Radioactive particles for treating tumor and implantation method

A technology of radioactive particles and radioisotopes, used in radiotherapy, in vivo radioactive preparations, treatment, etc., can solve the problems of large damage to patients, inability to achieve conformal implantation, inability to select and change the direction and location of implantation, etc. The effect of good flexibility

Inactive Publication Date: 2013-09-18
吴沛宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of tumor treatment, it is often necessary to implant radiation particles in multiple directions and distribute them in multiple parts of the tumor, so it is necessary to implement multi-channel puncture particle implantation, that is, multiple percutaneous puncture points, multiple puncture needles and tubes are required. Multiple puncture needle cores, more instruments used, inconvenient distribution and operation, great damage to patients, and high treatment costs
[0004]2) For tumors in special locations, such as retro-rib or retrosternal tumors blocked by bones, intracranial tumors, and tumors in parts with more peripheral blood vessels and intestines, such as Pancreatic tumors, etc., it is difficult for the implantation needles of the prior art to reach the desired position, so it cannot be implemented and operated
[0005]3) The direction and site of implantation cannot be selected and changed, so it is difficult to adapt to the shape of the tumor and cannot achieve conformal implantation
However, the head of this new particle implantation device is a curved needle, that is, a curved needle. The rigid cylindrical 125I radioactive particles in the prior art cannot pass through the curved part of the curved needle. Therefore need to improve the radioactive particle of prior art, provide a kind of new 125I radioactive particle

Method used

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  • Radioactive particles for treating tumor and implantation method
  • Radioactive particles for treating tumor and implantation method
  • Radioactive particles for treating tumor and implantation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: The radioactive particles of the spring connection type of the present invention

[0028] refer to figure 1 , In this embodiment, a spring-connected radioactive particle of the present invention is disclosed, and the radioactive particle includes a rigid unit 1 and an elastic unit 2 . The rigid unit 1 contains a sealed casing 12 , metal particles 11 and radioisotopes 13 . radioisotope selection 125 I.

[0029] The elastic unit 2 is a helical spring made of titanium-nickel shape memory alloy wire, the diameter of the wire is 0.20mm, the outer diameter of the helical spring is 0.70mm, and the length of the helical spring segment is 1.5mm.

[0030] The metal particle 11 of the rigid unit 1 is a silver ball with a diameter of 0.5mm, and the center of the silver ball has a through hole with a diameter of 0.25mm. The function of the through hole is to facilitate the insertion of the metal wire of the helical spring as the elastic unit 2 and to fix it by rive...

Embodiment 2

[0041] Embodiment 2: The radioactive particles of the silk connection type of the present invention

[0042] In this embodiment, it is basically the same as that of Embodiment 1, the difference being that the elastic unit 2 directly adopts an elastic metal wire, such as a titanium-nickel shape memory alloy wire with a diameter of 0.3 mm, to connect each rigid unit 1 together , the manufacturing cost of this structure is lower, and it can also meet the clinical requirements, refer to Figure 5 .

Embodiment 3

[0043] Embodiment 3: Implantation method of radioactive particles of the present invention

[0044] Put the radioactive particles of the present invention into a special particle implanter. When the particles pass through the curved arc of the implanter, the elastic unit 2 of the particle will be deformed to adapt to the curved needle tube of the implanter. The radioactive particles of the invention can be compliant The release is performed by bending the arc segment, refer to Figure 6 .

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PUM

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Abstract

The invention relates to radioactive particles for treating a tumor. The radioactive particles comprise rigidity units and elastic units, wherein the rigidity units internally contain radioactive isotopes which are capable of treating the tumor, the elastic units are elastic bodies which can deform under the action of an external force and can recover the shape after the external force is withdrawn, and each elastic unit is positioned between every two rigidity units and is respectively connected with the rigidity units at two ends. Each elastic unit is arranged between every two rigidity units, the elastic unit can be bent and deform, thus the radioactive particles have good flexibility and can be released through a complicated curved pipeline, and the requirements of implanting conformal radioactive particles in a tumor clinically can be met.

Description

technical field [0001] The invention relates to a radioactive particle, especially an implanted radioactive particle for treating tumors. Background technique [0002] by implanting 125 I, that is, I (iodine) 125 radioactive particles to treat tumors, has become one of the effective methods for the treatment of solid tumors. prior art 125 The typical structure of an I radioactive particle is as follows: 125 I is adsorbed on a silver metal rod with a diameter of 0.5mm and a length of 3.5mm, and then this adsorbed 125 The silver rod of I is packaged in a titanium thin-walled tube with an outer diameter of 0.8 mm and a length of 4.5 mm. Due to this prior art 125 I radioactive particles are rigid cylinders, so they can only be placed through a straight needle implanter. Repeated puncture of the tumor part is required to form effective radioactivity distribution and coverage. There is following shortcoming in this prior art: [0003] 1) One radioactive seed implantation ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M36/04A61K51/00A61K101/02A61K103/00A61K103/36
Inventor 吴沛宏周星罗丽飞吕昭平惠希东陈晓华朱明
Owner 吴沛宏
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