Composition for preventing and/or treating rheumatoid arthritis as well as preparation method and application thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a composition for preventing and/or treating rheumatoid arthritis and a preparation method and application thereof. The composition for preventing and/or treating rheumatoid arthritis is prepared from the following raw material components in parts by mass: 5-30 parts of notopterygium root, 5-45 parts of kadsura pepper stem, 3-20 parts of prepared monkshood, 5-30 parts of gentiana macrophylla, 5-30 parts of mulberry twig, 5-30 parts of angelica sinensis, 5-20 parts of ligusticum wallichii, 3-15 parts of elecampane and 3-30 parts of honey-fried licorice root. Clinical tests prove that the composition for preventing and/or treating rheumatoid arthritis can improve the joint swelling and pain symptom of a patient and control the inflammation level and disease progression, and has a potential bone protection effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to a composition for preventing and / or treating rheumatoid arthritis, a preparation method and application thereof. Background technique [0002] Rheumatoid arthritis (RA) is a common autoimmune disease, and its pathological features are joint synovial inflammation and synovial tissue hyperplasia, which in turn leads to damage and destruction of articular cartilage and bone. In the natural course of rheumatoid arthritis, the disability rate is 60% in 5 to 10 years, and 90% in 30 years. The bone destruction caused by the inflammation and hyperplasia of the synovial membrane is the core pathological link of rheumatoid arthritis, so how to effectively block the bone destruction and reduce the disability rate is a difficult point to be overcome in the treatment of rheumatoid arthritis. [0003] Although Western medicine treatment can effectively control the diseas...

AI Technical Summary

Problems solved by technology

[0003] Although western medicine treatment can effectively control the disease in the short term, it is still not fully effective in stabilizing the disease for a long time, especially it cannot effectively prevent the progress of imaging studies (that is, prevent the progress of bone destruction)

Antirheumatic drugs (DMARDs) such as methotrexate (MTX) are the first-line treatment drugs for RA. Early, adequate, and combined use of DMARDs is the key to improving the prognosis of RA, but 40% of patients do not respond to early induction remission regimens. Moreover, the long-term clinical application of DMARDs is greatly limited due to their side effects and poor tolerance such as gastrointestinal symptoms, bone marrow suppression, hepatotoxicity, nephrotoxicity, infection, tumor and autonomic neuropathy, and even patients' resistance

Although new DMARDs, such as biological agents, continue to make progress, due to the single-target effect, there are still problems such as rapid short-term efficacy, unstable long-term efficacy, easy recurrence of patients' conditions, and incomplete safety. heavy financial burden on patients and society

At present, DMARDs, including biological agents, cannot effectively block or inhibit the pathological process of joint bone destruction in RA patients, resulting in continuous progression of imaging changes despite treatment

[0004] RA belongs to the category of "bi syndrome" in traditional Chinese medicine. Classical prescriptions such as Huangqi Guizhi Wuwu Decoction (Astragalus, Guizhi, Paeoniae Alba, Ginger and Jujube) or Guizhi Shaoyao Zhimu Decoction (Cinnamon Twig, Peony, Licorice, Ephedra , Ginger, Atractylodes macrocephala, Anemarrhena, Fangfeng and Sunburn Fuzi) are used to treat rheumatoid arthritis, but the therapeutic effect is not very satisfactory

In addition, for example, the Chinese patent application with publication number CN 108578606 A discloses a traditional Chinese medicine preparation for treating rheumatoid arthritis, which consists of astragalus 35, cassia twig 15, fried white peony root 25, sunburnt aconite 10, angelica 15, coix seed 25, Composed of Fangfeng 15, Gentiana 15, Notopterygium 10, Chuanxiong 10, Atractylodes 15, and Licorice 15, it has a certain therapeutic effect on rheumatoid, but whether it can block or inhibit the pathological process of joint bone destruction in RA patients still needs to be further explored

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