Pathology application of schizocapsa total saponins

Abstract

The invention relates to pathology application of schizocapsa total saponins in preparing medicine for treating liver damage secondary to diabetes. The schizocapsa total saponins is capable of inhibiting CYP2E1specifically so as to treat liver function damages secondary to the diabetes, and is a hepatoprotective medicine with high medical and economic value.

Description

Technical field

[0001] The invention relates to medical pathology, in particular to the use of the total saponins of the yam yam in the preparation of a medicine for treating the liver function damage secondary to diabetes. Background technique

[0002] The liver is the body's main organ for the transformation and metabolism of various substances. It expresses a variety of enzyme systems involved in substance metabolism, the most important of which is cytochrome P450 (CYPs). In CYPs, subtype 2E1 (CYP2E1) mainly metabolizes small molecule compounds, including a variety of drugs, halogenated hydrocarbons, alcohols, ketones, and endogenous substances such as arachidonic acid and fatty acids. CYP2E1 is considered to be an important determinant that affects the body's sensitivity to various toxins and carcinogenicity, especially in mediating liver damage. It is known that in the liver lobules, the expression level of CYP2E1 in hepatocytes located around the central vein is 30 times h...

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