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Quilted implantable graft

A technology of surgical grafts and extracellular matrix, which is applied in the field of implantable natural biomaterials, and can solve problems such as difficult grafts to be sutured to proper positions

Active Publication Date: 2013-09-18
COOK BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A potential problem with these multilayer structures is that during handling after hydration, the bonded layers can sometimes partially delaminate, which can make it more difficult for the graft to be sutured into place

Method used

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  • Quilted implantable graft
  • Quilted implantable graft
  • Quilted implantable graft

Examples

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Embodiment Construction

[0034] Although the present invention can be implemented in many different forms, in order to facilitate the understanding of the principles of the present invention, reference will now be made to the embodiments shown in the drawings, and specific language will be used to describe the embodiments shown in the drawings. However, it should be understood that no limitation of the scope of the invention is therefore intended. Any changes and further modifications of the described embodiments and any further applications of the principles of the present invention described herein are generally anticipated by those skilled in the art to which the present invention belongs.

[0035] Such as Figure 1-9 As shown in the examples, the present invention includes an implantable surgical graft 10 for repairing or strengthening tissue, wherein the graft includes a remodelable collagen sheet material 11 (for example, obtained intact from animal or human sources, and Multiple layers 12) proces...

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Abstract

Described is an embodiment of a multilaminate or multiple layers of implantable surgical graft. The graft of the embodiment comprises a remodelable collagenous sheet material, and one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

Description

[0001] Cross references to related applications [0002] This application is a continuation of U.S. Application No. 12 / 965,205 filed on December 10, 2010, which is incorporated herein by reference. Technical field [0003] The present invention generally relates to implantable natural biomaterials used to enhance and / or rebuild natural tissues. Background technique [0004] Remodelable tissue grafts obtained from mammalian sources as whole sheets and processed to remove cell debris advantageously maintain the natural structure of the extracellular collagen matrix (ECM). This matrix of collagen fibers provides a scaffold to promote and support tissue ingrowth, especially in bioactive graft materials that are processed to maintain effective levels of growth factors and other components that stimulate angiogenesis, such as the submucosa of the pig small intestine or SIS ( Biodesign TM , Cook Medical, Bloomington, Indiana). [0005] Although biomaterials derived from flakes advantageou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36
CPCA61L27/50A61L31/005A61L27/3629A61L27/3633A61F2/02A61F2/0063A61F2/0077A61L27/3625
Inventor U·H·帕特尔J·米勒N·E·费恩诺M·W·布莱尔
Owner COOK BIOTECH
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