Radioisotope labeled meso-porous bioglass porous scaffold and making method thereof

A radioactive isotope and bioglass technology, applied in medical science, prostheses, etc., can solve the problems of the degradation characteristics of mesoporous bioglass porous scaffolds and the unclear influence of metabolic outcome

Inactive Publication Date: 2014-10-29
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0004] However, a series of issues about the degradation characteristics, metabolic fate, and effects on local and systemic tissues and organs of mesoporous bioglass scaffolds in vivo are still unclear.
To answer these questions, it is first necessary to solve the degradation of the scaffold entering the organism and the tracking of...

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  • Radioisotope labeled meso-porous bioglass porous scaffold and making method thereof
  • Radioisotope labeled meso-porous bioglass porous scaffold and making method thereof
  • Radioisotope labeled meso-porous bioglass porous scaffold and making method thereof

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[0062] Radionuclide labeling and tracing technology uses radionuclide or its labeled compound as a tracer, uses radiation to detect the distribution of the tracer, and combines autoradiography, microscope observation and counting, liquid scintillation counter, etc. for qualitative and quantitative The method of observation and analysis has the characteristics of high sensitivity, simple method, and accurate positioning and quantification. Therefore, the use of radionuclide labeling and tracing technology to label mesoporous bioglass porous scaffolds can provide information for the biodistribution and fate of scaffold materials in vivo. Research provides important technical means.

[0063] Mesoporous bioglass porous scaffold based on CaO-SiO 2 -P 2 o 5 As the basic composition, in vitro studies have proved that a large amount of Ca, Si and P elements can be detected after the scaffold is soaked in simulated body fluid for different periods of time, which indicates that the de...

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Abstract

The invention provides a radioisotope labeled meso-porous bioglass porous scaffold. A meso-porous bioglass porous scaffold is labeled with radioisotope, and the radioisotope can be one or more of <31>Si, <32>P and <45>Ca. The radioisotope labeled meso-porous bioglass porous scaffold can effectively label the meso-porous bioglass porous scaffold, can quantitatively and intuitively detect the in vivo degradation situation of the meso-porous bioglass porous scaffold, and can be used to research the in vivo absorption and the organism distribution of the bioglass scaffold.

Description

technical field [0001] The invention relates to a mesoporous biological glass porous support, in particular to a radioactive isotope-labeled mesoporous biological glass porous support. Background technique [0002] Bioglass can achieve specific biological and physiological functions, and has good biocompatibility, biodegradability and mechanical properties. In 1971, Hench et al. first prepared bioactive glass (BG) materials with bone repair properties by melting method. After more than 30 years of research and development, bioglass has been applied to bone tissue replacement, bone defect repair, and bone filling materials. and biological coatings. [0003] However, studies have found that dense bioglass has problems such as slow degradation rate, insufficient biological activity, and unfavorable osteogenesis. Therefore, people try to improve the bioactivity and degradation performance of bioglass by designing porous scaffolds and introducing mesoporous structure into biogl...

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Application Information

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IPC IPC(8): A61L27/10A61L27/50A61L27/56C03C11/00
Inventor 孙皎隋佰延钟高仁
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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