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Rehmannia glutinosa superfine powder decoction pieces and its preparation method and application
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A technology of ultra-fine powder and powder decoction pieces, which is applied in the direction of powder transportation, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effect of fast speed, short time, and improved dissolution rate and leaching rate
Active Publication Date: 2015-12-02
康美药业(昆明)种质资源有限公司
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[0011] This method of preparing micropowder increases the process of high-temperature leaching. At the same time, in the process of leaching and filtering, many medicinal ingredients are filtered out, which makes the medicinal ingredients quite different from the original decoction pieces. This product may tend to be more traditional Chinese medicine. Micronized extract, not micronized decoction pieces, and the later ultrafine pulverization process also introduces the disadvantages of mechanical pulverization
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Embodiment 1
[0045] 1 Material pretreatment
[0046] 1.1 Material drying
[0047] Dry rehmannia glutinosa with vacuum microwave drying equipment, the microwave parameters are vacuum degree -0.70~-0.95MPa, microwave power 1~5KW, temperature 40~60°C, dry until the water content is below 5.5% by weight, and let it cool.
[0048] 1.2 Material crushing
[0049] The dried rehmannia glutinosa is pulverized into fine powder with a Cutingmill pulverizer, sieved, and set aside.
[0050] 1.3 Initial homogenate
[0051] 1.3.1 Investigation of solid-liquid ratio
[0052] Mix Shudi fine powder with water at a weight ratio of 1:4, 1:6, 1:8, 1:10, and 1:12, adjust the speed of the high-shear emulsifier to "F" (25,000rpm), and mix well Slurry for 5 minutes, observe the state of the slurry and measure the particle size distribution to ensure that the particle size of the material after the initial homogenization is less than 50 μm. As a result, when the speed of the homogenizer is selected at a higher l...
Embodiment 2
[0081] Embodiment 2 and the comparison of dissolution rate and leaching rate of traditional decoction pieces
[0082] 1 Determination of the dissolution rate of verbascoside
[0083] 1.1 Method
[0084] According to the liquid phase condition method under the first part of the "Chinese Pharmacopoeia" 2010 edition, octadecylsilane bonded silica gel is used as filler; acetonitrile-0.1% acetic acid solution (16:84) is used as mobile phase; detection wavelength 334nm. The number of theoretical plates should not be less than 5000 based on the peak of verbascoside.
[0085] 1.2 Preparation of reference solution
[0086] Accurately weigh an appropriate amount of verbascoside reference substance, accurately weigh it, add mobile phase to make a solution containing 10 μg per 1 ml, and obtain it.
[0087] 1.3 Sample extraction
[0088] Precisely weigh about 2.5 g of common decoction pieces of Rehmannia glutinosa (content of verbascoside 0.026% by weight) and superfine powder decoc...
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Abstract
The invention provides an ultrafine powder piece of prepared rehmannia root. The granularity of the ultrafine powder piece of prepared rehmannia root is 1-10mum, the quantity of bacteria contained in the piece does not exceed 10000cfu / g, and the quantity of moulds or microzymes contained in the piece does not exceed 100cfu / g. The invention also provides a preparation method of the ultrafine powder piece of prepared rehmannia root, and an application of the ultrafine powder piece of prepared rehmannia root. The ultrafine powder piece of prepared rehmannia root satisfies microbial limit requirements of oral solid medicines, and the component dissolution rate and the component leaching rate of the ultrafine powder piece are greatly higher than that of a traditional piece; the preparation method of the ultrafine powder piece of prepared rehmannia root needs no ultralow temperature treatment process, no extraction and no high temperature treatment process, and the crushing process does not cause component damage or removal, so the preparation method is suitable for the industrial production; and the preparation method of the piece of prepared rehmannia root can realize a disinfection effect, is a cold sterilization technology, avoids the destroys of a high temperature to traditional Chinese medicinal components, and avoids chemical gas and radiation pollution by killing bacteria through a physical method.
Description
technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to superfine powder decoction pieces of rehmannia glutinosa and its preparation method and application. Background technique [0002] Rehmannia glutinosa is processed by stewing or steaming the roots of Rehmannia glutinosa Libosch. Sweet in nature, slightly warm. Return liver, kidney channel. It has the effects of nourishing blood and nourishing yin, benefiting essence and filling marrow. For blood deficiency and chlorosis, palpitations, irregular menstruation, metrorrhagia, liver and kidney yin deficiency, soreness of the waist and knees, bone steaming and hot flashes, night sweats and nocturnal emission, internal heat quenching one's thirst, dizziness, tinnitus, premature graying of beard and hair. The main chemical components in Rehmannia glutinosa are polysaccharides, 5-hydroxymethylfurfural, amino acids, etc., which have pharmacological effects such as enhancing l...
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Application Information
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