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Petasites tatewakianus Kitam. extract as well as preparation method and application thereof
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A technology of butterbur and extract, applied in the field of medicine, can solve problems such as no separation, and achieve the effects of improving learning and memory functions, increasing the content of creatine kinase, and low cost
Inactive Publication Date: 2013-04-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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However, there have been no reports about the prevention and treatment of cardiovascular and cerebrovascular diseases, allergic rhinitis, tumors, senile dementia, depression, histamine and / or leukotriene components related to the extracts of butterbur palm leaf A report on the isolation of butterbur lactone Ⅶa from the extract of Butterbur
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Embodiment 1
[0015] Example 1. Preparation of Butterbur palmata extract.
[0016] The butterbur palm used is collected in the Northeast.
[0017] (1) 50kg of dried rhizomes of Butterbur palmata, crushed and extracted by percolation with 50% ethanol aqueous solution as usual, the extract was concentrated under reduced pressure to a non-alcoholic extract, then suspended in water to a volume of 50L, and then used separately 50 L of petroleum ether was extracted for 3 times, the petroleum ether extracts were combined, and concentrated under reduced pressure to obtain 9.6 kg of Butterbur palmata extract.
[0018] (2) 50 kg of dried rhizomes of Butterbur palmata, crushed and extracted by percolation with 95% ethanol aqueous solution as usual, the extract was concentrated under reduced pressure to an alcohol-free extract, then suspended in water to a volume of 50 L, and then used separately 50L of petroleum ether was extracted for 3 times, the petroleum ether extracts were combined, and concentr...
Embodiment 2
[0020] Embodiment 2. Preparation of butterbur lactone VIIa
[0021] Mix the sample with silica gel H (type 60, Qingdao Ocean Chemical Group Co., Ltd., the same below) with 7 g of the extract of Butterbur palmata prepared in (1) in Example 1, put it on the silica gel H chromatography column, and use petroleum ether: ethyl acetate Ester = 20:1-1:1 solvent system gradient elution, collect petroleum ether: ethyl acetate = 15:1 eluent, concentrate under reduced pressure, mix the sample with silica gel H, put on the silica gel H chromatography column, and use petroleum Ether: ethyl acetate = 30:1 Normal pressure and constant speed elution, sequentially obtain 150 mg of butterbur lactone, 30 mg of butterbur lactone-Ⅲa, 55 mg of butterbur lactone-Ⅳa; collect petroleum ether: ethyl acetate =8:1 eluent, concentrated under reduced pressure, mixed sample with silica gel H, put on silica gel H chromatography column, eluted with petroleum ether:ethyl acetate=20:1 normal pressure isocratic c...
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Abstract
The invention relates to the technical field of medicine, in particular to Petasites tatewakianus Kitam. extract and novel sesquiterpene lactone compound bakkenolide VIIa separated from the Petasites tatewakianus Kitam. extract. The chemical structural formula of the bakkenolide VIIa is as shown in the specification. Animal experiments and in vitro experiments prove that the Petasites tatewakianus Kitam. extract or bakkenolide VIIa has the activities of preventing cerebral isochemia, myocardial isochemia, allergic rhinitis, tumor, dysmnesia and the like, thus the Petasites tatewakianus Kitam.extract or the bakkenolide VIIa can be used for preparing medicaments capable of preventing heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and / or leukocyte component-related diseases. The preparation method is simple, and the cost is low; and the invention provides a novel medicament source for preventing the heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and / or leukocyte component-related diseases.
Description
technical field [0001] The present invention relates to the technical field of medicine, and relates to the extract of Butterbur palmata and the new sesquiterpene lactone compound Butterbur lactone VIIa isolated therefrom and their preparation and prevention of cardiovascular and cerebrovascular diseases, allergic rhinitis, tumors, Application in drugs for diseases related to Alzheimer's disease, depression, histamine and / or leukotriene components. Background technique [0002] Petasites tatewakianus Kitam. is a perennial herb, mainly distributed in the Xiaoxing'an Mountains and Changbai Mountains in Northeast my country, and also in the Far East of Russia and Sakhalin Island. [0003] Compositae butterbur plants are used as botanical medicines, and their rhizome extracts are used to treat migraine, urogenital spasm, asthma, allergic rhinitis, etc., and sesquiterpenoids are considered as their main active ingredients. However, there have been no reports about the prevention...
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