Guangdong purple pearl volatile oil extract, its preparation method, pharmaceutical composition containing it and use

A technology of volatile oils and extracts, applied in the field of traditional Chinese medicine or natural medicine pharmaceuticals, can solve the problems of no in vitro antibacterial activity, no in vitro antibacterial activity of Guangdong Zizhu volatile oil components, etc., and achieve strong anti-Staphylococcus aureus effect

Active Publication Date: 2015-10-21
JIANGSU KANION PHARMA CO LTD +2
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] The prior art related to the present invention mainly contains the following 3 documents: 1. Chen Duanduan, Chen Huifang. Comparative observation of curative effect of Baofukang Suppository and Nudehua Zizhu Suppository in the treatment of candidal vaginitis. Practical Integrative Chinese and Western Medicine Clinic. 2006, 6(2): 28-29. This article is mainly about the clinical observation of two kinds of traditional Chinese medicine suppositories in the treatment of candida vaginitis. There is no description about the preparation of the volatile oil components of Guangdong Zizhu and its antibacterial activity in vitro
2. Su Xueli, Zhu Shukui. Analysis of several main volatile chemical components of Zizhu. Journal of Jingmen Vocational and Technical College. 2008, 23(3): 7-10. GC-MS analysis of volatile components, no description of the preparation of the volatile oil components of Guangdong Zizhu and its in vitro antibacterial activity
3. Hong Yanlong. Preparation process, quality standard and chemical composition of Guangdong Zizhu effervescent tablets. Beijing: Beijing University of Traditional Chinese Medicine, 2004. This article verified the anti-inflammatory activity of Guangdong Zizhu total flavonoids by in vivo experiments , studied the chemical constituents of Guangdong Zizhu flavonoids, obtained two compounds from them, and investigated the preparation process and quality standards of Fuyankang effervescent tablets, but did not describe the preparation of the volatile oil components of Guangdong Zizhu and its in vitro antibacterial activity

Method used

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  • Guangdong purple pearl volatile oil extract, its preparation method, pharmaceutical composition containing it and use
  • Guangdong purple pearl volatile oil extract, its preparation method, pharmaceutical composition containing it and use
  • Guangdong purple pearl volatile oil extract, its preparation method, pharmaceutical composition containing it and use

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Embodiment 1

[0036] Embodiment 1: the preparation of Guangdong purple bead volatile oil extract

[0037] Take the medicinal material Guangdong Zizhu, crush it, and pass through a 24-mesh sieve. Weigh 200g, put it in a 2000ml flask, add 800ml of water and count glass beads, connect the volatile oil detector and condensing device, and extract for 6h. The obtained volatile oil is a light yellow transparent clear oil with aroma, extracted with anhydrous ether, and dehydrated with an appropriate amount of anhydrous sodium sulfate to obtain the volatile oil. The yield of volatile oil extracted in this embodiment is 0.615%.

Embodiment 2

[0039] Take the medicinal material Guangdong Zizhu, crush it, and pass through a 24-mesh sieve. Weigh 200g, put it in a 2000ml flask, add 600ml of water and count glass beads, connect the volatile oil detector and condensing device, and extract for 3h. The obtained volatile oil is a light yellow transparent clear oil with aroma, extracted with n-hexane, and dehydrated with an appropriate amount of anhydrous sodium sulfate to obtain the volatile oil. The yield of volatile oil extracted in this embodiment is 0.420%.

Embodiment 3

[0041]Take the medicinal material Guangdong Zizhu, crush it, and pass through a 24-mesh sieve. Weigh 200g, put it in a 2000ml flask, add 1200ml of water and count glass beads, connect a volatile oil detector and a condensing device, and extract for 7 hours. The obtained volatile oil is a light yellow transparent clear oil with aroma, extracted with anhydrous ether, and dehydrated with an appropriate amount of anhydrous sodium sulfate to obtain the volatile oil. The yield of volatile oil extracted in this embodiment is 0.741%.

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Abstract

The invention provides a Callicarpa kwangtungensis chun. essential oil extract, which is characterized by comprising 1.2-2.9% of aliphatic acid compound and 45.0-55.0% terpene component. The invention also provides a preparation method of the Callicarpa kwangtungensis chun. essential oil extract, a pharmaceutical composition containing the Callicarpa kwangtungensis chun. essential oil extract, and an application.

Description

technical field [0001] The present invention belongs to the pharmaceutical field of traditional Chinese medicine or natural medicine, and in particular relates to a Guangdong purple pearl volatile oil extract, a preparation method thereof, a composition containing the Guangdong purple pearl volatile oil extract and its use for inhibiting cervicitis pathogenic bacteria . Background technique [0002] The survey of Chinese women by the World Health Organization shows that the population of women of childbearing age in my country is about 150-200 million, of which about 41% of women suffer from gynecological inflammatory diseases to varying degrees, and the incidence rate of married women is as high as 70%. According to statistics, cervicitis accounts for about 40-50% of the total number of obstetrics and gynecology outpatients, ranking first among gynecological diseases, and chronic cervicitis accounts for 10%-25% of outpatients. Under normal circumstances, cervical glands ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B9/02A61K36/85A61P31/04A61P31/10
Inventor 杨义芳贾安
Owner JIANGSU KANION PHARMA CO LTD
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