42 results about "Morning stiffness" patented technology

The present invention discloses a traditional Chinese medicine composition to treat Rheumatoid Arthritis and its preparation method. The composition is mainly comprised of the following crude drugs: ant, Radix Salviae Miltiorrhizae, Radix Aconiti Preparata, Radix Ginseng, Caulis Spatholobi, and Ramulus Cinnamomi, etc. According to pharmaceutical methods, various clinical acceptable dosage forms can be prepared of the composition of the present invention, including but not limited to one of the following dosage forms: tablets, capsules, pills, granules, suspension, dripping pills, oral liquid preparation, etc. The drug of the present invention has the functions of invigorating the kidney and spleen, promoting blood flow and clearing out the vein, expelling wind-evil and removing wetness, eliminating cold to stop pain. It can be effectively used in the treatment of lingering arthralgia with weak, arthralgia, intumesce and morning stiffness, numbness and stickiness, difficult to flex and extend, rigor and deforming, the rheumatism and rheumatoid arthritis with the above symptoms.

Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical markers and / or parameters and determining a predicted risk for developing rheumatoid arthritis. Clinical markers and parameters that are decisive for the risk for developing rheumatoid arthritis may include serum levels of C-reactive protein, Rheumatoid factors, anti-CCP antibodies, anti-MCV as well as age, gender, localization of the joint complaints, length of morning stiffness, and number of tender and / or swollen joints or combinations thereof. The method may be performed by a computer. The invention further relates to a computer, a sample analyser and a computer program product for performing the method and a data carrier with the computer program product.

Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted risk for developing rheumatoid arthritis by correlating the parameter values with predefined risk values associated with ranges of parameter values. Parameters values that are decisive for the risk for developing rheumatoid arthritis may include serum levels of C-reactive protein, Rheumatoid factors, anti-CCP antibodies, as well as age, gender, localization of the joint complaints, length of morning stiffness, and number of tender and / or swollen joints. The method may be performed by a computer. The invention further relates to a computer, a sample analyser and a computer program product for performing the method and a data carrier with the computer program product.

The invention relates to a traditional Chinese medicine composition for treating local swelling and pain, belonging to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients: 10-100g of euphorbia perkinensis, 10-100g of euphorbia kansui, 10-100g of Brassica alba boiss, 4-6g of musk, 11-13g of ephedra, 29-31g of lumbricus, 17-19g of cassia twig, 8-10g of nux vomica and 29-31g of stalactite. By adopting the Chinese medicinal herb formula, the composition has the advantages of accessible materials, simple preparation method, favorable treatment effect and low price, has the effects of dispersing rheumatism, tonifying the liver and the kidney, dredging the channels and relieving numbness and pain, and is used for joint acute inflammation, morning stiffness, pain, swelling and dysfunction caused by rheumatic and rheumatoid arthritis and other rheumatic diseases.

The invention relates to a medicine for treating rheumatic arthritis and rheumatoid arthritis and a method for preparing the medicine. The medicine is mainly prepared from pharmaceuticals of polyrhachis vicina roger, zaocys dhumnades, radix aconiti preparata, radix rehmanniae, tripterygium wilfordii, radix clematidis, paniculate swallowwort root, suberect spatholobus stem, herba epimedii, anemarrhena asphodeloides, cornu cervi, buthus martensi karsch, centipede and earthworm, pseudo-ginseng, astragalus, pawpaw, herba taxilli, eucommia ulmoides, radix achyranthis bidentatae, ligusticum chuanxiong and the like. The medicine is used for treating the rheumatoid arthritis and the rheumatic arthritis of finger morning stiffness, muscle and join pain, inhibited bending and stretching, muscle emaciation and anchylosis and malformation, and has the functions of tonifying kidney and strengthening bones, activating blood and relieving wind, dispelling cold and clearing dampness, an exact curative effect and no toxic and side effects.

A traditional Chinese medicine composition for fumigating to cure rheumatism, relates to traditional Chinese medicine formulas and is characterized by consisting of the following raw materials by weight: 30 parts of caulis piperis kadsurae, 30 parts of caulis sinomenii, 30 parts of erycibe obtusifolia, 50 parts of short-pedicel aconite roots, 30 parts of thunder god vines, 30 parts of caulis trachelospermi, 10 parts of erythrina indica lam, 9 parts of ningpo yam rhizome, 9 parts of pyrola, 9 parts of folium photiniae, 9 parts of cortex acanthopanacis, 15 parts of obscured homalomena rhizome, 12 parts of golden cypress, 9 parts ofrhizoma atractylodis, 9 parts of folium artemisiae argyi, 6 parts of snow lotus herbs, 3 parts of processed radix aconiti, 3 parts of processed radix aconiti kusnezoffii, 15 parts of of garden balsam stems and 9 parts of radix clematidis. The traditional Chinese medicine formula for curing the rheumatism is easy in obtaining materials, simple in preparation method, good in curative effects, low in price and capable of achieving the functions of removing the rheumatism, nourishing liver and kidney, clearing the meridians and stopping pain and numbness, and is used for joint acute inflammation, morning stiffness, pain, swelling and functional disorder caused by rheumatism arthralgia syndrome of rheumatic arthritis, rheumatoid arthritis and the like.

The invention relates to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method, which comprises the following raw materials by weight: 10-20 parts of radix clematidis, 10-30 parts of Rhizoma Dioscoreae Nipponicae and 10-15 parts of pawpaw. The preparation method comprises the following steps: extracting radix clematidis, Rhizoma Dioscoreae Nipponicae and pawpaw.mixture by water and depositing, performing vacuum concentration to obtain the thick paste state, then adding conventional auxiliary materials to prepare the powders, tablets, granules, hard capsules and pills. The traditional Chinese medicine composition for treating rheumatoid arthritis has obvious effects on wind cold dampness and collaterals impassability due to morning stiffness of joints, pain, inflexible extension and pain in back and loin caused by rheumatoid arthritis.

The invention discloses an external-use product in Yao-nationality medicine for going through the veins, strengthening muscles and bones, passing meridian, promoting blood circulation, improving symptom of hand-foot cooling and for foot bath. The product is mainly prepared from natural and unique valuable and rare medicinal materials such as caulis spatholobi, Chinese starjasmine stem, rhizome drynariae, roots and stems of Kadsura heteroclita, rhizome zingiberis, beautiful sweetgum fruit, cinnamomum camphora, fructus evodiae and cassia twig by the ancient prescription of Yao nationality, and is an external-use product for foot bath of consumers. The product has favorable functions of going through the veins, strengthening muscles and bones, passing meridian, dispelling cold, protecting the skin, promoting blood circulation, improving cooling of hands and feet, balancing yin and yang, adjusting internal secretion, improving body fluid circulation, allaying tiredness, enhancing the nervous regulation ability, alleviating arthralgia of muscles, enhancing the immune function, improving the immunity, delighting mood, alleviating mental stress and easing sleep. The product is particularly suitable for sub-health crowds cool in hands and feet, unsmooth in qi and blood, in morning stiffness, unsmooth in meridian and cool in hands and feet.

The invention discloses a bean moxibustion treatment device which comprises a heating body. The bean moxibustion treatment device is characterized in that the heating body comprises at least one bag body and beans; different kinds of beans are selected according to different parts of a human body, and are arranged in the bag body; for the abdomen of the human body, the beans are soybeans; and for the back or head of the human body, the beans are red beans. The bean moxibustion treatment device combines conception and governor vessels and yin-yang and five elements to carry out treatment. The bean moxibustion treatment device can promote metabolism and blood circulation of the human body, adjusts the functions of the human body, enhances immunity, effectively relieves pain, numbness, insomnia, morning stiffness and other symptoms caused by rheumatoid arthritis, muscle strain, frozen shoulder and other diseases, and have some supplementary physiotherapy and health protection benefits for the rehabilitation of lumbar disc herniation, constipation, chronic gastritis, dysmenorrhea, neurasthenia, bronchitis, cerebral palsy, physical weak, cold house, diabetes and the like.

The invention discloses a medicament composition for treating rheumatoid arthritis, which is a preparation mainly prepared from the raw materials such as black ants, tripterygium wilfordii, scorpion, geranium wilfordii, rhizoma dioscoreae nipponicae, menispermaceae roots, gentiana macrophylla, turmeric and liquorice. The medicament has the advantages of simple and unique prescription, low price and remarkable efficacy. Clinical study confirms that the medicament can rapidly improve pain, swelling, morning stiffness symptoms of patients without obvious toxic-side effects. The invention also discloses a method for preparing the medicament. The medicament is obtained by grinding or extracting Chinese medicaments with solvents respectively, performing other pretreatment and then compounding the obtained products pro rata according to the different characteristics of each Chinese medicament.

The invention belongs to the technical field of health-care foods and particularly relates to a gugua polypeptide composition. The gugua polypeptide composition comprises melon seed peptide and bone marrow peptide. The invention also provides application of the gugua polypeptide composition in preparing medicines and health-care foods which have the efficacy of improving immunity, promoting woundhealing as well as preventing and treating diseases caused by free radical damage. The gugua polypeptide composition provided by the invention has the effects of effectively promoting the wound healing, improving the immunity, eliminating excess free radicals in the body, realizing an anti-aging effect, promoting calcium absorption and collagen secretion, reducing morning stiffness, increasing joint flexibility, reducing joint pain and swelling, improving diseases such as osteoporosis, fracture, rheumatism, rheumatoid, scapulohumeral periarthritis and lumbar disc herniation, improving the digestive system, promoting gastrointestinal peristalsis and digestive enzyme secretion, treating chronic gastrointestinal disease, improving pancreatic function, promoting automatic insulin secretion ofthe body and reducing insulin resistance, thereby achieving the aims of decreasing blood sugar and preventing complications.

The invention provides pharmaceutical compositions for treating rheumatic joint disease, a preparation method thereof and application thereof. The pharmaceutical compositions mainly consist of the following raw materials in parts by weight: 10-70 parts of silky ant, 10-50 parts of astragalus mongholicus, 5-40 parts of pawpaw, 5-40 parts of salted aconite root and 2-20 parts of pseudo-ginseng. The invention further provides a preparation method of the pharmaceutical compositions and the use of the pharmaceutical compositions. The experiment improves that the pharmaceutical compositions provided by the invention have the effects of deficiency tonifying, consolidating basis, eliminating evil and smoothening numbness, not only can be used for effectively treating and relieving the arthralgia, the morning stiffness, the numbness and the bad flexibility caused by the rheumatism and the rheumatoid arthritis, but also can be used for preventing, treating and relieving the kidney function harm caused by the rheumatism, have the functions for treating the pathological changes such as arthrocele, pain, inhibited bending and stretching and the like, and can be particularly used for the rheumatic arthritis, the chronic infectious arthritis, the joint synovitis and the rheumatoid renal damage.

The invention provides a cervical vertebra protective bedding which can be adjusted and particularly used for protecting cervical vertebra. The cervical vertebra protective bedding is composed of three independent portions which are a main bedding, a controllable bedding portion and a pillow bedding portion. When the main bedding and the pillow bedding portion are connected through hook & loop fasteners, a recess portion without beddings can be formed between the main bedding and the pillow bedding portion, the controllable bedding portion can be transversally put in the recess portion, a plurality of types of recess portions can be achieved through freely moving and arranging the controllable bedding portions in the recess portion, so people can comfortably put his shoulder and arm in this recess portion when he sleeps on one side. His shoulder will distinctly not be pressed because his shoulder is lower than the surface of the main bedding, his upper half body is supported on the main bedding by his chest portion under the oxter, his head can lean against the pillow in parallel because his head is closer to the pillow, his cervical vertebra will not bend and be pressed, his channels, collaterals and blood flow will be unblocked, chronic diseases such as morning stiffness, stiff neck, shoulder and back pain, cerebral anoxia, hand anaesthesia and cervical vertebra discomfort and the like will not easily occur.

The invention discloses a medicine for curing rheumatoid arthritis and a preparation method of the medicine, and belongs to the field of Chinese traditional medicines. The effective component of the medicine comprises the following raw materials: humata tyermanni moore, rhizoma rodgersiae, calamus tetradactylus, aconitum kusnezoffii, rhizoma corydalis decumbentis, dentiferous dendropanax root and stem, phlomis umbrosa, Chinese artichoke, macartney rose root, radix dipsaci, herba euonymi, thlaspi arvense, radix lithospermi, beautiful spotflower herb, poncirus trifoliata and rhizoma tupistrae chinensis. The medicine disclosed by the invention achieves the suitability for selected medicinal material compatibility, accords with the traditional Chinese medicine and pharmacy theory and the modern medicine and pharmacology theory, has the effects of relieving swelling and stopping pain, expelling wind and removing dampness, relaxing tendons and dredging collaterals, reinforcing qi and nourishing blood, can afford the sufficient nutrient substance supply to bone cells, plays a lubrication role in the joints of a whole body, achieves outstanding curative effect on the rheumatoid arthritis caused by symptoms, such as finger morning stiffness, muscle joint pain, joint stiffness and deformity, effectively restores the joint function, strengthens the physique of a human body, reduces the pain of a patient and is widely applied to the clinical therapy of the rheumatoid arthritis.

A novel use of the known protein erythropoietin (EPO), and / or a derivative, and / or a fragment thereof, is disclosed. EPO is used as a pharmaceutical for the treatment of chronic inflammations. A particularly beneficial result is seen in patients suffering from rheumatoid arthritis (RA). Significant effects are seen in clinical variables such as morning stiffness, swollen joints, and the like.

The invention discloses a medicine for treating rheumatoid arthritis and a preparation method, and belongs to the field of traditional Chinese medicine. The medicine is prepared from rhizoma smilacis chinensis, shorthairy antenoron herb, mappianthus iodoides Hand.Mazz., India madder roots, tinomiscium tonkinense Gagnep., lindera angustifolia Cheng, sarmentose pepper herb, dendropanax chevalieri (Vig.) Merr. et Chun, boxwood, radix rubiae, ampelopsis bodimeri (Levl. et Van.) Rehd., salacia prinoides (Willd.) DC., cassia twigs, calanthe tricarinata Lindl., beautiful sweetgum fruits and alpinia japonica. The medicinal materials selected for the medicine are appropriate in compatibility, complement one another, have the effects of dispelling wind and eliminating dampness, promoting qi circulation and relieving pain, relaxing the muscles and stimulating blood circulation, soothing the liver and activating the collaterals, invigorating pulse-beat, removing toxicity for detumescence and the like, and can directly reach the diseased region in cooperation, and the medicine has the advantages of being capable of taking effect fast, high in cure rate, free of toxic or side effects, safe and convenient to take for limb pain, arthrocele, lower back pain, joint pain, morning stiffness, synovial membrane inflammation, joint deformity, joint local pricking, joint erosion and other symptoms caused by rheumatoid arthritis; besides, the medicine is cheap and easy to prepare.

The invention relates to an application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis. In particular, the invention discloses polygonum cuspidatum, polydatin and emodin which can alleviate symptoms related to rheumatoid arthritis, such as arthralgia, swelling, morning stiffness and / or joint destruction.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis. The traditional Chinese medicine composition is prepared from, by weight, 10-35 parts of radix clematidis, 6-20 parts of radix saposhnikoviae, 6-12 parts of semen brassicae, 10-20 parts of honeysuckle stems, 6-12 parts of prepared stiff silkworms, 3-8 parts of medicinal scorpions, 3-8 parts of centipedes, 6-15 parts of radix angelicae, 10-30 parts of stir-fried coix seeds, 10-25 parts of rhizoma corydalis and 10-25 parts of cortex erythrinae. The basic etiology and pathogenesis of intermingled cold and heat and phlegm stagnation, numbness and obstruction of the rheumatoid arthritis are firstly summarized, the traditional Chinese medicine composition is prepared on the basis of the basic etiology and pathogenesis, and the compatible characteristics of cold-warm combination and simultaneous treatment of phlegm and blood stasis are achieved. When the traditional Chinese medicine composition is used for treating the rheumatoid arthritis, the treatment effect is sure, safety, simpliness and convenience are achieved, the effect-enhancing and toxicity-reducing effects are achieved, symptoms and signs (such as the joint pain degree, the swelling degree, the pressing pain degree, the motion degree, the grip strength and morning stiffness) can be improved, the indexes such as an anti-CCP antibody, an RF, ESR and CRP are improved, the western medicine dosage is decreased, and the illness state relapse rate is decreased.

The invention discloses a new application of methazolamide, in particular to application in preparing a medicament for treating ankylosing spondylitis. In a concrete application method, a patient orally administrates two methazolamide tablets of 25mg every day after a meal respectively in the morning and at night; and the methazolamide takes effect commonly for one month and can obviously improve and reduce BASDAI and BASFI of the ankylosing spondylitis, lighten neck ache, back ache and hip ache, reduce morning stiffness time and ache joint number and obviously lower the blood sedimentation and immune globulin level of the patient.

The invention discloses a traditional Chinese medicine preparation for treating rheumatic arthritis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The effective constituent of the traditional Chinese medicine preparation is prepared from, rhynchosia volubilis, beefwood-like clubmoss herb, chinaroot greenbrier, herb of Yunnan Ainsliaea, corkleaf snowbell leaves or roots, leaves of Chinese maple, the root of David currant, camphorwood, garden balsam stems, common dysosmatis rhizomes and roots, white mustard seeds, notopterygium roots, common cissampelos herb, herba aristolochiae, needle juniper and herb of style pachysandra. The selected medicines are appropriate in compatibility and bring out the best in one another. The traditional Chinese medicine preparation has the effects of dispelling wind and eliminating dampness, relaxing the muscles and stimulating the blood circulation, eliminating cold to stop pain, warming the middle warmer and regulating qi, promoting blood circulation to arrest pain and the like. The medicines are cooperated to directly reach the diseased region. The traditional Chinese medicine preparation has the advantages of becoming effective rapidly, being high in cure rate, having no toxic or side effect and being safe and convenient to take for treating limb or trunk numbness, wrist joint nodular protrusions, persistent back pain accompanied by morning stiffness, joint local pricking, morning stiffness, spine and limb malformation, joint pain, joint painful swelling and other symptoms caused by rheumatic arthritis, is low in price and easy to prepare and can be widely applicable to clinic treatment on rheumatic arthritis.

The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating the joint swelling pain. The traditional Chinese medicine composition is characterized by comprising, by mass, 20 g to 30 g of herba epimedii, 20 g to 30 g of radix clematidis, 20 g to 30 g of long-noded pit vipers, 20 g to 30 g of ligusticum wallichii, 20 g to 30 g of shaved cinnamon bark and 20 g to 30 g of cocklebur fruits. The traditional Chinese medicine composition has the exact and remarkable effect on symptoms, such as the swelling pain, swelling, morning stiffness, movement limitation and heat gains, caused by aggravated bi; no side effect exists during taking, and relapsing is avoided.

The invention relates to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method, which comprises the following raw materials by weight: 10-20 parts of radix clematidis, 10-30 parts of Rhizoma Dioscoreae Nipponicae and 10-15 parts of pawpaw. The preparation method comprises the following steps: extracting radix clematidis, Rhizoma Dioscoreae Nipponicae and pawpaw.mixture by water and depositing, performing vacuum concentration to obtain the thick paste state, then adding conventional auxiliary materials to prepare the powders, tablets, granules, hard capsules and pills. The traditional Chinese medicine composition for treating rheumatoid arthritis has obvious effects on wind cold dampness and collaterals impassability due to morning stiffness of joints, pain, inflexible extension and pain in back and loin caused by rheumatoid arthritis.

The invention relates to the technical field of rheumatism treatment, in particular to a rheumatism plaster and a preparation method thereof. The problems that in the prior art, most treatment methodsare mainly used for temporarily relieving arthralgia, some medicines such as analgesic such as hormones can bring a lot of toxic and side effects to patients if taken for a long time, and even causemore serious harm to the patients than rheumatism, and the rheumatism plaster comprises the following raw materials in parts by weight: asarum, monkshood, mint, cinnamon, clove, frankincense, peach kernel, safflower, fineleaf schizonepeta herb, cortex lycii radicis and cochinchinensis. The rheumatism plaster prepared by the invention can be quickly absorbed by skin, directly acts on the peripheryof the plaster, quickly increases the concentration of medicines in surrounding tissue fluid, directly increases local blood flow and accelerates metabolism of tissues, so that inflammation around thetissues is quickly reduced, and back pain and morning stiffness caused by lumbar disc herniation, arthritis and the like are effectively treated.

The invention discloses nerve-soothing footbath soup and a production process thereof. The nerve-soothing footbath soup comprises the following raw material: roxburgh peristrophe herb, radix arnebiae / radix lithospermi, herba leonuri, quassia, leaves of bupleurum chinense, wormwood, spanishneedles herb, bulbus lilii and flos chrysanthemi indici. The nerve-soothing footbath soup is prepared from thecomponents in parts by weight of 5-30 parts of roxburgh peristrophe herb, 5-30 parts of radix arnebiae / radix lithospermi, 5-30 parts of herba leonuri, 5-30 parts of quassia, 5-30 parts of leaves of bupleurum chinense, 5-30 parts of wormwood, 5-30 parts of spanishneedles herb, 10-20 parts of bulbus lilii and 10-20 parts of flos chrysanthemi indici. By virtue of the soup, muscles and bones are strengthened, meridians are dredged, bodies are warmed, cold is dispelled, skin is protected, blood circulation is promoted, and cold hands and feet are improved; yin and yang are balanced, internal secretion is adjusted, body fluid circulation of the whole body is improved, fatigue is eliminated, the neuromodulation capacity is enhanced, muscular pain is relieved, the immune function is enhanced, andimmunity is improved. The soup has the effects of achieving good mood, relieving mental stress, facilitating sleep and the like. The nerve-soothing soup is especially suitable for being used by sub-health crowds with cold hands and feet, unsmooth qi and blood, morning stiffness, blocked meridians and collaterals, cold hands and feet and the like.

The invention relates to an antineoplastic and antirheumatic traditional Chinese medicine mixture in combination with honeybee therapy and a preparation method. The antineoplastic and antirheumatic traditional Chinese medicine mixture comprises the following raw materials in parts by weight: 120 to 150 parts of mature honeys, 50 to 80 parts of fresh royal jelly, 500 to 800 parts of nori, 10 to 30parts of a propolis ethanol solution, 10 to 30 parts of bee pollen and 3 to 5 parts of queen bee larvae. According to the antineoplastic and antirheumatic traditional Chinese medicine mixture, bee venom allergy can be effectively prevented, the rate of untoward effect is obviously reduced, the mixture has a synergistic effect with bee venom acupuncture therapy in clinical effects, the symptoms such as morning stiffness, backache, cold and hot sensitivity, lower limb ponderosity, hypodynamia, constipation and aches caused by rheumatism and tumor diseases can be effectively improved, and the testing indexes such as erythrocyte sedimentation rate, acute reactive protein, immune globulin and hemameba are obviously improved; the rheumatism and tumor are resisted by strengthening the body resistance, the untoward effects of chemoradiotherapy of tumor patients are improved, the immunologic functions of antineoplastic and antirheumatic patients are improved, the mixture has the effects of reducing toxicity and increasing effect for chemoradiotherapy medicines, the living quality of patients is improved, and the lifetime of the patients is prolonged.

The invention relates to the field of traditional Chinese medicines, and discloses a rheumatism-dispelling paste. The paste comprises zaocys dhumnade, earthworms, divaricate saposhnikovia root, stephania tetrandra, Chinese starjasmine stems, kadsura pepper stems, licorice root, dried ginger, rice kernels, radix salviae miltiorrhizae, radix puerariae, radix cyathulae, radix clematidis, cortex erythrinae, rhizoma cimicifugae, cassia twigs, radix scrophulariae, rhizoma cibotii, notopterygium root, roasted tortoise plastron, asarum sieboldii, radix pseudostellariae, radix astragali, medicated leaven, radix scutellariae, ginseng and walnuts. The rheumatism-expelling paste can be used for relieving joint pain, joint swelling and pain after being taken orally, and is used for treating lumbago andback pain and morning stiffness caused by rheumatism, rheumatoid, ankylosing spondylitis and the like.