Method for extracting four different effective components in Radix Scutellariae with subcritical water

An active ingredient, subcritical water technology, applied in chemical instruments and methods, organic chemistry, preparation of sugar derivatives, etc., can solve problems such as residues, adverse effects on the human body, etc., to achieve less use, smooth extraction process, and high purity. Effect

Inactive Publication Date: 2014-08-06
SHANDONG ANALYSIS & TEST CENT
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Problems solved by technology

Although this method has many advantages, its biggest disadvantage is that there are residues of organic solvents in the extract, which will have adverse effects on the human body. Therefore, in recent years, subcritical water has been used in industry to extract the active ingredients in Scutellaria baicalensis It is one of the important subjects that those skilled in the art have been studying

Method used

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Embodiment Construction

[0021] A method for extracting four different active ingredients in Scutellaria baicalensis with subcritical water of the present invention comprises the following steps:

[0022] ① Grind Scutellaria baicalensis into 80-100 mesh particles for later use;

[0023] ②Take Scutellaria baicalensis granules and water, put them into the extraction kettle at a ratio of 1:25-27 by weight, close the extraction kettle and place it in a heating controller preheated to a temperature of 80°C-100°C, the temperature of the material in the extraction kettle Control at 110°C-130°C, the pressure of the extraction tank is 0.3-0.6MPa, the material temperature is kept at 110°C-130°C for 8-10 minutes, and then cooled to room temperature within 3-5 minutes, and the liquid residue is separated to obtain The liquid of baicalein and wogonin;

[0024] ③Add water to the filter residue in step ② according to the weight ratio of Scutellaria baicalensis and water: 1:20-23, close the extraction kettle, the pr...

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Abstract

The invention provides a method for extracting four different effective components in Radix Scutellariae with subcritical water, wherein the method comprises the following steps: (1) crushing the Radix Scutellariae into particles for use; (2) taking the Radix Scutellariae particles and water to place into an extraction kettle, after sealing the extraction kettle, placing the extraction kettle into a temperature heating controlling instrument, cooling materials in the extraction kettle to a room temperature for 3 -5 minutes, separating liquid from the slag to obtain a scutellarin and wogonin containing liquid; (3) adding water into the filter slag in the step (2), sealing the extraction kettle, heating the materials in the extraction kettle, after keeping the temperature for 28 -32 minutes, cooling the extraction kettle to the room temperature, separating liquid from slag to remove the slag to obtain a baicalin and wogonoside containing liquid; and (4) vaporizing water from the scutellarin and wogonin containing liquid obtained in the step (2) and the baicalin and wogonoside containing liquid obtained in the step (3) respectively to obtain the powder of four Radix Scutellariae effective components of scutellarin, wogonin, baicalin and wogonoside respectively. The method provided by the invention enables the purity of the extract to be high and provides four effective components of the required Radix Scutellariae for pharmacy.

Description

technical field [0001] The invention relates to the extract of Scutellaria baicalensis, which is a method for extracting four different effective components in Scutellaria baicalensis with subcritical water. Background technique [0002] Scutellaria baicalensis is a traditional Chinese medicine with high medicinal value and widely used. Scutellaria baicalensis, which is often used in traditional Chinese medicine treatment, is a raw material of Scutellaria baicalensis traditional Chinese medicine. As those skilled in the art continue to study the active ingredients in Scutellaria baicalensis. It is found that there are four active ingredients in Scutellaria baicalensis that have different effects, and can be made into different medicines for clinical use. The clinical effect is very good, and the toxic and side effects are minimal. For this reason, those skilled in the art provide a kind of active ingredient in Scutellaria baicalensis The extraction method, this method is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30C07D311/40C07H17/07C07H1/08
Inventor 程燕刘长安丁尚志李景超李赛钰徐清忠程传格刘建华
Owner SHANDONG ANALYSIS & TEST CENT
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