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O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base bacteriostatic agent and preparation method thereof

A technology of polychitosan water and oligochitosan, which is applied in the field of natural antibacterial agent-O-salicylated chitosan salicylaldehyde Schiff base and its preparation, can solve the problem of no inhibitory activity and antibacterial activity Low-level problems, to achieve the effect of improved antibacterial performance, simple operation, and safe operating environment

Inactive Publication Date: 2012-01-18
BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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  • Abstract
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Problems solved by technology

However, compared with the existing chemically synthesized antibacterial agents, the antibacterial activity is still low and basically has no inhibitory activity against fungi

Method used

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  • O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base bacteriostatic agent and preparation method thereof
  • O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base bacteriostatic agent and preparation method thereof
  • O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base bacteriostatic agent and preparation method thereof

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Experimental program
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Embodiment

[0027] Dissolve 2.0 g of chitosan oligosaccharides with a relative molecular weight of 5000 in 60 ml of 2% by volume acetic acid solution, place in a three-necked flask equipped with a stirrer; add 60 ml of methanol, mix well and then swell for 1 h. Add the aldehyde (-CHO / -NH) dissolved in 60ml methanol to the reaction system 2 The molar ratio was 8:1), and the reaction was stirred at room temperature for 24h.

[0028] Take out the reaction solution, add dropwise 10wt% NaOH solution to adjust the pH value to be neutral, wash with 180ml acetone each time, filter 3 times; then use 180ml 5wt% NaHCO 3 The solution was soaked and stirred at room temperature for 100 minutes, filtered, and then washed with deionized water repeatedly until neutral. Finally soaked in methanol overnight, filtered and vacuum-dried at 40° C. to constant weight to obtain the oligomeric chitosan salicylaldehyde Schiff base, whose Schiff base substitution degree was 100 mol% by elemental analysis.

[0029]...

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Abstract

The invention discloses a natural bacteriostatic agent of O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base and a preparation method thereof. The preparation method comprises the following steps: firstly modifying C2-NH2 on a molecular structure of oligo-chitosan with strong bacteriostasis by salicylaldehyde so as to synthesize oligo-chitosan salicylaldehyde Schiff base; then performing condensation of C6-OH on the oligo-chitosan salicylaldehyde Schiff base by a DDC method to form O-salicylic acid esterified oligo-chitosan salicylaldehyde Schiff base. The preparation method has simple operations, and safe operation environment, and the obtained oligo-chitosan derivative has significantly improved antibacterial properties. The O-salicylic acid esterified oligo-chitosansalicylaldehyde Schiff base of the invention can be used as a bacteriostatic agent which has inhibition effect on escherichia coli, aureus staphylococcus, and saccharomyces cerevisiae.

Description

technical field [0001] The invention belongs to a natural antibacterial agent-O-salicylate oligomeric chitosan salicylaldehyde Schiff base and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the concepts of health and green are more and more accepted by the public. The development of highly efficient, safe, broad-spectrum, and stable natural antiseptic antibacterial agents has attracted more and more attention from researchers. The market demand for natural antiseptic and antimicrobial agents is also bound to grow day by day. [0003] Research results at home and abroad show that the antibacterial activity of chitosan has a certain correlation with the molecular weight, and the oligomeric chitosan with a molecular weight below 5000 shows a strong antibacterial activity. However, compared with the existing chemically synthesized antibacterial agents, the antibacterial activity is still low and basically has no i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A01N43/16A01P1/00A01P3/00
Inventor 林强韩永萍覃菲
Owner BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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