 3 o 4 It is a ferromagnetic metal oxide with good magnetic responsiveness and can be oriented and concentrated under the induction of an external magnetic field, making this magnetic nanoparticle a potential research field in cell separation, immobilized enzymes, and oriented drugs. Application prospects, especially in the medical field, effectively combine magn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61P29/00A61P25/04A61K31/192A61K47/02A61K47/52
Inventor 张慧高艳张国彦盘登科
Owner BEIJING UNIV OF CHEM TECH
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