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Pantoprazole sodium medicinal composition and preparation method thereof

A technology of pantoprazole sodium and its composition, which is applied in the field of pantoprazole sodium pharmaceutical composition and its preparation, can solve the problems of high safety risk, high content, instability of related substances, and easy discoloration of the solution, so as to improve safety low hygroscopicity and good stability

Active Publication Date: 2012-07-04
湖北美林药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new medicine called PANOPHOS® contains certain chemicals that help make it last longer without losing its effectiveness or causing harmful side-effects like gastrointestinal disorders when given through this route (oral).

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the stability or coloring property (pironopeptide drug) properties of pantothiazolone sodium compositions that can withstand long storage at room temperature without losing their effectiveness due to changes caused during manufacturing processes.

Method used

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  • Pantoprazole sodium medicinal composition and preparation method thereof
  • Pantoprazole sodium medicinal composition and preparation method thereof
  • Pantoprazole sodium medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Pantoprazole sodium: 40g (calculated as pantoprazole)

[0066] Mannitol: 160g

[0067] Polysorbate 80: 150g

[0068] 2-Hydroxypropyl-β-cyclodextrin: 300g

[0069] Water for injection: 2000ml

[0070] Prepare 1000 sticks

Embodiment 2

[0072] Pantoprazole sodium: 40g (calculated as pantoprazole)

[0073] Mannitol: 160g

[0074] Polysorbate 80: 120g

[0075] 2-Hydroxypropyl-β-cyclodextrin: 200g

[0076] Water for injection: 2000ml

[0077] Prepare 1000 sticks

Embodiment 3

[0079] Pantoprazole sodium: 40g (calculated as pantoprazole)

[0080] Mannitol: 160g

[0081]Polysorbate 80: 250g

[0082] 2-Hydroxypropyl-β-cyclodextrin: 400g

[0083] Water for injection: 2000ml

[0084] Prepare 1000 sticks

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PUM

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Abstract

The invention relates to a pantoprazole sodium medicinal composition which is prepared by dissolving 40g of pantoprazole sodium, 160g of mannitol, 120-300g of polysorbate and 200-600g of 2-hydroxypropyl-beta-cyclodextrin in 2,000ml of injection water and then freeze-drying. The pantoprazole sodium medicinal composition provided by the invention has the advantages of good stability and low hygroscopicity; and after prepared into injection, the pantoprazole sodium medicinal composition has the advantages that the relatively long-time stability can be maintained, and the medicine safety is improved.

Description

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Claims

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Application Information

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Owner 湖北美林药业有限公司
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