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Pharmaceutical compositions for treating rheumatic joint disease, preparation method thereof and use thereof

A joint disease and composition technology, applied in the field of pharmaceutical compositions, can solve the problems of unsatisfactory results, poor oral activity, unsatisfactory therapeutic effect and the like

Inactive Publication Date: 2013-01-30
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The International League Against Rheumatism divides the existing anti-rheumatic drugs into two categories, namely anti-rheumatic drugs for improving symptoms and anti-rheumatic drugs for disease control. Rheumatism drugs are often used in combination in clinical practice in order to achieve the purpose of disease control, but in terms of the short-term and long-term curative effects obtained so far, the results are not satisfactory; although biological therapy has been carried out in recent years, it is expensive and oral The shortcomings of poor activity and inability to selectively act on target tissues limit its application; gene therapy seems to be able to overcome some of the defects of biological therapy in theory, but in more than 300 clinical studies in the world, more than 3,000 patients who have received gene therapy , none clearly demonstrated clinical improvement
Existing clinical drugs such as salicylic acid and other non-steroidal anti-inflammatory drugs, antimalarials, penicillamine, tripterygium preparations, gold preparations, and even corticosteroids have unsatisfactory therapeutic effects and large side effects

Method used

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  • Pharmaceutical compositions for treating rheumatic joint disease, preparation method thereof and use thereof
  • Pharmaceutical compositions for treating rheumatic joint disease, preparation method thereof and use thereof
  • Pharmaceutical compositions for treating rheumatic joint disease, preparation method thereof and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0269] Composition of prescription raw materials: black ant 3000g, astragalus 2000g, papaya 1500g, salt aconite 1200g, notoginseng 600g

[0270] Take the prescribed amount of raw materials, black ants, salt aconite, astragalus and papaya, and crush them into coarse powder, soak in distilled water for 30 minutes, add 6 times the amount of water and fry three times, each time for 1 hour, filter, and the filtrate is concentrated to a relative density of 1.07 (60°C) clear ointment for later use; additionally take the prescribed amount of notoginseng, crush it, and pass through a 120-mesh sieve to obtain ultra-fine powder of notoginseng, mix the ultra-fine powder of notoginseng with the clear ointment obtained from the above extraction, and add The above-acceptable excipients are made into granules according to the conventional technology of preparation in the art.

[0271] Every gram of the granule of the present invention is equivalent to 6 grams of crude drug.

Embodiment 2

[0273] Composition of prescription raw materials: black ant 3000g, astragalus 2000g, papaya 1500g, salt aconite 1200g, notoginseng 600g

[0274] Get the raw material medicine of the present invention of prescription quantity, black ant, salt aconite, Radix Astragali, Panax notoginseng and Chinese papaya are pulverized, pass 24 mesh sieves, obtain raw material coarse powder; Place raw material coarse powder in the oven of 60 ℃ and dry 5h, take out, Ensure that the moisture content of the feed should be lower than 4%; carry out ultrafine grinding on the dried coarse powder, the grinding time is 20 minutes, and the particle size is about 8 μm ultrafine powder.

[0275] Each gram of the ultrafine powder of the present invention is equivalent to 1 gram of crude drug.

Embodiment 3

[0277] Composition of prescription raw materials: black ant 2500g, astragalus 3000g, papaya 1200g, salt aconite 2000, notoginseng 500g

[0278] Get the crude drug of the present invention of recipe quantity, black ant, salt aconite, Radix Astragali, Panax notoginseng and papaya pulverize, cross 24 mesh sieves, get raw material coarse powder, add 10 times of amount 70% ethanol back flow extraction three times, each 1.5 hours , filter, combine the filtrates, and recover ethanol until there is no alcohol smell; the filtrate passes through the macroporous resin, and is first eluted with 5 times the amount of water, and the eluent is discarded, and then eluted with 70% ethanol, and the eluent is collected and reduced. Press to recover the ethanol until there is no alcohol smell; then add pharmaceutically acceptable auxiliary materials and make tablets according to the conventional technology of preparation in the art.

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Abstract

The invention provides pharmaceutical compositions for treating rheumatic joint disease, a preparation method thereof and application thereof. The pharmaceutical compositions mainly consist of the following raw materials in parts by weight: 10-70 parts of silky ant, 10-50 parts of astragalus mongholicus, 5-40 parts of pawpaw, 5-40 parts of salted aconite root and 2-20 parts of pseudo-ginseng. The invention further provides a preparation method of the pharmaceutical compositions and the use of the pharmaceutical compositions. The experiment improves that the pharmaceutical compositions provided by the invention have the effects of deficiency tonifying, consolidating basis, eliminating evil and smoothening numbness, not only can be used for effectively treating and relieving the arthralgia, the morning stiffness, the numbness and the bad flexibility caused by the rheumatism and the rheumatoid arthritis, but also can be used for preventing, treating and relieving the kidney function harm caused by the rheumatism, have the functions for treating the pathological changes such as arthrocele, pain, inhibited bending and stretching and the like, and can be particularly used for the rheumatic arthritis, the chronic infectious arthritis, the joint synovitis and the rheumatoid renal damage.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition composed of black ants, salt aconite, astragalus, papaya and notoginseng, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) belongs to the category of "arthritis syndrome" in Chinese medicine, with a high incidence rate, most of which are young adults aged 25 to 55, and the incidence rate of women is higher than that of men, with a male to female ratio of 1:4. There are hundreds of millions of patients worldwide. According to statistics, the prevalence rate of RA in foreign countries is 1-2%, and it is as high as 5% in some regions; the incidence rate in my country is about 0.74%, and there are about 15 million patients; 50% of rheumatoid arthritis patients become disabled in two years, and 70% in three years. The average life expectancy of patients with rheum...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61P19/02A61P29/00A61P13/12A61K35/64
Inventor 徐世军
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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