A multiple modality imaging system (10) includes a MR scanner (12) which defines an MR imaging region (18), a nuclear imaging scanner (26) which defines a nuclear imaging region (34), an CT scanner (36) which defines an CT imaging region (42). Each scanner (12, 26, 36) having a longitudinal axis along which a common patient support (46) moves linearly through the MR, nuclear, and CT imaging regions (18, 34, 42). A marker (130, 140, 150), for use with the system (10), includes a radio-isotope marker (132) which is imageable by the nuclear imaging scanner (26) and the CT scanner (36) surrounded by a flexible silicone MR marker (134) which is imageable by the MR scanner (12) and the CT scanner (36). A calibration phantom(162), for use with the image scanner (10), includes a plurality of the markers (130, 140, 150) supported by a common frame having a known and predictable geometry.