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Application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis

A technology for arthritis and rheumatoid, which is applied in the application field of Polygonum cuspidatum, polydatin, and emodin in the treatment of rheumatoid arthritis, and can solve the problems of AMPK signaling molecules not seen

Active Publication Date: 2019-08-16
DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies have found that mt-p53 plays an important role in the course of RA, but there is no report that AMPK signaling molecule is related to the pathogenesis of RA
[0005] Although Polygonum cuspidatum is commonly used clinically, and the active ingredient polydatin in Polygonum cuspidatum has been proven to have pharmacological effects such as antitussive, blood lipid lowering, antithrombotic, anti-shock, prevention and treatment of cerebral ischemia, improvement of microcirculation, and inhibition of myocardial cell contraction [Guangdong Chemical Industry ,2017,44(4):58-60.]; Emodin, the active ingredient in Polygonum cuspidatum, was reported to reduce the expression of CD34 and TNF-α in the synovial membrane of rats with collagen induced arthritis (CIA) expression, inhibits the formation of pannus [Chinese Journal of Experimental Formulas, 2015(17): 111-115.], and has antibacterial, antiviral, and blood circulation regulation functions [Acta TCM, 2011, 39(3): 103 -106.], but there is no report about Polygonum cuspidatum and its active ingredients polydatin and emodin in the prior art that have activities related to the treatment of rheumatoid arthritis

Method used

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  • Application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis
  • Application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis
  • Application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Polygonum cuspidatum is to the impact of CIA rat arthritis index (arthritis index, AI) score

[0038]The Polygonum cuspidatum decoction (50ml / bag) prepared by the above preparation method is provided by the Department of Pharmacy, Dongfang Hospital, Beijing University of Traditional Chinese Medicine. The experimental animals were 90 SPF grade male SD rats, 6 weeks old, weighing 200-220 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2012-0001). After one week of adaptive feeding, 6 rats were randomly selected as the normal group, and the remaining 84 rats were used for collagen-induced arthritis (CIA) modeling. In the initial immunization, 0.2 mL of modeling agent (bovine type II collagen, concentration 1 mg / mL) was subcutaneously injected into the base of each model rat’s tail, and 0.1 mL of Modeling agents were boosted. Models were evaluated 7 days after the booster immunization. An AI sc...

example 2

[0046] Example 2: Effect of Polygonum cuspidatum on the AMPK / mt-p53 signaling pathway in the joint synovium of CIA rats

[0047] The Polygonum cuspidatum decoction (50ml / bag) prepared by the above preparation method is provided by the Department of Pharmacy, Dongfang Hospital, Beijing University of Traditional Chinese Medicine. The experimental animals were 90 SPF grade male SD rats, 6 weeks old, weighing 200-220 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2012-0001). After one week of adaptive feeding, 6 rats were randomly selected as the normal group, and the remaining 84 rats were used for CIA modeling. At the initial immunization, 0.2 mL of modeling agent (concentration of bovine type II collagen is 1 mg / mL) was subcutaneously injected into the base of each model rat’s tail, and 0.1 mL of modeling agent was subcutaneously injected into the base of tail of each model rat 9 days later. Mold agent for booste...

Embodiment 3

[0056] After 12 weeks of intervention, the rats were anesthetized, blood was collected from the abdominal aorta, and the ankle joints were removed, fixed in 10% formalin, decalcified, embedded in paraffin, sectioned, stained with HE, and observed with a light microscope.

[0057] The experimental data were analyzed statistically using SPSS 19.0 statistical software. The results are shown in Table 3 and Figures 1A-1H.

[0058] Normal group: the articular surface is smooth, the chondrocytes are neatly arranged, and there is no inflammatory cell infiltration in the periarticular tissues;

[0059] Model group: Articular chondrocytes fell off in flakes, forming ulcers, fibrous connective tissue hyperplasia on the ulcer surface, and new blood vessels invaded; the synovium was moderately hyperplasia, and the joint cavity was shrunk; there were more fibrous tissue hyperplasia in the periarticular tissues, and different degrees were seen in the interstitium Inflammatory cell infiltrat...

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Abstract

The invention relates to an application of polygonum cuspidatum, polydatin and emodin in treatment of rheumatoid arthritis. In particular, the invention discloses polygonum cuspidatum, polydatin and emodin which can alleviate symptoms related to rheumatoid arthritis, such as arthralgia, swelling, morning stiffness and / or joint destruction.

Description

technical field [0001] The present invention relates to the application of Polygonum cuspidatum and its effective components polydatin and emodin in treating rheumatoid arthritis. Background technique [0002] Polygonum cuspidatum is the dry rhizome and root of Polygonum Cuspidatum Sieb.et Zucc, a perennial herb of the genus Polygonum, also known as Yinyang lotus, Zijinlong, bitter stick, sour stick, spotted stick, and rhubarb. It is mainly distributed in various regions south of the Yangtze River in my country and in Shaanxi, Hubei and Sichuan. The main components in Polygonum cuspidatum are anthraquinones, stilbenes, flavonoids, coumarins and some fatty acid compounds. Polydatin and emodin are the main components in Polygonum cuspidatum. [0003] Polygonum cuspidatum is a traditional Chinese medicine commonly used in my country, mainly used for the treatment of cardiovascular and tumor diseases. It has the effect of promoting dampness and reducing jaundice, clearing away...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K31/122A61K31/7034A61P19/02A61P29/00
CPCA61K36/704A61K31/122A61K31/7034A61K2300/00
Inventor 孟凤仙张惠媛卜祥伟
Owner DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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