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Sticky Soft Gel For Treating Poultry

A sticky, soft technology for applications, ointment delivery, veterinary vaccines, etc.

Active Publication Date: 2012-05-30
SEVA ANIMAL HEALTH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the sensitivity of virus vaccines to chlorine and other disinfectants commonly used in poultry houses, water lines must be cleaned or flushed prior to vaccine administration

Method used

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  • Sticky Soft Gel For Treating Poultry
  • Sticky Soft Gel For Treating Poultry
  • Sticky Soft Gel For Treating Poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Experiments were carried out to determine the appropriate amount of gelling agent to use in the gel form. For a mixture of maltodextrin, carrageenan, and carboxymethyl cellulose supplemented with xanthan gum (60 / 40 dilution of Vetech Laboratories Inc. and water dilution of Vetech Laboratories Inc. as described herein), the test their ability to produce suitable gels. The dry components are mixed with water at a final ratio of 0.7 to 1.5% w / v and the gel thus formed is distributed on the plastic surface to form small microcapsules. The plastic surface was then twisted at an angle to determine the viscosity of the gel droplets. From this test, it was determined that all of these mixtures could be used. For example, a suitable formulation is a dry mixture of about 25% maltodextrin, 67% carrageenan, 4% carboxymethyl cellulose with the addition of 4% xanthan gum, and this mixture is used in further experiments. All percentages are by weight.

[0043] The same experiment ...

Embodiment 2

[0045] Infectious Bursal Disease (IBD) Gel Spray Immunization

[0046] Twenty-five SPF chickens were used in this trial to determine whether the gel spray delivery system could be used to deliver vaccine or biological material to commercial chickens and turkeys outside the hatchery. Blood samples (~0.5 ml) were collected from the jugular veins of 10 randomly selected chickens one day before immunization or at 6 days of age. At 7 days of age, 25 birds were divided into three groups and immunized as follows:

[0047] Group 1 - Water immunization by gavage (6 birds)

[0048] Group 2 - Gel Diluent (6 birds) by gavage

[0049] Group 3 - Gel Diluent by Hand Spray (13 birds)

[0050] Vaccine preparation for groups 1, 2 and 3:

[0051] The vaccine stabilizer was prepared by suspending 0.7 gm of nonfat dry milk in 250 ml of distilled water. To this 250 ml stabilizer was added two thirds of a bottle of 2,500 doses of IBDV (strain s-706) to make a total of 1,000 doses. To this s...

Embodiment 3

[0063] Infectious Bursal Disease (IBD) Gel Spray Vaccination

[0064] The above example was repeated using 25 birds divided into 5 groups as follows:

[0065] Group 1 - No treatment

[0066] Group 2 - Water, Tube Feeding

[0067] Group 3 - Gel, by gavage

[0068] Group 4 - Gel + Immucox, by gavage

[0069] Group 5 - Gel Spray

[0070] Groups 3, 4 and 5 gels contained 0.1% w / v xanthan gum and Vetech Laboratories Inc.'s 60 / 40 gel diluent. Group 2 treatments contained no xanthan gum or diluent, only water. Group 1 was the control group and received no treatment.

[0071] Blood samples (~0.5 ml) were collected from the jugular vein on the appropriate days after immunization, and ELISA testing of all blood samples to check for the presence or absence of IBD was performed by Laboratory Services, Laboratory of Animal Health, University of Guelph of the Animal Health Laboratory of the University of Guelph, Guelph, Ontario).

[0072] Results overview:

[0073] Table 2

[...

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Abstract

The present invention is directed to a composition, kit and method for delivering a soft flowable gel to a flock of poultry in barns, but can also be used in hatcheries or free range farms, for treating poultry with a therapeutic agent. The soft flowable gel comprises water, a gelling agent, a therapeutic agent and between about 0.05% and 0.15% xanthan gum.

Description

Field of Invention [0001] The present invention relates to a viscous soft gel for the treatment of poultry flocks, especially poultry in poultry houses and poultry in hatcheries or free-range farms. In particular, the present invention relates to viscous soft gels for the delivery of therapeutic agents, particularly viral, bacterial or protozoan vaccines, to flocks of poultry in poultry houses. Background of the Invention [0002] In many cases, poultry must be treated, for example, by administering a therapeutic agent. There are many therapeutic agents available for poultry farming: vaccines, products of competitive exclusion, vitamins, minerals, drugs and many others. A large number of such therapeutic agents must be protected from environmental influences when delivered to poultry. [0003] Specifically, poultry needs to be immunized against a variety of diseases, and the type of vaccine used for each disease determines how it is administered. In hatcheries, vaccines c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A23K1/18A61K39/00A61P37/04A61P9/10A61P9/14A23K50/75A23L29/20
CPCC12N2760/18134A61K39/0275A23K1/1643A61K39/12A23K1/1826A61K39/17A61K9/06A23K1/002A23L1/05A61K9/0095A61K9/7015A61K47/36A61K2039/522A61K2039/552C12N2720/10034A23K40/10A23K20/163A23K50/75A23L29/20A61P31/04A61P31/12A61P31/14A61P31/20A61P31/22A61P33/02A61P37/04A61P9/10A61P9/14Y02A50/30
Inventor 恩格-宏·李
Owner SEVA ANIMAL HEALTH LTD
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