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Method for sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus

A technology of Asarum radix and screening method, which is applied in the directions of medical preparations containing active ingredients, biochemical equipment and methods, plant/algae/fungus/moss components, etc., can solve problems such as unreported research and achieve good application Foreground effect

Inactive Publication Date: 2011-05-04
GUIYANG MEDICAL UNIVERSITY
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Problems solved by technology

However, there is no report on the active ingredients of Erigeron breviscapus for cranial nerve protection

Method used

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  • Method for sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus
  • Method for sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus
  • Method for sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus

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Embodiment Construction

[0025] Below in conjunction with specific embodiment, further illustrate the present invention.

[0026] 1 material

[0027] 1.1 Drugs and reagents Erigeron breviscapus (Vant.) hand-Mazz. The medicinal material of Erigeron breviscapus (Vant.) hand-Mazz. is identified by the Pharmacognosy Research Office of Guiyang Medical College in Huaxi District, Guiyang City; scutellarin, 3,5-dicaffeoyloxyquinic acid and chlorogenic acid were purchased from China National Institute of Pharmaceutical and Biological Products; , 5-dicaffeoyloxyquinic acid, etc. were provided by the School of Pharmacy, Guiyang Medical College (identified by H-NMR, C-NMR structure, HPLC normalized purity > 95%). Acetonitrile (chromatographically pure, American Tiandi Company); MCI GEL resin (CHP20P, Japan Mitsubishi Chemical). D-MEM culture medium was purchased from Gibco Invitrogen (UK); neuroblastoma cell lines (SH-SY5Y cells) derived from human brain were purchased from German Collection of Microorganisms a...

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Abstract

The invention relates to a sieving method of active ingredients of a traditional Chinese medicine, in particular provides a method for sieving active ingredients playing a protection role in cranial nerve from erigeron breviscapus. The method comprises the following steps of: dividing an erigeron breviscapus extract into components with different polarities by adopting a modern separation technology; forming a composition from the components according to different proportions; carrying out finger-print analysis and nerve cell damaged model protection role test on the composition, carrying out statistical treatment on finger-print chemical information and pharmacological activity information data, and sieving active ingredients and active components in erigeron breviscapus by utilizing finger-print pharmacology correlation research. The method can be used for rapidly, simply, conveniently and accurately sieving active ingredients playing protection role in cranial nerve from erigeron breviscapus, has the advantages of high sieving efficiency, lower cost and favorable application prospect and is expected to develop an effective drug for treating senile dementia by erigeron breviscapus through deep research.

Description

technical field [0001] The invention relates to a method for screening the activity of traditional Chinese medicines, and specifically provides a method for screening the active ingredients in Erigeron breviscapus with brain neuroprotective effect. Background technique [0002] Erigeron breviscapus (Vant.) hand-Mazz., also known as Erigeron breviscapus, is the dried whole herb of Compositae plant Erigeron breviscapus (Vant.) hand-Mazz. It is a single traditional Chinese medicine widely used in clinic. A lot of basic research has been done on the chemical composition and pharmacological activity of Erigeron breviscapine, and it is found that Asarum breviscapus and its extracts can expand coronary arteries, increase myocardial blood flow, reduce platelet accumulation, improve microcirculation, and improve angina pectoris of coronary heart disease; Improve the clinical symptoms of acute cerebral infarction, enhance the recovery of neurological function in patients with acute is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/50G01N30/86G01N33/15G01N33/68C12Q1/02A61K36/28
Inventor 王永林官志忠黄勇齐晓岚郑林兰燕宇王爱民李勇军何迅廖尚高傅晓钟周雯刘童
Owner GUIYANG MEDICAL UNIVERSITY
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