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Application of pingyangmycin combined sodium hyaluronate in medicine for treating venous malformation

A technology of sodium hyaluronate and pingyangmycin is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulations, which can solve the problems of short residence time, large dosage, and increased side effects, and achieve inhibition of proliferation. , the effect of promoting apoptosis and enhancing apoptosis

Inactive Publication Date: 2013-10-09
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In areas with rich blood flow such as the head and neck, the simple application of Pingyangmycin will result in a large dosage due to its short residence time in the lesion, and the risk of side effects will also increase.

Method used

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  • Application of pingyangmycin combined sodium hyaluronate in medicine for treating venous malformation
  • Application of pingyangmycin combined sodium hyaluronate in medicine for treating venous malformation
  • Application of pingyangmycin combined sodium hyaluronate in medicine for treating venous malformation

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Embodiment 1

[0035] The preparation of a kind of medicine that is used for the treatment of venous malformation involved in the present invention:

[0036] Take pingyangmycin 0.1 mg, sodium hyaluronate 4 mg, add pharmaceutically acceptable carrier for preparation of injection, and prepare 10 mL injection. Because the liquid in the tumor cannot be completely pumped out and replaced with drugs of this concentration, the dosage of Pingyangmycin and sodium hyaluronate can be adjusted appropriately so that the actual amount of Pingyangmycin and sodium hyaluronate entering the tumor The concentration is about 10μg / mL and 400μg / mL.

[0037] Sodium hyaluronate is commercially available sodium hyaluronate injection, Shandong Bausch & Lomb Freda Pharmaceutical Co., Ltd., approval number: National Drug Accreditation H10960136.

[0038] The following pharmacodynamic experiments will further illustrate its drug activity.

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Abstract

The invention discloses application of pingyangmycin combined sodium hyaluronate in a medicine for treating venous malformation and a medicine for treating venous malformation, in particular relates to a medicine for treating venous malformation of head and neck. The molecular weight of the sodium hyaluronate is 600,000-1,500,000 Dalton; the concentrations of the pingyangmycin and the sodium hyaluronate are 10 mg / mL and 400 mug / mL respectively.

Description

technical field [0001] The invention relates to the application of pingyangmycin combined with sodium hyaluronate in the treatment of venous malformation. Background technique [0002] Venous malformation (VM), formerly known as cavernous hemangioma, is a low-velocity vascular malformation consisting of locally dilated veins that grow in proportion to the body and develop gradually throughout life without spontaneous regression. About 40% of them occur in the head and neck, which not only affects the face, but if it oppresses and invades adjacent tissue structures, it will affect the functions of language, swallowing and breathing. In severe cases, there is a risk of suffocation and death. Its treatment method is numerous, and modern medicine advocates to select the appropriate treatment method according to the patient's specific state of an illness. [0003] The pathogenesis of venous malformation is still unclear, and TIE2 receptor mutations, autosomal 9P site mutations, ...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61K31/728A61P35/00
Inventor 刘少华刘怡然陈健王磊
Owner SHANDONG UNIV QILU HOSPITAL
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