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Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method

A composition and arthritic technology, applied in traditional Chinese medicine composition for treating rheumatoid arthritis and preparation thereof, in the field of traditional Chinese medicine composition and preparation thereof, can solve the problems of no intellectual property rights, unknown mechanism, complex composition and the like

Inactive Publication Date: 2015-03-25
INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research in our country is still in its infancy, and most of the chemicals used in clinical practice are imported varieties without their own intellectual property rights. Although our country has unique medicinal plant resources, there are certainly many traditional Chinese medicine anti-rheumatic drugs developed from this, but due to the complexity of the ingredients, The mechanism is unknown, and it is difficult to be recognized by the world. Even the most researched Tripterygium wilfordii (Ru Lanchun T2) can only be called "alternative medicine" medicine in the West so far.

Method used

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  • Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method
  • Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method
  • Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1 Granule of the present invention

[0085] [Composition of raw materials] Clematis 3000g Chuanshanlong 4000g Papaya 2000g

[0086] 【Preparation method】Clematis chinensis, Chuanshanlong and papaya are decocted with water for 3 times, each decocting time is 1.5 hours, 1 hour, 1 hour in turn, filtered, the filtrate is combined with the above aqueous solution, and concentrated to a relative density of 1.28 (50 ℃), stir and add ethanol (to make the ethanol content reach 60%), let it stand for 24 hours to 28 hours, take the supernatant to recover ethanol, then concentrate under reduced pressure to a relative density of 1.30 (50 ℃), add 4 times the amount of water and stir Let the precipitate stand for 24 hours, take the supernatant and concentrate it under reduced pressure to a thick paste, add appropriate amount of maltodextrin (Malto Dexfrin), stevioside, dry and grind at low temperature, granulate with ethanol of appropriate concentration (50°C), 60-80 ℃ dryin...

Embodiment 2

[0087] Embodiment 2 capsules of the present invention

[0088] [Composition of raw materials] Clematis 2400g Chuanshanlong 5400g papaya 2200g

[0089] [Preparation method] Add water to decoct Clematis, Chuanshanlong, and papaya twice, each time for 2 hours, filter, combine the filtrate with the above aqueous solution, concentrate until the relative density of thermal measurement at 50°C is 1.28, stir and add ethanol to make the The amount of ethanol reaches 60%, stand still for 24 hours to 28 hours, take the supernatant to recover ethanol, then concentrate under reduced pressure to 1.30 by thermal measurement at 50°C, add 3 times the amount of water and stir to precipitate, stand still for 12 hours, take the above The clear liquid is concentrated under reduced pressure to a thick paste, and conventional auxiliary materials are added to make capsules according to the conventional process.

Embodiment 3

[0090] Embodiment 3 tablet of the present invention

[0091] [Composition of raw materials] Clematis 3600g Chuanshanlong 2600g Papaya 2800g

[0092][Preparation method] Add water to decoct Clematis clematis, Chuanshanlong, and papaya 4 times, decoct for 1.5 hours each time, filter, combine the filtrate with the above aqueous solution, concentrate to 50°C, and the thermal relative density is 1.28, stir and add ethanol to make the The amount of ethanol reaches 60%, let it stand still for 24 hours to 28 hours, take the supernatant to recover the ethanol, then concentrate it under reduced pressure to 50°C and heat the relative density of 1.30, add 5 times the amount of water and stir to precipitate, let it stand for 48 hours, take the above Concentrate the clear liquid under reduced pressure to a thick paste, add appropriate amount of auxiliary materials, dry and pulverize at low temperature, granulate with ethanol of appropriate concentration (50°C), dry at 60-80°C, granulate, an...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method, which comprises the following raw materials by weight: 10-20 parts of radix clematidis, 10-30 parts of Rhizoma Dioscoreae Nipponicae and 10-15 parts of pawpaw. The preparation method comprises the following steps: extracting radix clematidis, Rhizoma Dioscoreae Nipponicae and pawpaw.mixture by water and depositing, performing vacuum concentration to obtain the thick paste state, then adding conventional auxiliary materials to prepare the powders, tablets, granules, hard capsules and pills. The traditional Chinese medicine composition for treating rheumatoid arthritis has obvious effects on wind cold dampness and collaterals impassability due to morning stiffness of joints, pain, inflexible extension and pain in back and loin caused by rheumatoid arthritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof, belonging to the field of traditional Chinese medicine pharmacy. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic inflammation of joint synovium. At present, it is still an "intractable disease" of unknown etiology both at home and abroad. According to statistics, the average prevalence rate in the world is 1.0%, and the prevalence rate in our country is 0.32-0.36%. It is one of the main diseases that cause people to lose their labor force and become disabled. RA patients suffer tremendous pain and suffering, which is called "5D" in foreign countries, namely: discomfort, disability, dollar loss, drug reactions, and death. In severe cases, functional impairment o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P19/02A61P29/00
Inventor 王燕平
Owner INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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