Radioisotope labeled meso-porous bioglass porous scaffold and making method thereof

Abstract

The invention provides a radioisotope labeled meso-porous bioglass porous scaffold. A meso-porous bioglass porous scaffold is labeled with radioisotope, and the radioisotope can be one or more of <31>Si, <32>P and <45>Ca. The radioisotope labeled meso-porous bioglass porous scaffold can effectively label the meso-porous bioglass porous scaffold, can quantitatively and intuitively detect the in vivo degradation situation of the meso-porous bioglass porous scaffold, and can be used to research the in vivo absorption and the organism distribution of the bioglass scaffold.

Description

technical field [0001] The invention relates to a mesoporous biological glass porous support, in particular to a radioactive isotope-labeled mesoporous biological glass porous support. Background technique [0002] Bioglass can achieve specific biological and physiological functions, and has good biocompatibility, biodegradability and mechanical properties. In 1971, Hench et al. first prepared bioactive glass (BG) materials with bone repair properties by melting method. After more than 30 years of research and development, bioglass has been applied to bone tissue replacement, bone defect repair, and bone filling materials. and biological coatings. [0003] However, studies have found that dense bioglass has problems such as slow degradation rate, insufficient biological activity, and unfavorable osteogenesis. Therefore, people try to improve the bioactivity and degradation performance of bioglass by designing porous scaffolds and introducing mesoporous structure into biogl...

AI Technical Summary

Problems solved by technology

[0004] However, a series of issues about the degradation characteristics, metabolic fate, and effects on local and systemic tissues and organs of mesoporous bioglass scaffolds in vivo are still unclear.

To answer these questions, it is first necessary to solve the degradation of the scaffold entering the organism and the tracking of degradation products. The premise of the tracking is to determine whether the mesoporous bioglass porous scaffold can be effectively labeled? Is the marker appropriate for the degradation time of the stent? How stable is the marker itself? Wait, so far, there is no effective method for labeling porous scaffolds of mesoporous bioglass

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