128 results about "Sesquiterpene lactone" patented technology

The invention relates to a sesquiterpene lactone compound and uses of a derivative thereof in preparation of drugs, belongs to the technical field of the drugs, specially relates to the uses of a formula (I) compound in preparation of the drugs, and particularly relates to the uses of a formula (I) compound in preparation of the drugs for treatment of rheumatoid arthritis and treatment of cancer through inhibition of cancer stem cells.

The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specificly have efficacy as treatments for hepatitis C viral infections.

The invention relates to a faked guaiane sesquiterpene lactone compound-Morgan blowball lactone A and the medicinable salt. The chemical name is 1-ketone-11(R)-hydroxyl-3, 5, 1(10)-trienin-faked lignum benedictum-8 alpha, 12-lactone. The compound could make medicine vehicle or medicine medicinal preparation with medicinable salt. The medicine contains other antibacterial druy. The preparation includes tablet, granule, capsule, oral liquid, drop pills, injection, skin penetrating agent, aerosol, etc. the compound could be used in medicine to prevent and cure anti gram positive fungus.

The invention discloses a method for extracting artemisinin. The method comprises the following steps: crushing leaf of Artemisia carvifolia; carrying out enzymatic hydrolysis in an aqueous solution, and carrying out pumping filtration after the enzymatic hydrolysis; carrying out low temperature extraction of the obtained filter cake by using an organic solvent, and concentrating the obtained extract liquid to obtain crude artemisinin; and recrystallizing the crude artemisinin to obtain purified artemisinin. Compared with traditional extraction methods and supercritical extraction methods, the method adopting an enzymatic hydrolysis-reflux two-step extraction technology in the invention has the advantages of simple process, less impurities, low apparatus requirements, and obviously increased extraction rate, and is an environmentally-friendly and efficient artemisinin extraction method. The method is also suitable for extracting sesquiterpene lactones in other medicinal plants.

The invention provides an inula wissmannian extract and preparation thereof and application in preparation of an antitumor drug. The extract is gemma alkane type sesquiterpene lactone inula wissmannian lactone methyl, ethyl, propyl, butyl and amyl or sheepear inula herb lactone. The extract has the following chemical structural formula and absolute configuration that: due to the toxicity killing function experiment of inula wissmannian lactone methyl, ethyl, propyl, butyl and amyl or sheepear inula herb lactone on human hepatoma cells HepG2, human prostatic cancer cells PC-3, human gastric carcinoma cells MGC-803, human leukemia cells K562, human nasopharynx cancer cells KB and normal human hepatocytes LO2, the result shows that the gemma alkane type sesquiterpene lactone has strong tumor cell killing function, and proliferation of tumor cells can be inhibited, so that the tumor cells are killed. The animal in-vivo experiment proves that the inula wissmannian plant extract and monomeric compounds have the anti-tumor effect and can serve as active ingredients for preparing the antitumor drug. A novel cancer treatment medicine is provided clinically, and high clinical application values and social benefits are generated.

The invention provides a preparation for inula wissmannian extracts and an application of the extracts in preparation of an anti-inflammatory medicine. The extracts are germacrane sesquiterpene lactone inula wissmannian lactones A, B, C, D and E and inula cappa lactone with the following chemical structural formulas and absolute configurations shown in the specification, wherein the inula wissmannian lactones A, B, C, D and E and the inula cappa lactone generate an inhibition effect on the NO of the RAW264.7 macrophage induced by LPS (lipopolysaccharide); and in an xylene-induced ear swelling mouse model and a Freund complete adjuvant arthritis rat model, the inula wissmannian lactones A, B, C, D and E and the inula cappa lactone are found to be able to obviously inhibit the ear swelling and foot swelling of experimental animals, and the result indicates that the inula wissmannian lactones A, B, C, D and E and the inula cappa lactone are good in anti-inflammatory activity, capable of being used for preparing an anti-inflammatory medicine, and great in application value. The invention provides an extraction and separation method for the inula wissmannian lactones A, B, C, D and E and the inula cappa lactone.

The invention discloses a sesquiterpene lactone compound, a preparation method thereof and an application of the sesquiterpene lactone compound in cancer treatment, and a structure of the sesquiterpene lactone compound is shown as a formula (I). The preparation method of the sesquiterpene lactone compound comprises the following steps: A) using an extraction solvent for extracting medicinal materials; B) concentrating an extract, adding water for suspending the extract, respectively using organic solvents having polarity from low to high for extracting a mixture to obtain an extract liquor, concentrating the extract liquor to obtain a crude extract; C) passing the crude extract through a normal-phase column, and eluting the crude extract with an eluting agent; collecting an eluent, and drying the eluent to obtain an extract product which is enriched with the novel sesquiterpene lactone compound; and D) performing reverse-phase medium-pressure column chromatography on the extract product and performing preparative high-efficiency liquid-phase column chromatography on a crude product to obtain the novel sesquiterpene lactone compound. The preparation method has the advantage of simple operation and low production cost; and the obtained product can be used for preparing cancer therapeutic drugs, and has favorable development prospects.

A method of preparing a chicory extract enriched with sesquiterpene lactones is provided. The method includes performing an initial extraction chicory in a polar solvent, such as methanol or ethanol, at ambient temperature to form an alcoholic extract. The alcoholic extract is subsequently defatted with a non-polar solvent, preferably hexane or n-heptane. A second extraction of the defatted alcoholic extract is performed with a solvent which is more polar than the solvent used in the defatting process and less polar than the solvent used in the initial extraction, for example, it can be chosen from the group consisting of ethyl acetate, n-butanol, isopropanol, n-propanol, dichloromethane, acetonitrile, and mixtures thereof; resulting in a sesquiterpene lactones enriched extract, preferably containing at least 60% sesquiterpene lactones.

The invention relates to the technical field of medicine, in particular to Petasites tatewakianus Kitam. extract and novel sesquiterpene lactone compound bakkenolide VIIa separated from the Petasites tatewakianus Kitam. extract. The chemical structural formula of the bakkenolide VIIa is as shown in the specification. Animal experiments and in vitro experiments prove that the Petasites tatewakianus Kitam. extract or bakkenolide VIIa has the activities of preventing cerebral isochemia, myocardial isochemia, allergic rhinitis, tumor, dysmnesia and the like, thus the Petasites tatewakianus Kitam.extract or the bakkenolide VIIa can be used for preparing medicaments capable of preventing heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and/or leukocyte component-related diseases. The preparation method is simple, and the cost is low; and the invention provides a novel medicament source for preventing the heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and/or leukocyte component-related diseases.

A process for extracting artemisinin features that the liquid-state CO2 is used as solvent to cyclically extracting artemisinin at 5-28 deg.C, and the obtained crude artemisinin has high purity.

The invention discloses a germacrane type sesquiterpene lactone compound, and a preparation method and application thereof. The germacrane type sesquiterpene lactone compound has structural formulas shown as formulas (I) to (IV). In the formulas (I) to (IV), R1 is H or OH; R2 is OH, OMeacr, or OEt; R3 is OAng, OH, or OMeacr; R4 is OTig or OAng; and R5 is CH2OH or CHO. The germacrane sesquiterpenelactone compound provided by the invention has an obvious differentiation inhibition effect on RANKL-induced osteoclasts, the IC50 of most of the compounds is 10.0 [mu]M or below, cytotoxicity is notshown under 10 [mu]M, and the germacrane sesquiterpene lactone can be applied to preparation of drugs for treating and/or preventing osteoporosis and has a good application prospect.

The invention discloses applications and a preparation method of saussurea total sesquiterpene lactone, belonging to the technical field of medicines and relating to the applications of the saussurea total sesquiterpene lactone in preparing antihypoxic drugs. The total sesquiterpene lactone can be extracted through a solvent method, a carbon dioxide supercritical extraction method and a petroleumether reflux method. Experiments find and prove that medicaments obtained in antihypoxic medicament preparation have significant antihypoxic effect. The preparation method provided by the invention is simple, and can be effectively used for extracting the total sesquiterpene lactone in saussurea.

The present invention relates to a Frangrant Ainsliaea Herb extract and active components, as well as the quality control method. The Frangrant Ainsliaea Herb extract contains sesquiterpene lactones in formula (1) and chlorogenic acids in formula (2). In formula (1), R1 is hydrogen or glucosyl group, R2 is hydrogen or hydroxyl and R3 is methane or methyl; R1, R2 and R3 can be freely combined in the respective selective group categories. In formula (2), R1, R2 and R3 can be coffeoyl or hydrogen. The above two components can be applied in the quality control of Frangrant Ainsliaea Herb medicinal material or the extract.

The invention discloses a pair of eudesmane sesquiterpene lactone epimers (1S,4S,5S,6S,7S,8S,9R,10S)-1,9-diacetoxy-4-hydroxy-6-isobutyryloxyprostatolide and (1S,4S,5R,6S,7S,8S,9R,10S)-1,9-diacetoxy-4-hydroxyl-6-isobutyryloxyprostatolide, pharmaceutically acceptable salts or solvates of the epimers, and pharmacodynamic activity of a pharmaceutical composition composed of the compounds, and mainly relates to a medical application of an anti-breast cancer medicine in inducing breast cancer cell MCF-7 cell morphology to retract and become round and the level of intracellular reactive oxygen species (ROS) to rise to show tumor cytotoxicity.

The invention discloses an ainsliatrimer B preparation method. In the preparation method, ainsliatrimer B is prepared from dehydrocostus lactone as a raw material mainly through oxidation reaction, Diels-alder reaction, and other steps, and the ainsliatrimer B is guaiacum lactone type sesquiterpenes lactone trimer, and can be extracted and separated from ainsliaea DC plant ainsliaea fulvioides. The study finds that the compound has certain inhibitory action on proliferation of human rectal cancer LOVO cells and human lung cancer A549 cells. The method is as follows: dehydrocostuslactone as a raw material, a compound (V) is obtained by 2 steps of reaction in the yield of 72.47%, then the ainsliatrimer B is prepared from the compound (V), the reaction process is greatly shortened, and the yield is raised.

The invention relates to the technical field of pharmaceutical chemistry, and concretely discloses an application of a sesquiterpene lactone compound in centipeda minima in preparation of a drug having antiviral effect. The sesquiterpene lactone compound is selected from one of arnicolide B, arnicolide D, and brevilin and a mixture of more than one of the above materials. The sesquiterpene lactonecompound has good antiviral effects for herpes simplex virus, hepatitis B virus, and human cytomegalovirus.

The invention relates to a muscular soreness relieving and massaging cream and a preparing method thereof. The muscular soreness relieving and massaging cream is prepared from various bioactive constituents including chavicol methylether, matricaria azulene, alpha-bisabol, sesquiterpene lactone, menthol, menthone, citral and the like. The muscular soreness relieving and massaging cream has the main effect of rejuvenating the musculoskeletal system, and has the functions of diminishing inflammation, relieving pain, recovering muscles, the brain, the heart and the elasticity of the skin and the like. The muscular soreness relieving and massaging cream is suitable for rheumatism, arthritis and muscular soreness. Essential oil of the muscular soreness relieving and massaging cream is prepared from essence extracted from plants, and is natural, organic, free of any artificially-synthesized constituent, free of removal of any original constituent, free of decloration, free of rectification and free of over oxidation. Thus, the muscular soreness relieving and massaging cream is free of toxic or side effects on the human body. In addition, due to the fact that chemical molecules are small and are lipid soluble molecules, the muscular soreness relieving and massaging cream can quickly seep into the corium layer or the blood capillary of the skin, and has the advantage of being fast in absorption. When the muscular soreness relieving and massaging cream is used, the skin is fine, moist and smooth. The product is convenient to carry and use and applicable to a wide range of objects.

The invention relates to an artemisinin preparation method. Novel sesquiterpene lactone containing a peroxide bridge is separated from sweet wormwood herb by adopting pressurizing countercurrent and reduced pressure evaporation separating means through an isothermal technology and an isobaric technology with a supercritical CO2 high pressure liquid as an extracting liquid. The artemisinin preparation method adopting the supercritical extraction technology and SC-CO2 extraction is an environmentally friendly method, and the above supercritical fluid has a same extraction capability with a liquid solvent, and also has an excellent mass transfer effect, so the use of a large amount of an organic solvent is avoided, and the harmfulness to the health of human bodies and the pollution to the environment in the extraction process are prevented. The artemisinin preparation method has the advantages of short extraction time, high extraction rate, energy saving, production cost saving and the like, and is suitable for large-scale industrial production.

The invention discloses an anti-cancer composition extracted from lindley eupatorium herb, and a preparation method and application thereof. The anti-cancer composition is separated from the lindley eupatorium herb by taking Eupalinolide G, Eupalinolide I and Eupalinolide J as main active components and sequentially using methods of percolation, normal-phase silica-gel column chromatography, reversed-phase medium-pressure column chromatography and the like. By using an MTT method and tests for humanized tumors and xenograft tumors in nude mice, in-vitro and in-vivo anti-breast cancer activities of three sesquiterpene lactone natural composition from the lindley eupatorium herb can be researched respectively. The result shows that the composition can be used for treating the breast cancer. The three sesquiterpene lactone natural composition from the lindley eupatorium herb, prepared by using the method, is high in biological activity, easy to operate and low in production cost, has the advantages of stable and controllable quality and the like, and can be used for preparing a medicine for treating the breast cancer.