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Novel method for establishing vascular dementia rat model

A vascular dementia and rat model technology, applied in medical science, veterinary equipment, animal husbandry, etc., can solve problems such as emotional disorders, cognitive and language function decline, and memory impairment

Inactive Publication Date: 2012-06-27
XINXIANG MEDICAL UNIV
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  • Description
  • Claims
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Problems solved by technology

[0006] Some social survey data show that long-term, low-dose exposure to organophosphorus pesticides can lead to memory impairment, cognitive and language function decline, emotional disorders and other symptoms

Method used

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  • Novel method for establishing vascular dementia rat model
  • Novel method for establishing vascular dementia rat model
  • Novel method for establishing vascular dementia rat model

Examples

Experimental program
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Effect test

experiment example

[0023] Experimental example: To test the feasibility of establishing VD model by intragastric administration of isocarbophos.

[0024] 1. Drug: isocarbophos (LS93564, 20%, Hubei Sanonda Co., Ltd.).

[0025] 2. Objective: To establish VD model by intragastric administration of isocarbophos to SD rats for 24 weeks.

[0026] 3. Instruments: Rat jumping platform recording system, rat dark avoidance instrument, Morris water maze (Huaibei Zhenghua Biological Instrument Equipment Co., Ltd.); MD3000 biological signal acquisition system (Huaibei Zhenghua Biological Instrument Equipment Co., Ltd.); TS1000 Nikon microscope ( Nikon Corporation of Japan); HT7700 Hitachi Transmission Electronic Display (Hitachi Corporation of Japan).

[0027] 4. Animals: 6 weeks old, male, 180-220g, clean grade, healthy SD rats (Henan Province Experimental Animal Center).

[0028] 5. Experimental grouping: ① Normal control group: 6 weeks old, male, 180~220g, clean grade, 10 healthy SD rats, fed for 24 w...

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Abstract

The invention discloses a novel method for establishing a vascular dementia rat model. According to the novel method, a 6-week old male clean and healthy Sprague Dawley (SD) rat with the weight of 180-220g is subjected to long-term gavage by adopting isocarbophos, wherein the gavage concentration of the isocarbophos is 0.5mg / kg, the gavage capacity is 3ml / kg, the gavage frequency is one time every other day, and the gavage period is 24 weeks. The vascular dementia rat model is established through chronic damage of the isocarbophos to the brain vessels and brain nervous tissues of the SD rat.

Description

technical field [0001] The present invention relates to a novel method for establishing a rat model of vascular dementia, specifically a long-term gavage of SD rats with isocarbophos, and treatment of blood vessels and brain nerve tissues of SD rats with isocarbophos Cause chronic injury to establish a rat model of vascular dementia. Background technique [0002] VD (Vascular Dementia, VD) is a dementia syndrome caused by brain tissue damage caused by a series of vascular damage factors. A group of dementia syndromes mainly characterized by memory impairment and cognitive function decline, or accompanied by language function decline, emotion and personality disorders as the main clinical manifestations. [0003] In European and American countries, VD accounts for 15% of the total number of senile dementias; in China, Japan and other Asian countries, VD accounts for 50% of the total number of senile dementias. At present, the prevalence of VD in my country is 324 / 100,000, a...

Claims

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Application Information

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IPC IPC(8): A61D7/00A01K67/027
Inventor 尹雅玲侯软玲毕凌云王建刚王亚莉朱利红张群妹张洁袁向山潘国聘王倩倩王永霞马丽娟杨帆陈杰李鹏
Owner XINXIANG MEDICAL UNIV
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