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128 results about "Sesquiterpene lactone" patented technology
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Sesquiterpene lactones (SLs) are a class of sesquiterpenoids that contain a lactone ring. They are most often found in plants of the family Asteraceae (daisies, asters). Other plant families with SLs are Umbelliferae (celery, parsley, carrots) and Magnoliaciae (magnolias). A collection of colorless, lipophilic solids, SLs are a rich source of drugs. They can be allergenic and toxic in grazing livestock. Some are also found in corals such as Maasella edwardsi.
Total sesquiterpene lactone extract containing rich parthenolide and preparation method and application thereof
InactiveCN101190258AHigh in lactoneActive ingredients are clearOrganic chemistryAntineoplastic agentsTumor VirusOrganic solvent
The invention relates to a total sesquiterpene lactone extract containing rich parthenolide and the preparation method and application thereof. Particularly, the invention relates to a method of extracting sesquiterpene lactone containing rich parithenolide from yulan magnolia leaves and / or flower; yulan magnolia leaves and / or flower are taken as raw materials, crushed, extracted by polarity organic solvent and non-polarity organic solvent so as to get yulan magnolia total lactone; the yulan magnolia total lactone is processed with columnchromatography, and then the invention extract is obtained by collecting necessary components. The invention has definite effective components, the content of which is high, and is suitable for industrialized production. The invention has the anti-tumor virus function. The invention can be prepared into various pharmaceutical preparations with anti-tumor function.
Owner:BEIJING SUNHO PHARMA
Sesquiterpene lactone compound and uses of derivative thereof in preparation of drugs
The invention relates to a sesquiterpene lactone compound and uses of a derivative thereof in preparation of drugs, belongs to the technical field of the drugs, specially relates to the uses of a formula (I) compound in preparation of the drugs, and particularly relates to the uses of a formula (I) compound in preparation of the drugs for treatment of rheumatoid arthritis and treatment of cancer through inhibition of cancer stem cells.
Owner:ACCENDATECH LUOYANG CO LTD +1
Total sesquiterpene lactone extract of centipeda minima, preparation method and application thereof
InactiveCN101732383AInhibition of proliferative abilityInhibition of tumor proliferationOrganic active ingredientsOrganic chemistrySilica gelTumor cells
The invention provides a total sesquiterpene lactone extract of centipeda minima, a preparation method and application thereof. The preparation method comprises the following steps: crushing dried total centipeda minima, and extracting centipeda minima volatile oil by a supercritical carbon dioxide extracting method; and enriching the centipeda minima volatile oil through macroporous adsorption resin column chromatography or silica gel column chromatography to obtain the total sesquiterpene lactone extract of the centipeda minima. According to the method, the total sesquiterpene lactone with effect of inhibiting tumor proliferation is extracted from Chinese medicament centipeda minima and is enriched for the first time; the extract is rich in short-leaf geraniin; the extract contains at least nine sesquiterpene lactone compounds, wherein the angelic acid centipeda minima and the isobutyric acid centipeda minima are new active sesquiterpene lactone compounds; by the preparation method, the yield is high; the method is suitable for industrialized production; and the extract has the effect of inhibiting tumor cell proliferation, and can be used for preparing various medicaments or health-care products with anti-tumor effect.
Owner:JINAN UNIVERSITY
Applications of sesquiterpene lactone compound and derivative of sesquiterpene lactone compound in treatment of diabetes
The invention relates to applications of a sesquiterpene lactone compound and a derivative of the sesquiterpene lactone compound in treatment of diabetes, belongs to the technical field of medicine, and specifically relates to applications of a compound represented by formula (I) in prevention, therapy or adjuvant therapy of diabetes and diabetic chronic complications, and in preparation of medicines used for prevention, therapy or adjuvant therapy of the diabetes and diabetic chronic complications.
Owner:龙海波
Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2
InactiveUS6908630B2Relieve symptomsIncrease ratingsBiocidePeptide/protein ingredientsEtiologyCyclooxygenase
A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component of a sesquiterpene lactone species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
Owner:METAPROTEOMICS
Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
InactiveUS20050059647A1Useful in treatmentBiocidePeptide/protein ingredientsAbnormal tissue growthBovine Viral Diarrhea Viruses
The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specificly have efficacy as treatments for hepatitis C viral infections.
Owner:KEMIN FOODS L C
Sesquiterplactone in dandelion and its use of resisting Gram's positive bacteria
The invention relates to a faked guaiane sesquiterpene lactone compound-Morgan blowball lactone A and the medicinable salt. The chemical name is 1-ketone-11(R)-hydroxyl-3, 5, 1(10)-trienin-faked lignum benedictum-8 alpha, 12-lactone. The compound could make medicine vehicle or medicine medicinal preparation with medicinable salt. The medicine contains other antibacterial druy. The preparation includes tablet, granule, capsule, oral liquid, drop pills, injection, skin penetrating agent, aerosol, etc. the compound could be used in medicine to prevent and cure anti gram positive fungus.
Owner:ZHEJIANG UNIV
Method for extracting artemisinin through enzymatic hydrolysis
InactiveCN103304576AEfficient removalHigh purityOrganic chemistryBulk chemical productionArtemisia carvifoliaTwo step
The invention discloses a method for extracting artemisinin. The method comprises the following steps: crushing leaf of Artemisia carvifolia; carrying out enzymatic hydrolysis in an aqueous solution, and carrying out pumping filtration after the enzymatic hydrolysis; carrying out low temperature extraction of the obtained filter cake by using an organic solvent, and concentrating the obtained extract liquid to obtain crude artemisinin; and recrystallizing the crude artemisinin to obtain purified artemisinin. Compared with traditional extraction methods and supercritical extraction methods, the method adopting an enzymatic hydrolysis-reflux two-step extraction technology in the invention has the advantages of simple process, less impurities, low apparatus requirements, and obviously increased extraction rate, and is an environmentally-friendly and efficient artemisinin extraction method. The method is also suitable for extracting sesquiterpene lactones in other medicinal plants.
Owner:ARMY MEDICAL UNIV
Health article containing lindera leaf extract and its preparing method
The present invention relates to health article containing sesquiterpene lactone and flavonol extracted from lindera leaf and other components and its preparation process. The health article contains lindera leaf extract in 15-20 wt% and the other components from buffalo horn, oriental water plantain, fleeceflower root, haw, cassia seed and other six kinds of Chinese medicinal materials in 80-85 wt%. The preparation process includes reflux extracting lindera leaf powder with organic solvent and other steps to obtain lindera leaf extract; extracting the other 11 kinds of Chinese medicinal materials in different methods to obtain medicine extract; and mixing in certain weight ratio. The health article possesses functions of preventing cardiac and cerebral vascular diseases, eliminating toxin, nursing face, regulating blood fat, blood sugar and blood pressure, and protecting liver against chemical damage. It is especially suitable for middle-aged people and old people.
Owner:陈方标
Inula wissmannian extract and preparation thereof and application in preparation of antitumor drug
The invention provides an inula wissmannian extract and preparation thereof and application in preparation of an antitumor drug. The extract is gemma alkane type sesquiterpene lactone inula wissmannian lactone methyl, ethyl, propyl, butyl and amyl or sheepear inula herb lactone. The extract has the following chemical structural formula and absolute configuration that: due to the toxicity killing function experiment of inula wissmannian lactone methyl, ethyl, propyl, butyl and amyl or sheepear inula herb lactone on human hepatoma cells HepG2, human prostatic cancer cells PC-3, human gastric carcinoma cells MGC-803, human leukemia cells K562, human nasopharynx cancer cells KB and normal human hepatocytes LO2, the result shows that the gemma alkane type sesquiterpene lactone has strong tumor cell killing function, and proliferation of tumor cells can be inhibited, so that the tumor cells are killed. The animal in-vivo experiment proves that the inula wissmannian plant extract and monomeric compounds have the anti-tumor effect and can serve as active ingredients for preparing the antitumor drug. A novel cancer treatment medicine is provided clinically, and high clinical application values and social benefits are generated.
Owner:SHANGHAI JIAO TONG UNIV
Wedelia trilobata anti-tumor extract and preparation and application methods thereof
ActiveCN107522680AClarify chemical compositionGood antitumor activityCarboxylic acid amide separation/purificationSteroidsDipeptideEthyl acetate
The invention discloses a wedelia trilobata anti-tumor extract and preparation and application methods thereof. The wedelia trilobata anti-tumor extract is prepared by adding solvent into wedelia trilobata powder for extraction, filtering and decompression-concentrating extracted liquor to obtain a total extract, mixing the total extract with water into a suspension, performing extraction sequentially through petroleum ether and ethyl acetate and performing decompressed recovery to obtain a petroleum ether solution, an ethyl acetate solution and a aqueous solution, wherein the petroleum ether solution contains one eudesmene type sesquiterpene lactone, five enantiotopic kaurane type diterpenoid compounds, two oleanane type triterpenes, one cycloartane type triterpene, one sterol compound, two dipeptide compounds and one caffeate compound. The prepared wedelia trilobata anti-tumor extract is high in yield, simple in technical process, low in cost and applicable to large-scale preparation, and meanwhile, has broad-spectrum anti-tumor activity and can serve as an active component applied to tumor control and treatment drugs.
Owner:HAINAN NORMAL UNIV
Inula wissmannian extracts, preparation for same, and application of extracts in preparation of anti-inflammatory medicine
Owner:SHANGHAI JIAO TONG UNIV
Sesquiterpene lactone compound, preparation method and application thereof
ActiveCN105294623ANovel structureThe preparation method is scientific and reasonableOrganic active ingredientsOrganic chemistryOrganic solventSolvent
The invention discloses a sesquiterpene lactone compound, a preparation method thereof and an application of the sesquiterpene lactone compound in cancer treatment, and a structure of the sesquiterpene lactone compound is shown as a formula (I). The preparation method of the sesquiterpene lactone compound comprises the following steps: A) using an extraction solvent for extracting medicinal materials; B) concentrating an extract, adding water for suspending the extract, respectively using organic solvents having polarity from low to high for extracting a mixture to obtain an extract liquor, concentrating the extract liquor to obtain a crude extract; C) passing the crude extract through a normal-phase column, and eluting the crude extract with an eluting agent; collecting an eluent, and drying the eluent to obtain an extract product which is enriched with the novel sesquiterpene lactone compound; and D) performing reverse-phase medium-pressure column chromatography on the extract product and performing preparative high-efficiency liquid-phase column chromatography on a crude product to obtain the novel sesquiterpene lactone compound. The preparation method has the advantage of simple operation and low production cost; and the obtained product can be used for preparing cancer therapeutic drugs, and has favorable development prospects.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
In vitro and in vivo Anti-inflammatory effects of a sesquiterpene lactone extract from chicory (cichorium intybus l.)
ActiveUS20070098827A1Reduce inflammationOrganic active ingredientsBiocideCichoriumAscophyllum nodosum extract
A method of preparing a chicory extract enriched with sesquiterpene lactones is provided. The method includes performing an initial extraction chicory in a polar solvent, such as methanol or ethanol, at ambient temperature to form an alcoholic extract. The alcoholic extract is subsequently defatted with a non-polar solvent, preferably hexane or n-heptane. A second extraction of the defatted alcoholic extract is performed with a solvent which is more polar than the solvent used in the defatting process and less polar than the solvent used in the initial extraction, for example, it can be chosen from the group consisting of ethyl acetate, n-butanol, isopropanol, n-propanol, dichloromethane, acetonitrile, and mixtures thereof; resulting in a sesquiterpene lactones enriched extract, preferably containing at least 60% sesquiterpene lactones.
Owner:RUTGERS THE STATE UNIV
Method for preparing total elecampane sesquiterpene lactone extract
InactiveCN102526150AHigh in lactoneHigh yieldAntibacterial agentsAntimycoticsChromatographic separationAdditive ingredient
The invention provides a method for preparing total elecampane sesquiterpene lactone extract. The method comprises the following steps: smashing dried elecampane roots, extracting solution through polar organic solvent, adding 1-3% of activated carbon to decolorize extracted solution, performing filtering and pressure reduction to recover reagent, concentrating the reagent to have alcohol content lower than 10%, using nonpolar organic solvent to perform extraction and obtain total elecampane lactone, performing polyamide resin column chromatographic separation to collect required ingredients and obtaining the total elecampane sesquiterpene lactone extract. The total elecampane sesquiterpene lactone extract contains elecampane lactone and isoalantolactone lactone, preparation process yield is high, active ingredients are clear and definite, and the total elecampane sesquiterpene lactone extract is suitable for industrialized production.
Owner:苏州宝泽堂医药科技有限公司
Uses of sesquiterpene lactone compounds and their derivatives in drugs preparation
ActiveUS20160367525A1Organic chemistryHeterocyclic compound active ingredientsMedicineDrugs preparations
The present invention relates to the uses of sesquiterpene lactone compounds and their derivatives in preparing drugs. It belongs to the field of drug technology, specifically relates to the uses of the compounds of Formula (I) in preparing the drugs, especially the uses in preparing the drugs to treat rheumatoid arthritis and treat cancers through inhibiting cancer stem cells.
Owner:ACCENDATECH +1
Petasites tatewakianus Kitam. extract as well as preparation method and application thereof
InactiveCN102086182ABoosts Creatine Kinase LevelsHas a preventive effectOrganic active ingredientsNervous disorderDiseaseStructural formula
The invention relates to the technical field of medicine, in particular to Petasites tatewakianus Kitam. extract and novel sesquiterpene lactone compound bakkenolide VIIa separated from the Petasites tatewakianus Kitam. extract. The chemical structural formula of the bakkenolide VIIa is as shown in the specification. Animal experiments and in vitro experiments prove that the Petasites tatewakianus Kitam. extract or bakkenolide VIIa has the activities of preventing cerebral isochemia, myocardial isochemia, allergic rhinitis, tumor, dysmnesia and the like, thus the Petasites tatewakianus Kitam.extract or the bakkenolide VIIa can be used for preparing medicaments capable of preventing heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and / or leukocyte component-related diseases. The preparation method is simple, and the cost is low; and the invention provides a novel medicament source for preventing the heart cerebrovascular diseases, allergic rhinitis, tumor, senile dementia, tristimania, histamine and / or leukocyte component-related diseases.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Method of extracting qinghaosu
A process for extracting artemisinin features that the liquid-state CO2 is used as solvent to cyclically extracting artemisinin at 5-28 deg.C, and the obtained crude artemisinin has high purity.
Owner:WUHU TALENT NATURAL EXTRACT
Germacrane type sesquiterpene lactone compound, and preparation method and application thereof
ActiveCN112159378AInhibition of differentiationInhibition of differentiation effectOrganic active ingredientsOrganic chemistry methodsRANKLOsteocyte
The invention discloses a germacrane type sesquiterpene lactone compound, and a preparation method and application thereof. The germacrane type sesquiterpene lactone compound has structural formulas shown as formulas (I) to (IV). In the formulas (I) to (IV), R1 is H or OH; R2 is OH, OMeacr, or OEt; R3 is OAng, OH, or OMeacr; R4 is OTig or OAng; and R5 is CH2OH or CHO. The germacrane sesquiterpenelactone compound provided by the invention has an obvious differentiation inhibition effect on RANKL-induced osteoclasts, the IC50 of most of the compounds is 10.0 [mu]M or below, cytotoxicity is notshown under 10 [mu]M, and the germacrane sesquiterpene lactone can be applied to preparation of drugs for treating and / or preventing osteoporosis and has a good application prospect.
Owner:SUN YAT SEN UNIV
Applications and preparation method of saussurea total sesquiterpene lactone
The invention discloses applications and a preparation method of saussurea total sesquiterpene lactone, belonging to the technical field of medicines and relating to the applications of the saussurea total sesquiterpene lactone in preparing antihypoxic drugs. The total sesquiterpene lactone can be extracted through a solvent method, a carbon dioxide supercritical extraction method and a petroleumether reflux method. Experiments find and prove that medicaments obtained in antihypoxic medicament preparation have significant antihypoxic effect. The preparation method provided by the invention is simple, and can be effectively used for extracting the total sesquiterpene lactone in saussurea.
Owner:中国人民解放军联勤保障部队第九四〇医院
Ainsliaea fragrans extract and active component thereof as well as their quality control method
The present invention relates to a Frangrant Ainsliaea Herb extract and active components, as well as the quality control method. The Frangrant Ainsliaea Herb extract contains sesquiterpene lactones in formula (1) and chlorogenic acids in formula (2). In formula (1), R1 is hydrogen or glucosyl group, R2 is hydrogen or hydroxyl and R3 is methane or methyl; R1, R2 and R3 can be freely combined in the respective selective group categories. In formula (2), R1, R2 and R3 can be coffeoyl or hydrogen. The above two components can be applied in the quality control of Frangrant Ainsliaea Herb medicinal material or the extract.
Owner:上海中创医药科技有限公司
Application of eudesmane sesquiterpene lactone epimers in preparation of anti-breast cancer medicine
The invention discloses a pair of eudesmane sesquiterpene lactone epimers (1S,4S,5S,6S,7S,8S,9R,10S)-1,9-diacetoxy-4-hydroxy-6-isobutyryloxyprostatolide and (1S,4S,5R,6S,7S,8S,9R,10S)-1,9-diacetoxy-4-hydroxyl-6-isobutyryloxyprostatolide, pharmaceutically acceptable salts or solvates of the epimers, and pharmacodynamic activity of a pharmaceutical composition composed of the compounds, and mainly relates to a medical application of an anti-breast cancer medicine in inducing breast cancer cell MCF-7 cell morphology to retract and become round and the level of intracellular reactive oxygen species (ROS) to rise to show tumor cytotoxicity.
Owner:HAINAN NORMAL UNIV
Ainsliatrimer B preparation method
InactiveCN104311572AFew reaction stepsSolve the shortcomings of low yield, many steps and low yieldOrganic chemistryAinsliatrimer BA549 cell
The invention discloses an ainsliatrimer B preparation method. In the preparation method, ainsliatrimer B is prepared from dehydrocostus lactone as a raw material mainly through oxidation reaction, Diels-alder reaction, and other steps, and the ainsliatrimer B is guaiacum lactone type sesquiterpenes lactone trimer, and can be extracted and separated from ainsliaea DC plant ainsliaea fulvioides. The study finds that the compound has certain inhibitory action on proliferation of human rectal cancer LOVO cells and human lung cancer A549 cells. The method is as follows: dehydrocostuslactone as a raw material, a compound (V) is obtained by 2 steps of reaction in the yield of 72.47%, then the ainsliatrimer B is prepared from the compound (V), the reaction process is greatly shortened, and the yield is raised.
Owner:CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
In vitro and in vivo anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.)
ActiveUS7226623B2Reduce inflammationBiocideOrganic active ingredientsCichoriumAscophyllum nodosum extract
Owner:RUTGERS THE STATE UNIV
Application of sesquiterpene lactone compound in centipeda minima in preparation of drug having antiviral effect
InactiveCN108743583AGood antiviral effectOrganic active ingredientsAntiviralsMedicineHepatitis B virus
The invention relates to the technical field of pharmaceutical chemistry, and concretely discloses an application of a sesquiterpene lactone compound in centipeda minima in preparation of a drug having antiviral effect. The sesquiterpene lactone compound is selected from one of arnicolide B, arnicolide D, and brevilin and a mixture of more than one of the above materials. The sesquiterpene lactonecompound has good antiviral effects for herpes simplex virus, hepatitis B virus, and human cytomegalovirus.
Owner:JINAN UNIVERSITY
Muscular soreness relieving and massaging cream and preparing method thereof
The invention relates to a muscular soreness relieving and massaging cream and a preparing method thereof. The muscular soreness relieving and massaging cream is prepared from various bioactive constituents including chavicol methylether, matricaria azulene, alpha-bisabol, sesquiterpene lactone, menthol, menthone, citral and the like. The muscular soreness relieving and massaging cream has the main effect of rejuvenating the musculoskeletal system, and has the functions of diminishing inflammation, relieving pain, recovering muscles, the brain, the heart and the elasticity of the skin and the like. The muscular soreness relieving and massaging cream is suitable for rheumatism, arthritis and muscular soreness. Essential oil of the muscular soreness relieving and massaging cream is prepared from essence extracted from plants, and is natural, organic, free of any artificially-synthesized constituent, free of removal of any original constituent, free of decloration, free of rectification and free of over oxidation. Thus, the muscular soreness relieving and massaging cream is free of toxic or side effects on the human body. In addition, due to the fact that chemical molecules are small and are lipid soluble molecules, the muscular soreness relieving and massaging cream can quickly seep into the corium layer or the blood capillary of the skin, and has the advantage of being fast in absorption. When the muscular soreness relieving and massaging cream is used, the skin is fine, moist and smooth. The product is convenient to carry and use and applicable to a wide range of objects.
Owner:SHANGHAI UNIV
Artemisinin preparation method
InactiveCN104140433ATotal Manufacturing Cost ReductionReduce extraction timeOrganic chemistryBulk chemical productionEvaporationSolvent
The invention relates to an artemisinin preparation method. Novel sesquiterpene lactone containing a peroxide bridge is separated from sweet wormwood herb by adopting pressurizing countercurrent and reduced pressure evaporation separating means through an isothermal technology and an isobaric technology with a supercritical CO2 high pressure liquid as an extracting liquid. The artemisinin preparation method adopting the supercritical extraction technology and SC-CO2 extraction is an environmentally friendly method, and the above supercritical fluid has a same extraction capability with a liquid solvent, and also has an excellent mass transfer effect, so the use of a large amount of an organic solvent is avoided, and the harmfulness to the health of human bodies and the pollution to the environment in the extraction process are prevented. The artemisinin preparation method has the advantages of short extraction time, high extraction rate, energy saving, production cost saving and the like, and is suitable for large-scale industrial production.
Owner:TIANJIN V SENT MEDICINE TECH
Sesquiterpene lactone compounds, preparation method thereof and application to preparation of NPC (nasopharyngeal carcinoma) preventing and treating drugs
ActiveCN110563679AGood control effectSecurity ConfirmationOrganic active ingredientsOrganic chemistryAbnormal tissue growthPositive control
The invention discloses sesquiterpene lactone compounds, a preparation method thereof and an application to preparation of NPC (nasopharyngeal carcinoma) preventing and treating drugs. The structuralformula of the sesquiterpene lactone compounds is presented as the formula (I); and the sesquiterpene lactone compounds have higher anti-NPC activity, IC50 of the most compounds is 10.0 [mu] M or lower, and particularly, IC50 of the anti-NPC activity of the compound XF2-30 reaches 0.40 [mu] M. The efficacy evaluation for the compounds shows that the compounds inhibit NPC proliferation, promote carcinoma cell apoptosis, induce autophagy and have an obvious inhibition effect on migration and invasion of NPC cells. In a transplantation tumor experiment of a NPC nude mouse, the inhibition ratio reaches 53% under the dosage of 7.5 mg / kg and is comparable with that of positive control cis-platinum (under the dosage of 5 mg / kg), an in-vivo safety experiment also confirms safety of the compounds,and the compounds can be applied to preparation of the NPC preventing and treating drugs.
Owner:SUN YAT SEN UNIV
Applications and preparation method of saussurea total sesquiterpene lactone
Owner:中国人民解放军联勤保障部队第九四〇医院
Anti-cancer composition extracted from lindley eupatorium herb, and preparation method and application thereof
InactiveCN107243005AImprove biological activityActive substance is clearOrganic active ingredientsAntineoplastic agentsSilica gelDrug biological activity
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
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