Use of tetrahydropyridines in preparing medicine for treating hepatitis or hepatocirrhosis

Abstract

The invention discloses novel application for Ectoine, namely application of the Ectoine in preparing medicines of treating hepatitis or hepatocirrhosis. The effective dosage range of the Ectoine is 0.1 to 100 mg / kg of body weight, preferably 8 to 50mg / kg of the body weight. When in use, the Ectoine adopts a mode of intravenous infusion. The experiment implemented by the inventor proves that the Ectoine can protect hepatic tissue, and inhibit the reduction of albumin, other proteins, amino acid, thrombozyme and profibrinolysin in liver and serum when the hepatitis and the hepatocirrhosis develop, thereby maintaining normal colloid osmotic pressure, delaying the generation of ascites, improving the content of RNA in the liver and achieving the aims of protecting the liver and controlling the growth of the disease of the hepatitis and the hepatocirrhosis. The Ectoine can be used for assisting treatment of the hepatitis and the hepatocirrhosis.

Description

technical field

[0001] The invention relates to the application of ectoine in the preparation of medicines for treating hepatitis or liver cirrhosis. Background technique

[0002] Hepatitis is an inflammation of the liver. There are many pathogenic factors, such as drug-induced hepatitis, autoimmune hepatitis, alcoholic hepatitis, and viral hepatitis. Drug metabolism is mostly completed by the endoplasmic reticulum in liver cells. The liver is not only the main site of drug metabolism, but also the main target organ of drug toxicity. If a certain type of drug is used for too long, the dose is too large, or patients with specific constitutions, it may cause liver damage; especially for patients with liver insufficiency, the possibility of damage is greater, and the resulting harmfulness Also relatively larger. Viral hepatitis is caused by hepatitis virus, mainly to damage the liver infectious disease, including A, B, C, D, E viral hepatitis. Viral hepatitis accounts for t...

Examples

Embodiment 1

[0011] Example 1: Research on the Effects of Ectrahydropyrimidine on Rat Liver RNA Content

[0012] 20 Wistar rats were randomly divided into 2 groups. The control group was given intragastric administration of 2ml normal saline, and the experimental group was given intragastric administration of ectoine saline solution (the dose of ectoine was 10 mg / kg body weight). / kg intraperitoneal injection 3 H-cytidine, the rats were sacrificed 48 hours after injection, and the liver was taken to measure the liver RNA content.

[0013] The results showed that the RNA content in the liver tissue of the rats in the treatment group was 2.3 times that of the control group (58.9mg / g vs 25.6mg / g), indicating that ectoine can increase the RNA content in the liver and has a good protective effect on hepatitis and cirrhosis .

Embodiment 2

[0014] Example 2: Effect of ectoine on liver albumin, prothrombinase and plasminogen levels in rats with liver cirrhosis Divided into two groups, each group of 10 rats, the control group was given intragastric administration of 2ml normal saline, and the experimental group was given intragastric administration of ectoine saline solution (the dose of ectoine was 30 mg / kg body weight), and 48 hours after the administration, the rats were sacrificed. The liver was taken to measure the levels of liver albumin, prothrombinase and plasminogen. The levels of albumin, thromboplastin, and plasminogen in the liver of rats in the experimental group were significantly higher than those in the control group, which were 39.46g / L vs 30.08g / L; 12.24g / L vs 5.57g / L; 54.92U / L vs 69.73U / L, each group compared with the normal group, P<0.05. The test results show that ectoine has a significant protective effect on liver cirrhosis, and is beneficial to maintaining normal colloid osmotic pressure an...

technical field

[0001] The invention relates to the application of ectoine in the preparation of medicines for treating hepatitis or liver cirrhosis. Background technique

[0002] Hepatitis is an inflammation of the liver. There are many pathogenic factors, such as drug-induced hepatitis, autoimmune hepatitis, alcoholic hepatitis, and viral hepatitis. Drug metabolism is mostly completed by the endoplasmic reticulum in liver cells. The liver is not only the main site of drug metabolism, but also the main target organ of drug toxicity. If a certain type of drug is used for too long, the dose is too large, or patients with specific constitutions, it may cause liver damage; especially for patients with liver insufficiency, the possibility of damage is greater, and the resulting harmfulness Also relatively larger. Viral hepatitis is caused by hepatitis virus, mainly to damage the liver infectious disease, including A, B, C, D, E viral hepatitis. Viral hepatitis accounts for t...

Examples

Embodiment 1

[0011] Example 1: Research on the Effects of Ectrahydropyrimidine on Rat Liver RNA Content

[0012] 20 Wistar rats were randomly divided into 2 groups. The control group was given intragastric administration of 2ml normal saline, and the experimental group was given intragastric administration of ectoine saline solution (the dose of ectoine was 10 mg / kg body weight). / kg intraperitoneal injection 3 H-cytidine, the rats were sacrificed 48 hours after injection, and the liver was taken to measure the liver RNA content.

[0013] The results showed that the RNA content in the liver tissue of the rats in the treatment group was 2.3 times that of the control group (58.9mg / g vs 25.6mg / g), indicating that ectoine can increase the RNA content in the liver and has a good protective effect on hepatitis and cirrhosis .

Embodiment 2

[0014] Example 2: Effect of ectoine on liver albumin, prothrombinase and plasminogen levels in rats with liver cirrhosis Divided into two groups, each group of 10 rats, the control group was given intragastric administration of 2ml normal saline, and the experimental group was given intragastric administration of ectoine saline solution (the dose of ectoine was 30 mg / kg body weight), and 48 hours after the administration, the rats were sacrificed. The liver was taken to measure the levels of liver albumin, prothrombinase and plasminogen. The levels of albumin, thromboplastin, and plasminogen in the liver of rats in the experimental group were significantly higher than those in the control group, which were 39.46g / L vs 30.08g / L; 12.24g / L vs 5.57g / L; 54.92U / L vs 69.73U / L, each group compared with the normal group, P<0.05. The test results show that ectoine has a significant protective effect on liver cirrhosis, and is beneficial to maintaining normal colloid osmotic pressure an...