Optical bioluminescence tomography method

A bioluminescence, tomography technology, applied in the fields of diagnosis, medical science, diagnostic recording/measurement, etc., can solve the problem of unsolved quantitative mapping, etc.

Inactive Publication Date: 2011-01-19
XIDIAN UNIV
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Problems solved by technology

Furthermore, none of the existing bioluminescent tomography techniques has addressed the quantitative mapping of bioluminescent signals collected from CCD cameras to the energy distribution on the surface of living organisms.

Method used

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Embodiment Construction

[0064] The present invention will be further described below in conjunction with the accompanying drawings.

[0065] refer to figure 1 , the all-optical bioluminescent tomography method of the present invention comprises the following steps:

[0066] Step 1, data collection and preprocessing.

[0067] Collect bioluminescent signal images, control the imaging body to rotate at a certain angle at equal intervals, generally no more than 90° (90° is selected in this example), and use a CCD camera to collect no less than four bioluminescent signal images (four in this example). Continue to rotate to bring the imaging body back to the position where the bioluminescent signal image was originally acquired.

[0068] Collect white light signal images, control the imaging body to rotate at small angles at equal intervals, generally no more than 6° (3° in this example), use a CCD camera to collect no less than 60 white light signal images (120 in this example), and collect The white l...

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Abstract

The invention discloses an optical bioluminescence tomography method and solves the problem that the three-dimensional reconstruction can be realized by integrating structure imaging technology, such as computer tomography or magnetic resonance imaging. In the method, the three-dimensional profile of the surface of an organism is obtained by a white light signal image and is used for the inversion of the bioluminescence source in vivo by combining quantitive reconstruction of the energy distribution of the surface of the organism so as to implement a low-cost optical bioluminescence tomography process. The method comprises the following specific steps of: acquiring data and preprocessing; reconstructing the three-dimensional profile of the surface of the organism; reconstructing the energy distribution of the surface of the organism; performing quantitive calibration on the surface energy; and inverting the source in vivo and performing three-dimensional display. The optical bioluminescence tomography method has the characteristics of high sensitivity and low cost, saves complex, time and power-consuming segmentation and rectification links and can be used in the field of bioluminescence tomography.

Description

technical field [0001] The invention belongs to the technical field of optical molecular imaging, and relates to bioluminescent tomographic imaging technology, in particular to a bioluminescent tomographic imaging method based on all-optical data. Background technique [0002] Bioluminescence tomography is a non-contact optical molecular imaging technology emerging in recent years. The light transport model in tissue reconstructs the three-dimensional spatial position and concentration distribution of bioluminescent probes in small living animals, see GeWang, "Uniqueness theorems in bioluminescence tomography," Medical Physics 31, 2289-2299 (2004). In 2003, Professor Wang Ge of the University of Iowa proposed the concept of bioluminescence tomography for the first time, and developed a corresponding prototype system; the prototype system integrated computer tomography technology to provide the anatomical structure information of organisms, so it was named BLCT system , see ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
Inventor 梁继民陈雪利田捷屈晓超赵恒陈多芳侯彦宾朱守平高新波
Owner XIDIAN UNIV
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