Peritoneal dialysis liquid (lactate) composition and preparation method thereof

Abstract

The invention provides a peritoneal dialysis liquid (lactate) composition and a preparation method thereof. The composition comprises the following components in percentage by weight: 1.5 to 4.25 percent of glucose, 0.4 to 0.7 percent of sodium chloride, 0.02 to 0.03 percent of calcium chloride, 0.01 to 0.02 percent of magnesium chloride, and 0.4 to 0.6 percent of sodium lactate. The preparation method is characterized by, after the peritoneal dialysis liquid is subpackaged, comprising the following steps of 1) heating the subpackaged peritoneal dialysis liquid to a temperature of 115 DEG C by adopting an autoclave sterilization method, and maintaining for 5 minutes; 2) treating the peritoneal dialysis liquid with ultrasonic wave with frequency between 20 and 50kHz and intensity between 5 and 20W / cm<2> while the peritoneal dialysis liquid is heated; and 3) stopping heating and ultrasonic wave treatment when the maintenance time of the step 1) is reached, and cooling to reduce the temperature.

Description

technical field [0001] The peritoneal dialysis fluid of the present invention and its preparation method. Background technique [0002] Compared with hemodialysis, peritoneal dialysis has the advantages of wide application range, high dialysis efficiency, good preservation of residual renal function, and high quality of life of patients. It occupies an increasingly important position in the replacement therapy of chronic renal failure. The key to successful peritoneal dialysis is a well-functioning peritoneum with ultrafiltration. However, due to the long-term nature of peritoneal dialysis treatment, the ultrafiltration performance of the peritoneum is often affected by various factors and changes during the treatment process, and this change is irreversible, which will eventually cause the loss of the peritoneal ultrafiltration function of the patient, making it impossible to perform Peritoneal dialysis treatment. Traditional peritoneal dialysis solutions are mainly gluco...

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Problems solved by technology

[0003] Ultrasonic sterilization technology is a new cold sterilization technology developed in recent years. It has been applied in the fields of food, drinking water and wastewater treatment. Discussion on its mechanism of action" (Fang Xiang et al., Acoustic Technology, August 2009, Volume 28, No. 4, 491-494) disclosed that ultrasonic sterilization technology and heating synergistic sterilization have better effects on some heat-resistant bacteria did not produce a synergistic effect