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Application of Isocycloartobiloxanthone in preparing drug for treating tubercle bacilli

An anti-tuberculosis and drug technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Strong activity, prominent substantive features, and the effect of expanding categories

Inactive Publication Date: 2016-03-09
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of Isocycloartobiloxanthone in preparing drug for treating tubercle bacilli
  • Application of Isocycloartobiloxanthone in preparing drug for treating tubercle bacilli
  • Application of Isocycloartobiloxanthone in preparing drug for treating tubercle bacilli

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Isocycloartobiloxanthone tablet involved in the present invention:

[0014] Take 5 grams of compound Isocycloartobiloxanthone, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Isocycloartobiloxanthone capsules involved in the present invention:

[0016] Get 5 grams of compound Isocycloartobiloxanthone, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

experiment example 1

[0017] Experimental Example 1: Determination of the Absolute Concentration of Isocycloartobiloxanthone Anti-Bacillus Calmette-Guerin (BCG) by Solid Medium Dilution Method

[0018] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0019] Isocycloartobiloxanthone is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Isocycloartobiloxanthone is added to 4mlMiddlebrook7H11 agar medium according to the required dose (the culture The base has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed ev...

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Abstract

The invention discloses application of Isocycloartobiloxanthone in preparing a drug for treating tubercle bacilli. According to the situation that the morbidity of tuberculosis is high, mycobacterium tuberculosis multi-drug resistant strains occur, and the morbidity and the death rate of the tubercle bacilli are on the rise, it is found that the Isocycloartobiloxanthone has the activity of obviously inhibiting the tubercle bacilli, and a good application prospect is achieved.

Description

technical field [0001] The present invention relates to a new application of compound Isocycloartobiloxanthone, in particular to the application of Isocycloartobiloxanthone in the preparation of anti-tuberculosis drugs. Background technique [0002] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. work caused great difficulty. Therefore, finding new anti-tuberculosis drugs, especially anti-multidrug resistance anti-tuberculosis drugs, is of great significance to protect people's health. [0003] The compound Isocycloartobiloxanthone involved in the present invention is a new compound published in 2013 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/06
CPCA61K31/352
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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