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Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method of medicament

A technology of composition and medicine, which is applied in the direction of cardiovascular system diseases, drug combination, medical formula, etc., can solve the problems of insufficient strength, unclear active ingredients, difficult to use, etc.

Inactive Publication Date: 2013-10-30
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are only a small number of single preparations and compound preparations composed of two effective parts in traditional Chinese medicines for the treatment of stroke. For example, Danshen + Chuanxiong with application numbers 200310103833 and 200710127787 obtained from patent retrieval, ginseng + Chuanxiong with application number 200410065378, Ginseng + Danshen with application numbers 200510021321 and 200410074598, but most of them have the disadvantages of insufficient efforts in the pathological improvement of ischemic cerebrovascular disease and unclear functional components, resulting in clinical It is difficult to use it alone, and there are certain limitations

Method used

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  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method of medicament
  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method of medicament
  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method of medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Ginseng total saponins 35g Salvianolic acid 20g Ligustrazine hydrochloride 20g

[0060] Take ligustrazine hydrochloride and add appropriate amount of water for injection to dissolve to obtain solution A; take salvianolic acid and add appropriate amount of water for injection to dissolve, adjust the pH value to 6-7, stir and dissolve to obtain solution B; keep stirring, add solution A to the solution In B, adjust the pH value to 6-7 to obtain solution C; take total ginsenosides and appropriate amount of mannitol, add water for injection and stir to dissolve, mix with solution C, stir evenly, and adjust the pH value to 6-7, add water for injection To quantification, activated carbon adsorption, filtration, microporous membrane filtration, sub-packaging, freeze-drying, to obtain sterile powder for injection.

Embodiment 2

[0062] Total Ginseng Saponins 50g Salvianolic Acids 10g Ligustrazine 8g

[0063] Take ligustrazine and add appropriate amount of water for injection to dissolve to obtain solution A; take salvianolic acid and add appropriate amount of water for injection to dissolve, adjust the pH value to 6-7, stir and dissolve to obtain solution B; keep stirring, add solution A to solution B and adjust the pH value to 6-7 to obtain solution C; take total ginsenosides and an appropriate amount of mannitol, add water for injection and stir to dissolve, mix with solution C, stir evenly, and adjust the pH value to 6-7, add water for injection to Quantitative, active carbon adsorption, filtration, microporous membrane filtration, sub-packaging, freeze-drying to obtain sterile powder for injection.

Embodiment 3

[0065] Ginseng total saponins 20g Salvianolic acid 30g Ligustrazine phosphate 30g

[0066] Take ligustrazine phosphate and add appropriate amount of water for injection to dissolve to obtain solution A; take total salvianolic acid and add appropriate amount of water for injection to dissolve, adjust the pH value to 6-7, stir and dissolve to obtain solution B; keep stirring, add solution A to the solution In B, adjust the pH value to 6-7 to obtain solution C; take total ginsenosides and appropriate amount of mannitol, add water for injection and stir to dissolve, mix with solution C, stir evenly, and adjust the pH value to 6-7, add water for injection To quantification, activated carbon adsorption, filtration, microporous membrane filtration, sub-packaging, freeze-drying, to obtain sterile powder for injection.

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Abstract

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases and a preparation method of the medicament. The medicament is prepared from a ginseng extract, a red-rooted salvia root extract and a hemlock parsley extract according to a certain weight proportion, wherein the ginseng extract, the red-rooted salvia root and the hemlock parsley extract can be obtained by commercial way or extracted from medicinal materials. The medicament can be prepared to form an arbitrary pharmaceutically acceptable preparation, preferably pills. The medicament has effects of tonifying qi and activating blood circulation, can be used for treating cardiovascular and cerebrovascular diseases, in particular treating acute and early recovery phase of cerebral thrombosis, cerebral ischemia, cerebral infarction and other ischemic cerebrovascular diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, especially for treating ischemic encephalopathy, and belongs to the field of traditional Chinese medicine. Background technique [0002] Cerebral ischemia, also known as ischemic stroke or cerebral infarction, belongs to the category of stroke in traditional Chinese medicine. Ischemic brain injury includes primary injury during the ischemic period and secondary injury during the reperfusion period. The initial link in the pathological process is ischemia, and the restoration of blood perfusion in the brain tissue is the basis of its treatment, but the secondary injury after reperfusion Sexual damage is inevitable. Ischemic cerebrovascular disease is extremely harmful. Statistics show that among the 57 countries, 40 countries rank the mortality rate of ischemic cerebrovascular disease in the top three, among ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/00A61P9/10A61K31/4965
Inventor 张保献胡杰张永丽
Owner BEIJING INCREASEPHARM CORP LTD
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