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New method for treating helicobacter pylori related diseases

A technology for Helicobacter pylori and diseases, applied in Polygonaceae plants and its extracts for the treatment of Helicobacter pylori-related diseases, in the field of treating Helicobacter pylori-related diseases, Chinese herbal medicine Polygonum cephalum or its extracts, which can solve serious, antibiotic-related diseases drug resistance issues

Active Publication Date: 2012-12-19
ZHEJIANG ZHONGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hp anti-infection treatment is mainly triple or quadruple therapy based on antibiotics, but as multiple antibiotics are widely used in anti-Hp treatment, Hp resistance to antibiotics is becoming more and more serious, which has become the main reason for the failure of eradication therapy

Method used

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  • New method for treating helicobacter pylori related diseases
  • New method for treating helicobacter pylori related diseases
  • New method for treating helicobacter pylori related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: Preparation of the aerial part water extract of Polygonum cephalum

[0061] Take 220kg of the aerial part (dry product) of Polygonum cephalum, wash it, add 7 times the amount of water, heat and boil for 1.5 hours, filter, add 6 times the amount of water to the dregs, boil for 1.0 hour, and filter. Merge filtrate, be concentrated to relative density and be 1.2 (20 ℃) ​​obtain extractum, spray dry and obtain extract powder 23.1kg (yield 10.4%), be the Polygonum cephalum extract of the present embodiment: brown powder; Every g sample is equivalent to Yu crude drug 8.7g; measured by spectrophotometer, flavonoid content: 18.21mg / g, gallic acid content: 17.82mg / g.

[0062] Take 1 part of the above extract powder, add 2 parts of starch and 2 parts of microcrystalline cellulose, mix evenly, and pack into capsules, which is the pharmaceutical composition of the present invention.

Embodiment 2

[0063] Embodiment 2: Preparation of the whole herb water extract of Polygonum cephalum (spray drying)

[0064] Referring to the method of Example 1, the difference is that the whole plant of Polygonum cephalosporin (fresh product) is used to replace the above-ground part of Polygonum cephalosporin for extraction to obtain the Polygonum cephalosporin extract of this embodiment. Yield 8.12%.

Embodiment 3

[0065] Embodiment 3: Preparation of 95% ethanol extract of Polygonum cephalum root

[0066] Take 10 kg of dried roots of Polygonum cephalum, wash them, put them in a stainless steel concentration tank, add 7.5 times the amount of 95% ethanol, reflux extraction for 1.5 hours, and filter. Add 7.5 times the amount of 95% ethanol to the dregs, extract under reflux for 1.0 hour, and filter. The two filtrates were combined, concentrated to obtain extract, and dried under reduced pressure to obtain the extract of this example, 0.34 kg.

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Abstract

The invention relates to a new method for treating helicobacter pylori related diseases, in particular to application of polygonum capitatum or extract thereof in preparing a medicine for treating and / or preventing the diseases or symptoms related to helicobacter pylori infection. The invention discovers that the extract can effectively suppress the helicobacter pylori.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine, in particular, the present invention relates to a new method for treating diseases related to Helicobacter pylori, in particular to a new method for treating diseases related to Helicobacter pylori with a Polygonaceae plant and its extract, especially Chinese herbal medicine head A new method for the treatment of Helicobacter pylori-related diseases by Polygonum florum or its extract. Background technique [0002] Polygonum capitatum (Polygonum capitatum Buch.-Ham.ex D.Don) is a plant of the genus Polygonum, which is a perennial herb. Dihong and so on. It is distributed in Guizhou, Yunnan, Guangxi, Sichuan, Tibet, Hubei, Hunan and Jiangxi in China, and mainly grows in hillsides, valleys and sandy shale areas rich in coal seams. The whole plant has the effects of clearing heat and detoxifying, dispelling blood stasis, diuresis and treating stranguria. According to the second ...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P1/04A61P7/00A61P7/06A61P9/10A61P9/12A61P31/04A61P35/00
Inventor 王子厚莫非张淑华张姝胡伏莲杨国珍罗昭逊夏曙华孙朝琴张然
Owner ZHEJIANG ZHONGKANG PHARMA CO LTD
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