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Application of traditional Chinese medicine composition in preparation of anti-tuberculin medicine

A technology of anti-tuberculosis and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of anti-tuberculosis drugs, can solve the problems of non-standard treatment and management of tuberculosis patients and difficulties in tuberculosis prevention and control, and achieve strong anti-tuberculosis and anti-tuberculosis The effect of anti-drug-resistant tuberculosis activity, highlighting substantive characteristics, and expanding species

Inactive Publication Date: 2015-08-05
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of traditional Chinese medicine composition in preparation of anti-tuberculin medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Take 18 parts of Agaricus argentina root, 15 parts of chicken kidney ginseng, 20 parts of Tongjing flower, 12 parts of chaotic tree, and 20 parts of Juhuacao, add water to decoct 2 times, and the amount of water added for the first time is 10 parts of the weight of the medicinal material. Double the amount, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal material, decoct for 1 hour, combine the decoction, concentrate, dry, and pulverize to obtain Chinese medicine composition granules. The concentration conditions are: 0.07MPa, 60- Concentrate under reduced pressure at 70°C to 65°C with a relative density of 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0015] Embodiment 2: solid medium dilution method is measured the anti-BCG (BCG) absolute concentration of Chinese medicine composition

[0016] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0017] 2. Method: Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube ( MacFarland No.1) turbidity, that is, to prepare 1 mg / ml Bacillus Calmette-Guerin (BCG) bacterial suspension. The Chinese medicine composition is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Chinese medicine composition is added to 4ml Middlebrook7H11 agar according to the required dose Culture medium (the culture medium has been steril...

experiment example 2

[0020] Experimental Example 2 Determination of Absolute Concentration of Anti-tuberculosis Mycobacterium Standard Strain H37Rv Strain by Solid Medium Dilution Method

[0021] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0022] 2. Method: Scrape the culture of Mycobacterium tuberculosis standard strain H37Rv from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate vigorously on a vortex shaker, grind with the standard Turbidimetric tube (MacFarland No.1) was used to measure the turbidity, that is, to prepare a 1 mg / ml H37Rv strain suspension.

[0023] The traditional Chinese medicine composition is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Chinese medicine composition is added to 4ml Middlebrook7H11 according to the required ...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of anti-tuberculin medicine. The traditional Chinese medicine composition is prepared by 18 parts of hairyvein agrimony roots, 15 parts of frog orchid tuber, 20 parts of common aeschynomene leaf flower, 12 parts of litsea glutinosa and 20 parts of floscopa scandens. The traditional Chinese medicine composition has remarkable effect of inhibiting activity of tuberculin and meanwhile brings remarkable progress on prevention and control of tuberculin injection.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of anti-tuberculosis drugs. Background technique [0002] According to the estimation of the World Health Organization (WHO), the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, and 5-10% of the infected people become tuberculosis patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment and management of tuberculosis p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P31/06
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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