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Novel use of aesculetin

A kind of technology of qintedrin and medicine, which is applied in the new application field of qintedrine

Inactive Publication Date: 2013-10-23
INST OF BASIC THEORY OF TCM CHINA ACADEMY OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the treatment of osteoporosis with acetaminophen

Method used

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  • Novel use of aesculetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The preparation of embodiment 1 granule

[0076] Get 10 g of teretin B, add dextrin and make granules according to the conventional process. The daily dosage is 54-62mg / kg, twice a day.

Embodiment 2

[0077] The preparation of embodiment 2 powder

[0078] Take acetaminophen, lactose-hydrate, corn starch, and magnesium stearate in a weight ratio of 1:16:5:0.3, and make a powder according to a conventional method.

Embodiment 3

[0080] Get 4.2 g of acetaminophen, pack into No. 0-1 capsules according to the conventional process, and make capsules. 6-8 capsules per day, twice a day.

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Abstract

The invention discloses an application of aesculetin in preparation of a medicine for treating osteoporosis. The aesculetin provided by the invention can be used for obviously improving the bone mass level of an ovariectomized rate osteoporosis animal model, and simultaneously reducing the activity of an osteoclast, thereby proving that the aesculetin has an obvious treatment effect on the post-menopause osteoporosis.

Description

technical field [0001] The present invention relates to the new application of teretin, in particular to the application of teretin in the preparation of medicaments for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic metabolic bone disease characterized by low bone mass and microarchitectural degeneration of bone tissue, accompanied by increased bone fragility, decreased bone strength, and susceptibility to fracture. With the aging of human society, the incidence of osteoporosis is increasing, especially in postmenopausal women, the incidence of osteoporosis and fracture complications is higher. Therefore, the prevention and treatment of osteoporosis has gradually become an important issue for the elderly, especially the postmenopausal women. [0003] The pathogenesis of osteoproliferation is due to bone resorption exceeding bone formation. Human bones, like other tissues, are constantly undergoing metabolism, that is, bone remodeling....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P19/10
Inventor 刘丽梅鞠大宏柏冬王瑞海刘梅洁
Owner INST OF BASIC THEORY OF TCM CHINA ACADEMY OF CHINESE MEDICAL SCI