Application of methazolamide in preparing medicament for treating ankylosing spondylitis

Ankylosing spondylitis, methazolamide technology, applied in the application field of medicine, can solve problems such as kidney damage, spine and tendon end disease, poor effect, synovial membrane effect rarely reported, etc.

Inactive Publication Date: 2010-07-28
常晓天 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have side effects such as edema, hematuria, gastrointestinal reactions and kidney damage
[0006] (2) Sulfasalzine (SSZ): This type of drug is an azo compound of 5-aminosalicylic acid and sulfapyridine, which is mainly effective for the peripheral joints of patients, but not effective for spinal and tendinopathy
However, so far, most of the studies on ankylosing spondylitis have focused on the diseased bone tissue, and there are few reports on the role of the synovium in the disease.

Method used

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  • Application of methazolamide in preparing medicament for treating ankylosing spondylitis
  • Application of methazolamide in preparing medicament for treating ankylosing spondylitis
  • Application of methazolamide in preparing medicament for treating ankylosing spondylitis

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Effect test

Embodiment 1

[0025] Example 1: In order to explore the pathogenesis of ankylosing spondylitis, the inventors of the present invention used proteomics technology to study the synovial tissue of patients with ankylosing spondylitis.

[0026] In order to discover the specific pathogenic protein factors of ankylosing spondylitis, synovial tissues of osteoarthritis and rheumatoid arthritis were used as controls. Osteoarthritis is degenerative bone damage in the elderly, and rheumatoid arthritis is an autoimmune disease. Although both are manifested as arthritis, using the two as a control can effectively remove proteins that are only related to bone damage and immunity, and find proteins specifically expressed in ankylosing spondylitis. It is rare to compare three diseases at the same time in proteomics research.

[0027] Methods: Firstly, the total protein of diseased synovial tissue (10 specimens for each disease) was extracted according to the conventional method, and the protein concentrat...

Embodiment 2

[0034] Embodiment 2: clinical treatment

[0035] Patient Information: Two patients with ankylosing spondylitis (referred to as patient S and patient L) were screened. The patients were at similar stages of disease progression. The diagnosis was based on the New York criteria revised in 1984. The above two patients met the characteristics of mid-stage ankylosing spondylitis according to the following staging diagnostic criteria, namely ① Pain in the neck, back, waist, hip, knee, shoulder, sternoclavicular joint, intercostal nerve, sacrohip joint, limited mobility, and mild ②X-ray films showed destruction of the sacrohip joint surface, blurred joint edges, and narrowed gaps; ③Laboratory tests showed increased erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). All three criteria are met. The patient had no history, symptoms or sequelae of iritis, and the rheumatoid factor RF was negative. The patient had previously received the above-mentioned conventional tre...

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Abstract

The invention discloses a new application of methazolamide, in particular to application in preparing a medicament for treating ankylosing spondylitis. In a concrete application method, a patient orally administrates two methazolamide tablets of 25mg every day after a meal respectively in the morning and at night; and the methazolamide takes effect commonly for one month and can obviously improve and reduce BASDAI and BASFI of the ankylosing spondylitis, lighten neck ache, back ache and hip ache, reduce morning stiffness time and ache joint number and obviously lower the blood sedimentation and immune globulin level of the patient.

Description

technical field [0001] The invention relates to a new medical application of methazolamide, namely the application in the preparation of medicine for treating ankylosing spondylitis. Background technique [0002] Ankylosing spondylitis (AS) is a connective tissue disease characterized by chronic inflammation of the axial joints, mainly involving the spine and sacroiliac joints, leading to joint fibrosis and bony ankylosis, eventually leading to deformities. The disease can also involve internal organs and other tissues leading to chronic progressive rheumatism. Ankylosing spondylitis is more common in young men aged 16 to 30, and the incidence rate varies greatly in different regions and different races. The incidence rate of ankylosing spondylitis in my country is 0.3%. [0003] Clinically, patients with ankylosing spondylitis present with polyarticular lesions, and most of them first invade the sacroiliac joints and then develop upward to the cervical spine. In a small ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/433A61P29/00A61P19/04A61P19/02
Inventor 常晓天张云忠闫新峰韩金祥
Owner 常晓天
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