Compound coating coronary medicament eluting stent and preparation method thereof

Abstract

The invention discloses a compound coating coronary medicament eluting stent and a preparation method thereof. The compound coating coronary medicament eluting stent comprises a supporting naked stent, a phosphorylcholine polymer coating and a degradable medicament carrying polymer coating, wherein the phosphorylcholine polymer coating is coated on the surface of the naked stent; and the degradable medicament carrying polymer coating is coated on the surface of the phosphorylcholine polymer coating. The stent is transplanted at a lesion position in the bodies of the coronary disease patients, the outer degradable medicament carrying polymer coating gradually degrades and releases the loaded medicament to restrain the blood restenosis caused by smooth muscle proliferation in the blood vessels, after the outer medicament carrying coating degrades completely, the stent of the phosphorylcholine polymer coating is left, the pseudo membrane characteristics of the phosphorylcholine radical makes the metal stent more biocompatible, so cell coverslips are increased, the poststage coalescence of the stent and the blood vessel is promoted, stent endothelialisation is promoted, and better curative effects and long-term safety are provided.

Description

A composite coated coronary drug-eluting stent and a preparation method thereof technical field The invention relates to a device in the field of medical devices and a preparation method thereof, in particular to a composite-coated coronary drug-eluting stent and a preparation method thereof. Background technique Coronary atherosclerotic heart disease (referred to as coronary heart disease, CHD) is a heart disease caused by atherosclerotic lesions in the coronary arteries resulting in narrowing or blockage of the coronary arteries. It is a relatively common type of cardiovascular and cerebrovascular diseases. The average incidence rate is about 6%, and more than 1 million people die from coronary heart disease every year, while the World Health Organization predicts that the "epidemic peak" of coronary heart disease will continue until about 2020. Currently, the most effective treatments for coronary heart disease are Percutaneous Coronary Intervention (PCI) and Coronary A...

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Problems solved by technology

However, the degradable drug-containing polymer leaves only the metal stent after degradation, and the drug greatly inhibits the proliferation of the intracellular membrane during the degradation and release of the polymer, which reduces the problem of restenosis after stent implantation and also leads to cell crawling. The reduction of the skin makes it difficult for the stent to heal well with the vessel wall

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