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Application of compound in preparation of antituberculosis medicament

An anti-tuberculosis and compound technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Features, expanding types, and the effect of broad application prospects

Inactive Publication Date: 2013-12-11
杨文君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of compound in preparation of antituberculosis medicament
  • Application of compound in preparation of antituberculosis medicament
  • Application of compound in preparation of antituberculosis medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound Phyllanthoid A tablet involved in the present invention:

[0014] Take 5 grams of compound Phyllanthoid A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Phyllanthoid A capsules involved in the present invention:

[0016] Take 5 grams of compound Phyllanthoid A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

experiment example 1

[0017] Experimental Example 1: Determination of Phyllanthoid A Anti-BCG Absolute Concentration by Solid Medium Dilution Method

[0018] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, dubbed 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0019] Make Phyllanthoid A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Phyllanthoid A to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Phyllanthoid A, the concentrations are 6.0ug / ml, 4.0ug / ml, 3.0ug...

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Abstract

The invention discloses application of Phyllanthoid A in preparation of an antituberculosis medicament. The Phyllanthoid A is discovered to have an obvious effect of inhibiting the activity of mycobacterium tuberculosis and have excellent application prospect aiming at the current situation that the current incidence of tuberculosis is high and multiple-resistant strains of the mycobacterium tuberculosis occur, so that the incidence of tuberculosis and death rate are increased.

Description

technical field [0001] The present invention relates to a new application of compound Phyllanthoid A, in particular to the application of Phyllanthoid A in the preparation of anti-tuberculosis drugs. Background technique [0002] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. work caused great difficulty. Therefore, finding new anti-tuberculosis drugs, especially anti-multidrug resistance anti-tuberculosis drugs, is of great significance to protect people's health. [0003] The compound Phyllanthoid A involved in the present invention is a new compound published in 2013 (Jian-Qiang Zhao, et al., Two ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P31/06
Inventor 杨文君
Owner 杨文君
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