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Application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine

An anti-tuberculosis and drug technology, applied in antibacterial drugs, organic chemistry and other directions, can solve the problems of difficult tuberculosis prevention and treatment, and the treatment and management of tuberculosis patients is not very standardized, and achieves strong tuberculosis inhibitory activity, outstanding substantive characteristics, The effect of widening the variety

Inactive Publication Date: 2016-02-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine
  • Application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine
  • Application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of the compound Foveospirolide tablet involved in the present invention:

[0016] Get 20 grams of compound Foveospirolide, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0017] Embodiment 2: the preparation of compound Foveospirolide capsules involved in the present invention:

[0018] Get 20 grams of compound Foveospirolide, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and make 1000 capsules.

experiment example 1

[0019] Experimental Example 1 Solid Medium Dilution Method Determination of Foveospirolide Anti-Bacillus Calmette-Guerin (BCG) Absolute Concentration

[0020] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0021] Foveospirolide is made into high-concentration stock solution with DMSO, dilutes stock solution to required concentration with 5% Tween-80 sterile ultrapure water, and the diluted Foveospirolide is added to 4mlMiddlebrook7H11 agar medium by required dosage (this culture Base has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly to make Foveospirolide, the concentrations are 6.0ug / ml, 4.0ug / ml, 3...

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Abstract

The invention discloses application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine. For the situation that current tuberculosis morbidity is high, mycobacterium tuberculosis multiple-resistant strains appear and tuberculosis morbidity and the death rate are increased, it is found that Foveospirolide has remarkable activity for restraining tubercle bacillus and has quite good application prospects. The application of Foveospirolide in preparation of tubercle bacillus treating and resisting medicine is disclosed for the first time; due to the fact that the framework type belongs to a brand-new framework type, Foveospirolide is unexpectedly high in tubercle bacillus restraining activity, no other compounds give any prompts, remarkable substantive features are achieved, and meanwhile Foveospirolide obviously has a remarkable progress for preventing and treating tuberculous infection.

Description

technical field [0001] The present invention relates to a new application of the compound Foveospirolide, in particular to the application of Foveospirolide in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, and 5-10% of them are infected. become tuberculosis patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P31/06C07D493/10
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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