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Injecta containing milrinone and preparation method thereof

A technology of injection and milrinone, applied in the field of injection containing milrinone and its preparation, to achieve good liver and kidney protection function, prolong survival time, and improve the effect of hemorrhagic shock symptoms

Active Publication Date: 2013-11-06
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, milrinone can improve the hemodynamics, systemic oxygen supply, and oxygen consumption of shock patients, especially for cardiogenic shock induced by acute myocardial infarction, but it is powerless for patients with severe shock symptoms

Method used

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  • Injecta containing milrinone and preparation method thereof
  • Injecta containing milrinone and preparation method thereof
  • Injecta containing milrinone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 milrinone injection

[0017] Prescription composition:

[0018]

[0019] Preparation Process:

[0020] (1) Weigh 5g of amiodarone hydrochloride, add it to 250ml of ethanol, stir until dissolved, and set aside;

[0021] (2) Weigh 5g of milrinone, add it to 3L of water for injection, stir, adjust the pH value of the solution to 4.0 with hydrochloric acid solution, continue to stir until it is completely dissolved, add 45 grams of sodium chloride, stir to completely dissolve, add step (1 ), add water for injection to 5L, mix well, filter with 0.45μm microporous membrane, fill 1000 bottles, and sterilize.

Embodiment 2

[0022] The preparation of embodiment 2 milrinone injection

[0023] Prescription composition:

[0024]

[0025] Preparation Process:

[0026] (1) Weigh 10 g of amiodarone hydrochloride, add in 400 ml of ethanol, stir until dissolved, and set aside;

[0027] (2) Weigh 5g of milrinone, add it to 3L of water for injection, stir, adjust the pH value of the solution to 4.0 with lactic acid solution, continue to stir until it is completely dissolved, add 40 grams of sodium chloride, stir to completely dissolve, add step (1 ) prepared solution, add water for injection to 5L, mix evenly, filter with 0.45 μm microporous membrane, fill 1000 bottles, and sterilize.

Embodiment 3

[0028] The preparation of embodiment 3 milrinone injection

[0029] Prescription composition:

[0030]

[0031] Preparation Process:

[0032] (1) Take by weighing 2.5g of amiodarone hydrochloride, add in 200ml ethanol, stir until dissolving, set aside;

[0033] (2) Weigh 5g of milrinone, add it to 3L of water for injection, stir, adjust the pH value of the solution to 4.0 with lactic acid solution, continue to stir until it is completely dissolved, add 45 grams of sodium chloride, stir to completely dissolve, add step (1 ) prepared solution, add water for injection to 5L, mix evenly, filter with 0.45Pm microporous membrane, fill 1000 bottles, and sterilize.

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PUM

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Abstract

The invention discloses injecta containing milrinone and a preparation method of the injecta. The injecta contains the components of 1g / L of milrinone, 0.5-2g / L of amiodarone hydrochloride, 0.8-1.0% (w / v) of sodium chloride and 4-10% (v / v) of ethanol. The dosage of a pharmaceutically acceptable acidic material is that pH of the injecta is 3.0-5.0, and the balance is injection water. According to the injecta disclosed by the invention, the symptoms of hemorrhagic shock can be effectively improved; generation of anaerobic respiration lactic acid is restrained under an anaerobic condition; the injecta has a good function on protecting liver and kidney, and the survival time of a sufferer is obviously prolonged.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, and in particular relates to an injection containing milrinone and a preparation method thereof. Background technique [0002] Milirinone is the general name of 1,6-dihydro-2-methyl-6-oxo-[3,4`-bispyridine]-5-carbonitrile, which is non-digitalis and non-catecholamine strong Heart medicine, an alternative to Amrinone. Experiments have shown that milrinone can increase myocardial contractility by selectively inhibiting phosphodiesterase III in cardiomyocytes, increasing intracellular cyclic adenosine monophosphate (C-AMP), and changing the transport of intracellular and extracellular calcium. Milrinone has a direct relaxing effect on vascular smooth muscle, which can reduce the preload and afterload of the heart. Milrinone can significantly reduce systemic vascular resistance, pulmonary vascular resistance, mean pulmonary arterial pressure and pulmonary capillary wedge press...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/444A61K47/22A61P9/04A61P7/08
Inventor 王宽起梁波
Owner NANJING CHIA TAI TIANQING PHARMA
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