Rapid center control testing method of Xingnaojing injection

Abstract

The invention relates to a rapid center control testing method of Xingnaojing injection. The rapid center control testing method comprises the following steps of: (1) acquiring samples of primary distillate and secondary distillate in the preparation process of the Xingnaojing injection of different batches; (2) testing the areas of the curcuma zedoary diketone, the curcumenol and the Germacrone in the distillate samples and the total liquid phase peak areas by using a liquid chromatographic method, and testing the muscone peak areas in the distillate samples by using a gas chromatographic method; (3) acquiring near infrared spectrum data of the distillate samples; (4) constructing a model; and (5) testing the content of the curcuma zedoary diketone, the curcumenol, the Germacrone and the muscone in unknown distillate samples.

Description

technical field

[0001] The invention belongs to the field of near-infrared detection, and in particular relates to a multi-index rapid determination method for the distillation process of Xingnaojing injection. Background technique

[0002] Xingnaojing Injection is a compound Chinese medicine preparation, which is a water-soluble intravenous injection obtained through scientific distillation from the traditional Chinese medicine prescription "Angong Niuhuang Pill". After intravenous administration, it can directly act on the blood-brain barrier. Central Nervous System. The medicine is mainly composed of musk, borneol, turmeric and gardenia. Among them, musk is fragrant, good at walking and channeling, and can open all orifices. All the orifices have the function of clearing away heat and detoxification; Curcuma is bitter and cold in nature, can clear away heat and relieve fire, cool blood and detoxify, resolve phlegm and open depression, and can cooperate with two medicines...

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