Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs

A technology of anti-tumor drugs and bisflavone glycosides, applied in the directions of anti-tumor drugs, anti-viral agents, drug combinations, etc., can solve the problems of no research report and no retrieval of sophora bean bisflavonoid glycosides, and achieve anti-influenza efficacy. Excellent and strong anti-HBV effect and strong anti-HIV effect

Active Publication Date: 2011-03-02
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] There are no research reports on the application of alopecia glycosides in the preparation of antiviral and antitumor drugs at home and abroad, and no relevant literature has been retrieved

Method used

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  • Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Add 8 to 10 times the amount of water to the seeds or whole grass of Sophora sophora, extract twice at 80°C to 100°C, each time for 2 hours to 3 hours, filter, combine the filtrates and concentrate to obtain the concentrated crude extract solution; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, place the precipitate for 24 hours, filter the precipitate, concentrate and recycle the ethanol to obtain the concentrate; AB-8 macroporous resin on the concentrate Chromatographic column adsorption, wash the above-mentioned chromatographic column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the chromatographic column. The amount used is equivalent to 2 to 8 column volumes, the flow rate is 2 to 5 column volumes / hour, the ethanol eluents are collected and combined, concentrated at 50°C to 80°C, and the ethanol is recovered to o...

Embodiment 2

[0041] Example 2: add 8 to 10 times the amount of water to the seeds or whole grass of Sophora sophora, extract twice at 80°C to 100°C, for 2 hours to 3 hours each time, filter, combine the filtrates and concentrate to obtain the concentrated crude extract solution; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, place the precipitate for 24 hours, filter the precipitate, concentrate and recover the ethanol to obtain the concentrate; put the AB-8 macroporous resin on the concentrate Chromatographic column adsorption, wash the above-mentioned chromatographic column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the chromatographic column. The amount used is equivalent to 2 to 8 column volumes, the flow rate is 2 to 5 column volumes / hour, the ethanol eluents are collected and combined, concentrated at 50°C to 80°C, and the ethanol is recove...

Embodiment 3

[0042] Example 3: Add 8 to 10 times the amount of water to the seeds or whole grass of Sophora sophora, extract twice at 80°C to 100°C, for 2 hours to 3 hours each time, filter, combine the filtrates and concentrate to obtain the concentrated crude extract solution; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, place the precipitate for 24 hours, filter the precipitate, concentrate and recover the ethanol to obtain the concentrate; put the AB-8 macroporous resin on the concentrate Chromatographic column adsorption, wash the above-mentioned chromatographic column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the chromatographic column. The amount used is equivalent to 2 to 8 column volumes, the flow rate is 2 to 5 column volumes / hour, the ethanol eluents are collected and combined, concentrated at 50°C to 80°C, and the ethanol is recove...

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Abstract

The invention provides an anti-virus or/and anti-tumor drug and a preparation method thereof and an application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs. The invention provides the application of the chemical component fenugreek biflavone glycosides in fenugreek seeds as drugs for the first time, and uses the fenugreek biflavone glycosides for preparing anti-virus drugs and anti-tumor drugs for the first time. In vivo and in vitro experiment research shows that fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules of the invention have obvious effect on resisting influenza viruses, and the anti-influenza drug effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules of the invention is superior to the anti-influenza drug effect of the existing Western medicine ribavirin tablets. The anti-HBV effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-HBV effect of kurarinone capsules, and the anti-HIV effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-HIV effect of zidovudine tablets. The fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules have obvious effect on resisting proliferation of liver cancer, gastric cancer, intestinal cancer, lung cancer and cervical cancer cells, and the anti-tumor effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-tumor effect of the existing chemical component preparation hydroxycamptothecine injection.

Description

technical field [0001] The present invention relates to the technical field of the application of chemical components extracted and separated from plants as medicines, and is an antiviral or / and antitumor medicine and its preparation method, and the use of alopecia glycosides in the preparation of antiviral or / and antitumor medicines The present invention proposes for the first time the use of the chemical component alopecia glucoside in Sophora alopecuroides as medicine, and applies alopecia glycoside to the preparation of antiviral drugs and antitumor drugs for the first time. Background technique [0002] The incidence of viral infectious diseases is very high, and the mortality rate is also very high. Its spread not only causes serious social impact and economic losses, but also kills countless creatures like demons anytime and anywhere. Among the many viruses that have been discovered by human beings, the influenza virus can be called the oldest. Due to its high variabi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/12A61P35/00A61P31/16A61P31/18A61P31/20C07D407/14
Inventor 黄华王雪赵军王林林杨巧丽姚华史玉柱
Owner XINJIANG INST OF MATERIA MEDICA
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