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Application of delta opioid receptor antagonist to relief of Alzheimer's disease

An Alzheimer's disease, opioid receptor technology, applied in the field of Alzheimer's disease treatment, to achieve the effects of relieving learning and memory impairment, reducing amyloid plaque pathology, and reducing shear activity

Inactive Publication Date: 2011-05-11
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

Although several subsequent studies did not verify the improvement of cognitive function of patients with naloxone or naltrexone, due to the limited means of diagnosis and monitoring of Alzheimer's disease at that time, this conclusion was mainly Derived from cognitive scales, may have limitations

Method used

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  • Application of delta opioid receptor antagonist to relief of Alzheimer's disease
  • Application of delta opioid receptor antagonist to relief of Alzheimer's disease
  • Application of delta opioid receptor antagonist to relief of Alzheimer's disease

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Embodiment Construction

[0039] One aspect of the present invention relates to the use of substances in the preparation of drugs for the treatment of Alzheimer's disease, the substances are selected from: (1) substances that inhibit the gene transcription, translation or expression of opioid receptors; (2) substances that inhibit opioid receptors (3) Substances that inhibit the transport of the complex formed by opioid receptors, β-secretase and γ-secretase.

[0040]The inventors have found through research that reducing the expression level of δ opioid receptor (DOR) in transgenic mice or blocking receptor signaling with DOR antagonists can significantly reduce the shearing of APP by BACE and γ-secretase. Cutting activity, thereby reducing the level of β-amyloid, alleviating the pathology of amyloid plaques, and alleviating the related learning and memory impairment. Meanwhile, DOR antagonist treatment did not affect the cleavage of other substrates such as Notch, cadherin and APLP by BACE and γ-secr...

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Abstract

The invention relates to application of a delta opioid receptor antagonist to the relief of Alzheimer's disease, in particular to application of a material to the preparation of a medicine for treating the Alzheimer's disease. The material is (1) a material for inhibiting the gene transcription, translation or expression of an opioid receptor, (2) a material for inhibiting the opioid receptor, beta-secretase and gamma-secretase from forming a complex, or (3) a material for inhibiting the complex formed by the opioid receptor, the beta-secretase and the gamma-secretase from being transferred.

Description

technical field [0001] The present invention relates to the treatment of Alzheimer's disease (Alzheimer's disease, AD), in particular to the application of a delta opioid receptor (DOR) antagonist or a kappa opioid receptor (KOR) antagonist to treat Alzheimer's disease . Background technique [0002] Alzheimer's disease is a degenerative disease of the central nervous system and one of the most important causes of dementia. Currently the most important hypothesis for the pathogenesis of Alzheimer's disease is the β-amyloid (Aβ) hypothesis. This hypothesis holds that Aβ, the main component of amyloid plaques, plays a fundamental role in the occurrence of Alzheimer's disease. Under the long-term effects of complex genetic and environmental factors, nerve cells abnormally produce a large amount of Aβ, which accumulates to form Aβ oligomers And amyloid plaques, Aβ directly or indirectly acts on neurons and glial cells through a series of cascade reactions (including free radic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K49/00A61P25/28
Inventor 裴钢赵简滕林
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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