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Applications of nicotinamide adenine dinucleotide (NAD<+>) in preparation of medicine used for curing liver damages caused by chemotherapy drug doxorubicin hydrochloride

A technology of nicotinamide adenine and doxorubicin hydrochloride, which is applied in the field of application of nicotinamide adenine dinucleotide in the preparation of drugs for the prevention and treatment of liver damage induced by the chemotherapy drug doxorubicin hydrochloride, and can solve problems such as liver damage

Inactive Publication Date: 2014-02-12
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
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Problems solved by technology

Long-term clinical use of doxorubicin can easily cause liver damage

Method used

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  • Applications of nicotinamide adenine dinucleotide (NAD&lt;+&gt;) in preparation of medicine used for curing liver damages caused by chemotherapy drug doxorubicin hydrochloride
  • Applications of nicotinamide adenine dinucleotide (NAD&lt;+&gt;) in preparation of medicine used for curing liver damages caused by chemotherapy drug doxorubicin hydrochloride
  • Applications of nicotinamide adenine dinucleotide (NAD&lt;+&gt;) in preparation of medicine used for curing liver damages caused by chemotherapy drug doxorubicin hydrochloride

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Embodiment Construction

[0021] The experimental content of the present invention on the application of nicotinamide adenine dinucleotide in the preparation of drugs for the prevention and treatment of liver injury induced by the chemotherapy drug doxorubicin hydrochloride mainly includes the following aspects:

[0022] 1.NAD + It has a protective effect on the increase of serum alanine aminotransferase ALT caused by the chemotherapy drug doxorubicin hydrochloride.

[0023] 2.NAD + It has a protective effect on the increase of serum aspartate aminotransferase AST caused by the chemotherapy drug doxorubicin hydrochloride.

[0024] 3. NAD + It has a protective effect on the reduction of reduced glutathione GSH in liver tissue caused by doxorubicin hydrochloride.

[0025] The following pharmacodynamic experiments further illustrate NAD + It has obvious therapeutic effect in the prevention and treatment of liver injury induced by chemotherapy drug doxorubicin.

[0026] 1. Experimental method

[0027...

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Abstract

The invention relates to applications of nicotinamide adenine dinucleotide in the field of pharmacy, and more specifically relates to applications of nicotinamide adenine dinucleotide in preparation of a medicine used for curing liver damages caused by chemotherapy drug doxorubicin hydrochloride. NAD<+> is capable of preventing and treating liver damages caused by chemotherapy drug doxorubicin hydrochloride effectively; and it is also found that NAD<+> is capable of killing glioma cells, neuronal tumor cells, gastric cancer cells, renal tumor cells or breast tumor cells effectively, but possesses no killing effect on normal primary cells.

Description

technical field [0001] The present invention relates to the application of nicotinamide adenine dinucleotide in the field of pharmacy, more specifically the application of nicotinamide adenine dinucleotide in the preparation of drugs for preventing and treating liver damage induced by chemotherapy drug doxorubicin hydrochloride. Background technique [0002] Nicotinamide adenine dinucleotide (NAD for short) + ) chemical structure formula is: [0003] [0004] The preparation method of nicotinamide adenine dinucleotide mainly uses yeast as raw material, the yeast is extracted by boiling water, the crude product is acidified and precipitated with lead acetate, and the crude product is processed and refined by formic acid type cation exchange resin column. [0005] The chemotherapy drug doxorubicin hydrochloride is used to treat leukemia, malignant lymphoma, multiple myeloma, breast cancer, lung cancer, soft tissue sarcoma, gastric cancer, liver cancer, colorectal cancer, o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7084A61P1/16
Inventor 殷卫海马英鑫王班古宏晨王璐
Owner SHANGHAI JIAO TONG UNIV
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