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High-sensitivity, high-reproducibility surface-enhanced Raman spectroscopy detection method and device

A surface-enhanced Raman and detection method technology, applied in the field of molecular spectroscopy analysis and detection, can solve the problems of poor reproducibility, low repeatability of detection results, affecting the application of substrates, etc., and achieves low cost, high reproducibility analysis sensitivity, The effect of short detection period

Active Publication Date: 2015-12-23
胡建明
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Problems solved by technology

However, due to the roughness of the base layer of the substrate, irregular mutations in a certain range will appear after SERS irradiation and reflection, so the detection has a certain degree of discreteness and poor reproducibility, resulting in repeated accuracy of detection results. Not high, affecting the application of the substrate

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  • High-sensitivity, high-reproducibility surface-enhanced Raman spectroscopy detection method and device
  • High-sensitivity, high-reproducibility surface-enhanced Raman spectroscopy detection method and device
  • High-sensitivity, high-reproducibility surface-enhanced Raman spectroscopy detection method and device

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Embodiment Construction

[0030] The detection method of the highly sensitive and highly reproducible surface-enhanced Raman spectroscopy of the present embodiment comprises the following steps:

[0031] a. The sample to be tested is evenly coated on the SERS substrate; the coating method can be distributed in a point-like multi-point or in a planar shape;

[0032] b. Using a light source to irradiate one point of the sample to be tested on the SERS substrate through the lighting system and obtaining its Raman spectrum; using surface-enhanced Raman spectroscopy to obtain the content of the sample belongs to the prior art, and will not be repeated here;

[0033] c. carry out multi-point detection to the sample in the range that has sample on SERS substrate and repeat step b;

[0034] d. Use the acquired spectral information of the multi-point sample to be tested, calculate the average value after removing the background, and remove the minimum and maximum values ​​from the measured spectral information ...

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Abstract

The invention discloses a detection method and device for high-sensitivity and high-reproducibility surface enhanced Raman spectroscopy. The method that detection is performed repeatedly to obtain the average value is adopted, the problem of relatively high discreteness in the existing detection method is avoided, the method and the device have high reproducibility and ultrahigh analytical sensitivity, and are suitable for detection of ultratrace samples, detection results can be obtained accurately, the operation is simple, and the detection period is short. According to the method, a fine-tuning device is adopted, so that the movement of a substrate is achieved so as to perform multi-point detection, the device is simple in structure, lower in cost, and easy and convenient to operate; the method and the device provide conditions for further promoting the SERS technology to be widely used in the fields of homeland security, environmental monitoring, food safety, health care and the like.

Description

technical field [0001] The invention relates to the field of molecular spectrum analysis and detection, in particular to a detection method and device for surface-enhanced Raman spectroscopy with high sensitivity and high reproducibility. Background technique [0002] In order to solve the problem of low sensitivity of the Raman effect in the field of detection and analysis in the prior art, a surface-enhanced Raman spectroscopy analysis technology has emerged. Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity spectroscopic analysis technique developed with the development of nanotechnology in the 1990s. Like Raman spectroscopy, SERS can be used to accurately and qualitatively identify samples. SERS has ultra-high analytical sensitivity, which is about 6-10 orders of magnitude higher than that of ordinary Raman analysis, and can analyze research objects ranging from single molecules to large cells. [0003] In practical applications, directly dropping sample...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 胡建明
Owner 胡建明
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