Use of tetrahydropyridines in preparing medicine for treating hepatitis or hepatocirrhosis
A technology for tetrahydropyrimidine and liver cirrhosis, which is applied in the application field of tetrahydropyrimidine in the preparation of medicines for treating hepatitis or liver cirrhosis, and can solve problems such as undiscovered tetrahydropyrimidine.
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Embodiment 1
[0011] Example 1: Research on the Effects of Ectrahydropyrimidine on Rat Liver RNA Content
[0012] 20 Wistar rats were randomly divided into 2 groups. The control group was given intragastric administration of 2ml normal saline, and the experimental group was given intragastric administration of ectoine saline solution (the dose of ectoine was 10 mg / kg body weight). / kg intraperitoneal injection 3 H-cytidine, the rats were sacrificed 48 hours after injection, and the liver was taken to measure the liver RNA content.
[0013] The results showed that the RNA content in the liver tissue of the rats in the treatment group was 2.3 times that of the control group (58.9mg / g vs 25.6mg / g), indicating that ectoine can increase the RNA content in the liver and has a good protective effect on hepatitis and cirrhosis .
Embodiment 2
[0014] Example 2: Effect of ectoine on liver albumin, prothrombinase and plasminogen levels in rats with liver cirrhosis
[0015] 20 Wistar rats were intraperitoneally injected with 40 mg / kg DMN to induce liver cirrhosis. After successful modeling, they were randomly divided into two groups, 10 rats in each group. The control group was given 2ml normal saline, and the experimental group was given ectoine saline solution (The dose of ectoine is 30 mg / kg body weight). 48 hours after administration, the rats were sacrificed, and the liver was taken to measure the levels of liver albumin, thromboplastin and plasminogen. The levels of albumin, thromboplastin, and plasminogen in the liver of rats in the experimental group were significantly higher than those in the control group, which were 39.46g / L vs 30.08g / L; 12.24g / L vs 5.57g / L; 54.92U / L vs 69.73U / L, each group compared with the normal group, P<0.05. The test results show that ectoine has a significant protective effect on live...
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