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Furanone compound Cytosporanone A having antibacterial activity

A compound, furanone technology, applied in the field of furanone compounds

Active Publication Date: 2011-12-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the isolation of a furanone compound Cytosporanone A with antibacterial activity from the endophytic fungus Cytospora sp.

Method used

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  • Furanone compound Cytosporanone A having antibacterial activity
  • Furanone compound Cytosporanone A having antibacterial activity
  • Furanone compound Cytosporanone A having antibacterial activity

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Embodiment 1. preparation compound Cytosporanone A

[0015] Take 18.73 g of endophytic fungus Cytospora sp. fermented product according to routine. Fermentations were provided by the University of Braunschweig, Germany. Dissolve the fermented product in 10ml of chloroform, separate by normal phase silica gel chromatography (200-300 mesh), and use methylene chloride: acetone volume ratio of 100:1, 80:20, 50:50, 30:70, 1:100 Gradient elution was carried out on the eluent of the fraction, and 18 fractions Fr 1 to Fr 18 were collected in total according to the polarity difference of each fraction according to the TLC monitoring. Part Fr 6 was separated and purified by normal phase silica gel chromatography (400-500 mesh), eluted with chloroform:methanol 20:1, and monitored by TLC to obtain 3 parts Fr 6.1-Fr 6.3. The Fr 6.3 part was purified by semi-preparative HPLC, using a mixed solvent with a volume ratio of methanol:water of 80:1 as the mobile phase, the detector was a...

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Abstract

The invention relates to the technical field of medicine, in particular to furanone compound Cytosporanone A which is separated from plant endophytic fungi Cytospora sp. leavening, has antibacterial activity and has the systematic name of (R)-5-((S)-hydroxy (phenyl)-methyl) dihydrofuran-2 (3H)-one, and the furanone compound Cytosporanone A has the chemical structural formula as follows. The in vitro antibacterial experiment proves that the compound Cytosporanone A has obvious bacteriostatic effect for botrytis cinerea, septoria musiva leaf blight fungi and bacillus megaterium, thus being used for preparing antibacterial medicines. The invention provides a lead compound for developing new antibacterial medicines, and has important valve for developing endophytic fungi medical resources of China.

Description

technical field [0001] The invention relates to a novel furanone compound Cytosporanone A with antibacterial activity isolated from the fermented product of the plant endophytic fungus Cytospora sp. Background technique [0002] Endophytic fungus is a class of fungi that exist in the stems and leaves of healthy plants and form insignificant infections. As the main microbial species, endophytic fungi have a large variety and quantity, and they distribute a wide range of host plants. The diversity of the micro-ecological system in which they live, coupled with the diversity of the ecological environment in which the host plants themselves live, so their secondary metabolites It also has rich diversity and can provide rich potential resources for the research of natural medicines. [0003] The endophytic fungus Cytospora sp. belongs to Deuteromycotina, Coelomycetes, Sphaeropsidales and Cytospora fungi. Cytospora sp. strain is isolated from Ilex canariensis, an evergreen shrub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/341C07D307/33A61P31/10A61P31/04
Inventor 易杨华李玲张文卢山孙鹏刘宝姝汤华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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