The invention discloses a pharmaceutical composition for treatment of spleen-kidney Yang deficiency type postpartum depression and a preparation method of the pharmaceutical composition. The pharmaceutical composition is composed of flos mume, tuber fleeceflower stem, semen platycladi, schisandra chinensis, folium eriobotryae, cortex albiziae, filifolium sibiricum kitam, uncaria rhynchophylla, radix bupleuri, herba lophatheri, wheat, radix glycyrrhizae, radix codonopsis, acorus calamus, rhizoma dioscoreae colletii, caragana sinica rehd, black soybeans, rhizoma curculiginis, herba epimedii, semen astragali complanati, geranium henryi, sappanwood, herba polygalae japonicae, concha ostreae, herba salviae chinensis, root of begonia and root and rhizome of bloodred iris. The pharmaceutical composition and the preparation method thereof have the advantages that the pharmaceutical composition has a major function of treatment of spleen-kidney Yang deficiency type postpartum depression and efficacies of liver nourishing, kidney tonifying, spleen invigorating, damp clearing, Yang tonifying and blood circulation promoting and is remarkable in curative effect, free of toxic and side effects, low in cost, convenient to take, effective in control of disease development and less prone to prognosis superinfection, direct action to the focus of infection is realized, and a production process is simple and convenient.