Application of methazolamide in preparing medicament for treating ankylosing spondylitis
Ankylosing spondylitis, methazolamide technology, applied in the application field of medicine, can solve problems such as kidney damage, spine and tendon end disease, poor effect, synovial membrane effect rarely reported, etc.
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Embodiment 1
[0025] Example 1: In order to explore the pathogenesis of ankylosing spondylitis, the inventors of the present invention used proteomics technology to study the synovial tissue of patients with ankylosing spondylitis.
[0026] In order to discover the specific pathogenic protein factors of ankylosing spondylitis, synovial tissues of osteoarthritis and rheumatoid arthritis were used as controls. Osteoarthritis is degenerative bone damage in the elderly, and rheumatoid arthritis is an autoimmune disease. Although both are manifested as arthritis, using the two as a control can effectively remove proteins that are only related to bone damage and immunity, and find proteins specifically expressed in ankylosing spondylitis. It is rare to compare three diseases at the same time in proteomics research.
[0027] Methods: Firstly, the total protein of diseased synovial tissue (10 specimens for each disease) was extracted according to the conventional method, and the protein concentrat...
Embodiment 2
[0034] Embodiment 2: clinical treatment
[0035] Patient Information: Two patients with ankylosing spondylitis (referred to as patient S and patient L) were screened. The patients were at similar stages of disease progression. The diagnosis was based on the New York criteria revised in 1984. The above two patients met the characteristics of mid-stage ankylosing spondylitis according to the following staging diagnostic criteria, namely ① Pain in the neck, back, waist, hip, knee, shoulder, sternoclavicular joint, intercostal nerve, sacrohip joint, limited mobility, and mild ②X-ray films showed destruction of the sacrohip joint surface, blurred joint edges, and narrowed gaps; ③Laboratory tests showed increased erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). All three criteria are met. The patient had no history, symptoms or sequelae of iritis, and the rheumatoid factor RF was negative. The patient had previously received the above-mentioned conventional tre...
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