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Artificial crystalline lens used for preventing and treating posterior capsule opacification and preparation method thereof

An intraocular lens and cataract technology, applied in ophthalmic surgery and other directions, can solve the problems of damage to other tissues, overflow into aqueous humor or other tissues, and unavoidable posterior cataracts, etc.

Active Publication Date: 2013-05-15
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, improvements have been made in the design of intraocular lenses to reduce the incidence of post-cataract, mainly including: (1) improving the biocompatibility of intraocular lens materials and reducing the fibrosis of the posterior capsule; The rectangular side design of the front edge prevents LEC from migrating to the visual axis, but it still cannot prevent the occurrence of posterior cataract
[0007] Among these methods, there is a kind of method that perfuses trypsin solution into the lens capsule through various instruments to kill the lens epithelial cells on the inner surface of the lens capsule. However, the disadvantage of this method is that the trypsin solution may damage the lens in advance. The hole formed by capsulorhexis overflows into the aqueous humor or other tissues, thereby damaging other tissues in the eye

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In the test, a test object made of silicone and having the shape and size equivalent to a normal intraocular lens was used as an intraocular lens.

[0029] Experimental steps:

[0030] (1) Take a beaker and wash it with Wujie powder and double distilled water. Take 3.0g of silica gel and put it into a beaker, add double distilled water, and ultrasonically clean it for 5min*3, pay attention that all the silica gel should sink to the bottom of the water.

[0031] (2) Take PBS with pH 7.0 and adjust the pH value to 7.4 with KOH. Take 50mg of trypsin + 1ml of the above PBS (pH7.4) to make a 50mg / ml enzyme solution.

[0032] (3) Take 10mg BSA + 990μl double distilled water to prepare 1% BSA solution.

[0033] (4) Take 20 μl 50% glutaraldehyde solution + 980 μl double distilled water to prepare 1% glutaraldehyde solution.

[0034] (5) Cross-linking mixing: sequentially mix 200 μl of the enzyme solution prepared in step (2), 100 μl of the 1% BSA solution prepared in step (...

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Abstract

The invention discloses an artificial crystalline lens used for preventing and / or treating posterior capsule opacification and a preparation method of the artificial crystalline lens. Trypsin is fixed on the surface of the artificial crystalline lens, namely the trypsin which has a lethal effect on crystalline lens epithelial cells is fixed on the surface of the artificial crystalline lens. Therefore, the artificial crystalline lens can selectively destroy the crystalline lens epithelial cells in a lens capsule when the artificial crystalline lens is transplanted into the lens capsule. Occurring of posterior capsular opacification is avoided.

Description

technical field [0001] The present invention relates to an intraocular lens and a preparation method thereof, more specifically, to an intraocular lens for preventing and / or treating after cataract and a preparation method thereof. The surface of the artificial lens of the present invention is immobilized with trypsin which has a killing effect on lens epithelial cells, so that when it is implanted into the lens capsule, it can selectively destroy the lens epithelial cells in the lens capsule and prevent posterior capsule opacification. Background technique [0002] Cataract removal surgery is one of the most common operations in ophthalmology. The cataract lens is located in a lens capsule. To access the cataract lens, an incision is made in the edge of the eye to allow a surgical instrument to be inserted into the anterior chamber of the eye. In extracapsular cataract extraction, a capsulorhexis procedure is performed, that is, a surgical cutting instrument is used to cre...

Claims

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Application Information

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IPC IPC(8): A61F9/007
Inventor 赵阳朱思泉李霄
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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