12 results about "Sesquiterpene lactone" patented technology

This document discloses a method for generating intermediates in the total synthesis of (+)-daunoglobin or its derivatives, and the total synthesis of (+)-daunoglobin or its derivatives. This document also discloses methods for forming compounds of formula XIV and XV, wherein compounds of formula XIV and XV are as defined in the specification.

This application discloses the use of artesunate in the preparation of drugs for enhancing the therapeutic effect of PARP inhibitors, belonging to the field of biomedical technology. The artesunate described in this application is a sesquiterpene lactone derivative extracted from the traditional Chinese medicine Artemisia annua. It has an inhibitory effect on the proliferation of BRCA wild-type ovarian cancer cells and low toxicity to normal human ovarian epithelial cells. This application's research found that artesunate can enhance the DNA damage and apoptosis induced by PARP inhibitors (such as olaparib, niraparib, and rucaparib), and improve the sensitivity of PARP inhibitors to BRCA wild-type ovarian cancer.

The invention relates to the field of medicinal chemistry, relates to a guaiane sesquiterpene lactone compound as well as a preparation method and application thereof, and in particular relates to a guaiane sesquiterpene lactone compound which is a compound 1 to a compound 8, a preparation method of the guaiane sesquiterpene lactone compound and medical application of the guaiane sesquiterpene lactone compound in preparation of medicines for preventing or treating inflammatory diseases. Furthermore, two compounds (a compound 5 and a compound 8) with remarkable anti-inflammatory activity are rapidly screened by using an LPS-induced RAW264.7 cell inflammation model, the structure is novel, the synthesis method is simple and convenient, and an excellent anti-inflammatory effect is shown in an in-vitro model. Compared with the existing anti-inflammatory drugs, the compound has the potential of becoming a new generation of anti-inflammatory drugs, and can be used as a lead compound to develop a novel anti-inflammatory drug.

The application discloses a marine-derived compound Cpd-8 and application thereof in preparation of a medicine for resisting TNF-induced cell death. Through screening of an extract library of marine-derived sponge symbiotic fungi of a research group, a small-molecule inhibitor with a novel structure is obtained, which can resist TNF-induced cell death, and specifically, the marine-derived sesquiterpene lactone nitrobenzene analogue Cpd-8 and a pharmaceutically acceptable salt thereof. The compound can inhibit TNF-induced cell death and formation of a complex II in a signal pathway, thereby exerting an anti-cell death activity. In-vitro cell experiment results show that the compound of the application can significantly inhibit TNF-induced cell death. In-vivo animal experiment results show that the compound of the application can inhibit TNF-alpha / D-GaIN (D-galactosamine)-induced acute liver injury, and significantly prolong the survival period of mice.

This invention belongs to the field of traditional Chinese medicine pharmaceutical technology, specifically relating to the use of loliolide, a sesquiterpene compound, in the treatment of viral pneumonia. The invention isolates and extracts loliolide from *Lysimachia christinae*. Whole-animal experiments have confirmed that this compound has a good therapeutic effect on H1N1 influenza A virus-induced viral pneumonia in mice, significantly improving body weight, lung index, lung inflammation, viral titer, and pathological changes in virus-infected mice. Loliolide can be further used to prepare new drugs for the treatment of viral pneumonia.

The application relates to the technical field of medicines, in particular to a sesquiterpene lactone compound in the fruit of Styrax pubescens, an extraction method and application thereof. A sesquiterpene lactone compound CA50 is extracted from the fruit of Styrax pubescens, and the structure is shown as formula I. The preliminary experiment verifies that the CA50 can reduce the levels of HBV core DNA and HBsAg in HepAD38 cells, and has the potential to prepare anti-hepatitis B virus drugs.

The application belongs to the technical field of biological medicine, and particularly relates to application of a sesquiterpene lactone compound in preparation of an antiviral drug. The sesquiterpene lactone compound has a significant inhibitory effect on bunyaviruses, and the effect is equivalent to that of a positive control, so that the sesquiterpene lactone compound has a good application prospect in preparation of antiviral drugs. In addition, the sesquiterpene lactone compound can be prepared by fermentation, separation and purification of marine microorganisms of the fungus genus Arenariomyces, and the preparation method is simple, the source is rich, and the industrial production preparation is facilitated.

The present invention relates to the use of eudesmanolides sesquiterpene lactones as a biostimulant of fungal spore germination and / or of plant mycorrhization. More specifically, it relates to the use of eudesmanolides sesquiterpene lactones to stimulate spore germination and hyphae development in arbuscular mycorrhizal fungi and / or to increase mycorrhization capacity in plants.

The application discloses a ginger-wilt disease comprehensive prevention and control method and a matching planting system of ginger-Asteraceae crop interplanting and biocontrol bacteria cooperation. The ginger-wilt disease comprehensive prevention and control method adopts a four-time-point process of "pre-sowing Asteraceae plants, ginger transplanting at the same period, root dipping (ginger seed soaking) / hole applying biocontrol bacteria, timing cutting for in-situ biological fumigation before flood season, and drip irrigation for bacteria supplementing", constructs a rhizosphere symbiosis-disease inhibition zone, utilizes the root secretion and volatile substances (such as thiothiophene, sesquiterpene lactone, etc.) of Asteraceae plants and the straw cutting and returning biological fumigation effect, cooperates with Bacillus-Trichoderma-Pseudomonas / Streptomyces compound bacterial agent, and significantly inhibits the colonization and migration of Ralstonia solanacearum. Compared with conventional monoculture, the application can reduce the disease index by 40-70%, increase the yield of commercial ginger by 10-22%, and reduce the use intensity of chemical pesticides. The application is compatible with existing drip irrigation, mulching and high-ridge cultivation, and is suitable for large-area application in the Sichuan-Chongqing high-humidity continuous cropping ecological niche.

The present application relates to the technical field of pharmaceutical chemistry, and discloses a kind of guaiane type sesquiterpene lactone compound, wild chrysanthemum extract and its preparation method and application.The guaiane type sesquiterpene lactone compound has the structure shown in formula (I).Research shows that the guaiane type sesquiterpene lactone compound with the structure shown in formula (I) and wild chrysanthemum extract have obvious inhibitory effect on NF-κB nuclear translocation.Therefore, further using the guaiane type sesquiterpene lactone compound with the structure shown in formula (I) or wild chrysanthemum extract as effective component for preparing anti-inflammatory drugs and treating inflammatory diseases caused by NF-κB nuclear translocation has important application value.

The present invention relates to methods of minimizing the effects of non-targeted and / or non-therapeutic radiation exposure in an individual. In one aspect, the present invention provides a method of minimizing the effects of non-targeted and / or non-therapeutic radiation exposure in an individual, the method comprising administering a sesquiterpene lactone to the individual, thereby minimizing the effects of non-targeted and / or non-therapeutic radiation exposure in the individual.