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Method for preparing substrate for Chinese medicinal microemulsion paste patch

A technology of microemulsion and traditional Chinese medicine, which is applied in the direction of medical formula, medical preparations containing active ingredients, and ointment delivery, etc. It can solve problems such as unclear active ingredients, irritating absorption rate of the skin, and difficult to meet the requirements of preparation stability

Inactive Publication Date: 2013-12-25
河北康灵医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to the complex ingredients contained in traditional Chinese medicine, the active ingredients are not clear, and the crude extracts are mostly used as medicines. The solubility of fat-soluble drugs in the water phase in compound preparations is low, making it difficult for the stability of the preparations to meet the requirements. Skin irritation and low absorption rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of Bishoukang micro cream patch:

[0027] (1) The microemulsion matrix uses the following components by weight percentage: 10 ml of glycerin, 2 g of medical gelatin, 5 ml of propylene glycol, 3.5 ml of Tween-80, 0.5 g of sodium benzoate, 25 ml of magnolia liquid, 25 ml of coptis liquid, Distilled water 29ml

[0028] (2), the preparation method of microemulsion matrix:

[0029] (1) Soak the above-mentioned medical gelatin in water until it swells completely, add the above-mentioned glycerin and heat it on a water bath to dissolve;

[0030] (2) Remove from the hot water bath, add magnolia extract and coptis extract and stir quickly evenly, add 10 ml of traditional Chinese medicine extract each time, add in five times and mix well;

[0031] (3) Add the above-mentioned propylene glycol and the above-mentioned Tween-80 in sequence, mix thoroughly respectively, and add the above-mentioned sodium benzoate and distilled water;

[0032] (4) Adjust the p...

Embodiment 2

[0043] The preparation method of Erliqing micro-emulsion plaster:

[0044] (1) The microemulsion matrix uses the following components by weight percentage: glycerin 15 ml, medical gelatin 1 g, propylene glycol 6 ml, Tween-80 5 ml, sodium benzoate 0.5 g, asarum liquid 15 ml, chrysanthemum liquid 15 ml , Coptis liquid 20 ml, distilled water 22.5 ml.

[0045] (2), the preparation method of microemulsion matrix:

[0046] (1) Soak the above-mentioned medical gelatin in water until it swells completely, add the above-mentioned glycerin and heat it on a water bath to dissolve;

[0047] (2) Remove from the hot water bath, add asarum extract, chrysanthemum extract and coptis extract, stir quickly and evenly, add 10 ml of traditional Chinese medicine extract each time, that is, add in five times and mix well;

[0048] (3) Add the above-mentioned propylene glycol and the above-mentioned Tween-80 in sequence, mix thoroughly respectively, and add the above-mentioned sodium benzoate and d...

Embodiment 3

[0060] The preparation method of Yansuqing microemulsion patch:

[0061] (1) The microemulsion matrix adopts the following components by weight percentage: 20 g of glycerin, 1.5 g of medical gelatin, 4 g of propylene glycol, 4 g of Tween-80, 0.5 g of sodium benzoate, 15 ml of asarum liquid, and 15 ml of peppermint liquid , Coptis liquid 20 ml, distilled water 20 ml.

[0062] (2), the preparation method of microemulsion matrix:

[0063] (1) Soak the above-mentioned medical gelatin in water until it swells completely, add the above-mentioned glycerin and heat it on a water bath to dissolve;

[0064] (2) Remove from the hot water bath, add asarum liquid, peppermint liquid and coptis liquid and stir quickly evenly, add 10 ml of traditional Chinese medicine extract each time, add in five times and mix well;

[0065] (3) Add the above-mentioned propylene glycol and the above-mentioned Tween-80 in sequence, mix thoroughly respectively, and add the above-mentioned sodium benzoate an...

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Abstract

The invention relates to a method for preparing a substrate for a Chinese medicinal microemulsion paste patch. The substrate for the Chinese medicinal microemulsion paste patch is prepared by mixing two parts, namely a microemulsion substrate and a therapeutic medicament, wherein the therapeutic medicament can be prepared from any one or more of Chinese herbal medicines. The preparation method comprises the following steps of: preparing the microemulsion substrate and the therapeutic medicament successively, adding the microemulsion substrate into the therapeutic medicament according to a certain proportion, grinding in a grinder or a cream machine, pouring until the mixture has a bright surface and high liquidity and is non-viscous and non-granular, and putting into a storage device or cream spray tank for later use. By the method, the solubility of sparingly soluble volatile oil medicaments in a Chinese medicinal compound preparation is increased and the stability of the Chinese medicinal preparation and an ointment preparation is improved.

Description

technical field [0001] The invention relates to a preparation method for traditional Chinese medicine micro-emulsion patch. Background technique [0002] Due to the complex ingredients contained in traditional Chinese medicine, the active ingredients are not clear, and the crude extracts are mostly used as medicines. The solubility of fat-soluble drugs in the water phase in compound preparations is low, making it difficult to meet the requirements for the stability of the preparations. Skin irritant and low absorption rate. Contents of the invention [0003] The invention utilizes the characteristic that the microemulsion technology can simultaneously solubilize different fat-soluble drugs, and adopts a suitable method and matrix to make a new traditional Chinese medicine compound drug delivery system, which is applied to human acupuncture points or affected parts to exert therapeutic effect. [0004] The key of the present invention is that the microemulsion increases th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K9/10A61K9/06A61K36/00A61K47/42
Inventor 赵胜堂
Owner 河北康灵医药科技有限公司
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