Medical use of milkvetch root total saponin

A technology of total astragalus saponins and astragaloside IV, applied in the field of medicine and health care products

Active Publication Date: 2013-09-11
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report about total saponins of astragalus improving memory in normal mice

Method used

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  • Medical use of milkvetch root total saponin
  • Medical use of milkvetch root total saponin
  • Medical use of milkvetch root total saponin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: Preparation of total astragalus saponins of the present invention

[0070] Experimental materials: Radix Astragali was purchased from Shanghai Gaoqiao Yanghetang Pharmacy; organic reagents such as ethanol and n-butanol were of analytical grade and were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0071] experimental method:

[0072] Astragalus membranaceus 5kg was placed in a CTG-10 extractor and extracted twice with 70% ethanol under reflux, adding 10 times the amount for the first time and 8 times the amount for the second time, 1 hour each time. The extracts were combined, ethanol was recovered under reduced pressure, and concentrated to 10 L. Extract 3 times with water-saturated n-butanol (1:1), combine n-butanol fractions, recover n-butanol extract and concentrate to about 1 L.

[0073] Slowly add the concentrated extract to the treated D101 resin column (7.5cm×95cm resin height 64cm), first elute with 4 times column volume of distilled wat...

Embodiment 2

[0075] Embodiment 2: Preparation of Astragalus total saponins of the present invention

[0076] Experimental materials: Radix Astragali was purchased from Shanghai Gaoqiao Yanghetang Pharmacy; organic reagents such as ethanol and n-butanol were of analytical grade and were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0077] experimental method:

[0078] Astragalus 5kg was placed in a CTG-10 extractor, extracted twice with 70% ethanol under reflux, adding 10 times the amount for the first time, and 8 times the amount for the second time, 2 hours each time. The extracts were combined, ethanol was recovered under reduced pressure, and concentrated to 10 L. Extract twice with water-saturated n-butanol (1:1), combine the n-butanol fractions, recover the n-butanol extract and concentrate to about 1 L.

[0079] Slowly add the concentrated extract to the treated D101 resin column (7.5cm×95cm resin height 64cm), first elute with 3 times column volume of distilled water to re...

Embodiment 3

[0081] Embodiment 3: Preparation of total astragalus saponins of the present invention

[0082] Experimental materials: Radix Astragali was purchased from Shanghai Gaoqiao Yanghetang Pharmacy; organic reagents such as ethanol and n-butanol were of analytical grade and were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0083] experimental method:

[0084] Astragalus membranaceus 5kg was placed in a CTG-10 extractor and extracted twice with 70% ethanol under reflux, adding 10 times the amount for the first time and 8 times the amount for the second time, 3 hours each time. The extracts were combined, ethanol was recovered under reduced pressure, and concentrated to 10 L. Extract 3 times with water-saturated n-butanol (1:1), combine n-butanol fractions, recover n-butanol extract and concentrate to about 1 L.

[0085] Slowly add the concentrated extract to the treated D101 resin column (7.5cm×95cm resin height 64cm), first elute with 4 times column volume of distilled wa...

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PUM

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Abstract

The invention relates to the field of medicine, particularly to a medical use, a drug composition and a health product of milkvetch root total saponin. The milkvetch root total saponin can be used for preparing a drug or a health product for improving memory of normal people.

Description

technical field [0001] The invention relates to the field of medical and health care products, in particular to the medical application of total astragalus saponins and its pharmaceutical composition and health care products. Background technique [0002] Knowledge acquired through learning must be stored in a certain way and retrieved after a period of time in order to lead to a change in individual behavior. This "access" process is what we call memory. According to the time required between accesses, people usually roughly divide memory into short-term memory and long-term memory. The time scale of short-term memory (also known as working memory) is generally seconds to minutes, limited by cognitive processes such as attention. Short-term memory generally stores only small amounts of information. Under certain circumstances, information stored in the short-term memory system can be transferred to the long-term memory system, where it can be strengthened and consolidate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A23L1/29A61P25/00A23L33/00
Inventor 吴晓俊王峥涛胡之璧黄菲
Owner SHANGHAI UNIV OF T C M
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