Application of radioisotope-marked sunshine anthrone compound in preparing anti-tumor medicine

A technology of radioisotopes and anti-tumor drugs, applied in the directions of anti-tumor drugs, radioactive carriers, drug combinations, etc., can solve the problem of no research and report on intratumor radiation therapy

Inactive Publication Date: 2013-10-02
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no studies and reports on radioactive isotope-labeled products of the above compounds as tumor internal radiation therapy

Method used

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  • Application of radioisotope-marked sunshine anthrone compound in preparing anti-tumor medicine
  • Application of radioisotope-marked sunshine anthrone compound in preparing anti-tumor medicine
  • Application of radioisotope-marked sunshine anthrone compound in preparing anti-tumor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 131 I label prohypericin to treat H 22 Study on the Effect of Tumor Mice

[0026] Materials and Methods:

[0027] Kunming male mice; original hypericin was purchased from Shaanxi Jintai Biological Engineering Co., Ltd.

[0028] Subcutaneously plant solid tumor mice, inject 0.1mL of peritoneal fluid containing mouse H22 tumor cells into the subcutaneous area of ​​the axilla of the planted mice, and tumor masses form after 5 days. Twenty-four tumor-bearing mice between 1.5 cm and 1.5 cm were used in the experiment, and were randomly divided into 4 groups according to the tumor size, 6 mice per group. The blank group was not treated, and the other three treatment groups were intravenously injected with 1, 2, 5mCi / Kg radioactive drugs respectively.

[0029] Observation of curative effect Injected separately according to the predetermined plan 131 I mark the original hypericin, measure the long and short diameter of the tumor with a vernier caliper every day before sta...

Embodiment 2

[0035] 131 I label protohypericin to treat H 22 Study on the Effect of Tumor Mice

[0036] Materials and Methods:

[0037] Kunming male mice; original pseudohypericin was purchased from Shaanxi Jintai Biological Engineering Co., Ltd.

[0038] Subcutaneously plant solid tumor mice, inject 0.1mL of peritoneal fluid containing mouse H22 tumor cells into the subcutaneous area of ​​the axilla of the planted mice, and tumor masses form after 5 days. Twenty-four tumor-bearing mice between 1.5 cm and 1.5 cm were used in the experiment, and were randomly divided into 4 groups according to the tumor size, 6 mice per group. The blank group was not treated, and the other three treatment groups were intravenously injected with 1, 2, 5mCi / Kg radioactive drugs respectively.

[0039] Observation of curative effect Injected separately according to the predetermined plan 131 I mark the original pseudo-hypericin, measure the long and short diameter of the tumor with a vernier caliper every...

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PUM

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Abstract

The invention relates to a radioisotope-marked sunshine anthrone compound comprising chemical elements or isotopes with unstable nuclei. Radiation is emitted during a decaying or stable state forming period of the compound. The radiation is capable of damaging adjacent cells or tissues. Therefore, the compound can be used in targeted radiotherapy, such that the curability of warm-blooded animals in anti-tumor treatments can be improved. A special advantage of the compound provided by the invention is that: single-time or multi-time dosage treatments by using the radioisotope-marked sunshine anthrone compound can be carried out for treating advanced-stage tumors.

Description

field of invention [0001] The present invention relates to radioisotopically labeled napthodianthrone compounds comprising chemical elements or isotopes with unstable nuclei which, during their decay to a stable state, emit radiation sufficient to destroy adjacent cells Or tissue for targeted radiation therapy to treat tumors in warm-blooded animals. A particular advantage of the present invention is that living margins or tumor remnants resistant to tumor therapy can be further processed. This treatment is administered by intravenous injection of single or multiple doses of radioisotope-labeled small molecules, including sun-irradiated anthrone compounds, that selectively accumulate in established intratumoral areas to emit radiation, thereby achieving therapeutic or Inhibition of tumor growth effects. Background of the invention [0002] Malignant tumors are still a serious threat to human health. Except for early detection and surgical resection, there is no definite cu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/04A61P35/00A61K101/02A61K103/00A61K103/10A61K103/30A61K103/32A61K103/34
Inventor 张健倪以成孙自平黄德健孔铭朱佳蒋翠花姚楠
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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