Application of a delphinium extract in the preparation of anticancer drugs

A technology of delphinium and anticancer drugs, which is applied in the field of biomedicine and can solve the problems that have not yet been reported on the research on the anticancer effect of delphinium

Inactive Publication Date: 2015-12-09
尚希永
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The above-mentioned documents and patents, etc., have not yet seen reports on the research on the anticancer effect of delphinium or delphinium extract

Method used

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  • Application of a delphinium extract in the preparation of anticancer drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of delphinium extract

[0036] (1) 15kg of delphinium, crushed, sieved through a 30-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 45 ℃, extraction pressure 25MPa, extraction time 1.5h, extracting volatile oil, collecting volatile oil, that is the delphinium extract Material A, the dregs A after supercritical carbon dioxide extraction are standby;

[0037](2) Use the dregs A obtained in step (1) with 60% ethanol solution as the solvent, the extraction temperature is 70°C, the number of extractions is 2 times, each extraction time is 2.5 hours, and the amount of solvent used each time is Delphinium pilosula 12 times the weight; filter to obtain extract B and dregs B; extract B, recover ethanol, concentrate and dry to obtain Delphinium pilosula extract B;

[0038] (3) Use the dregs B obtained in step (2) as a solvent with a concentration of 3% hydrochloric acid solution, the extraction temperatur...

Embodiment 2

[0040] Embodiment 2: the preparation of delphinium extract

[0041] (1) 20kg of delphinium, crushed, passed through a 10-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 50 ℃, extraction pressure 20MPa, extraction time 2h, extract volatile oil, collect volatile oil, and obtain delphinium extract A, the medicinal residue A after supercritical carbon dioxide extraction is standby;

[0042] (2) Use the dregs A obtained in step (1) with 30% ethanol solution as a solvent, the extraction temperature is 95°C, the number of extractions is 1 time, the extraction time is 4 hours each time, and the amount of solvent used each time is Delphinium pilosula 15 times the weight; filter to obtain extract B and dregs B; extract B, recover ethanol, concentrate and dry to obtain Delphinium pilosula extract B;

[0043] (3) Use 5% hydrochloric acid solution as a solvent for the dregs B obtained in step (2), the extraction temperature is 60°C, the number ...

Embodiment 3

[0045] Embodiment 3: the preparation of delphinium extract

[0046] (1) 18kg delphinium, crushed, passed through a 50-mesh sieve, using supercritical carbon dioxide extraction technology, extraction temperature 40 ℃, extraction pressure 30MPa, extraction time 1h, extract volatile oil, collect volatile oil, and then get delphinium extract A, the medicinal residue A after supercritical carbon dioxide extraction is standby;

[0047] (2) Use the dregs A obtained in step (1) with 75% ethanol solution as a solvent, the extraction temperature is 50°C, the number of extractions is 3 times, each extraction time is 1 hour, and the amount of solvent used each time is Delphinium pilosula 6 times the weight; filter to obtain extract B and dregs B; extract B, recover ethanol, concentrate and dry to obtain Delphinium pilosula extract B;

[0048] (3) Use the dregs B obtained in step (2) with 1% hydrochloric acid solution as the solvent, the extraction temperature is 80°C, the number of extra...

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Abstract

The invention relates to new application of a herba delphinii extract in preparing anticancer drugs. The herba delphinii extract is prepared by: taking herba delphinii as a raw material, firstly extracting volatile oil, then conducting extraction with ethanol of different concentrations, and finally performing extraction with a low concentration hydrochloric acid water solution. The herba delphinii extract provided by the invention is of great significance in preparing anticancer drugs.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of an extract of Chinese medicinal materials in the preparation of anticancer drugs, in particular to the application of an extract of delphinium pilosa in the preparation of anticancer drugs. Background technique [0002] According to statistics from the Ministry of Health in February 2010, the number of cancer deaths worldwide reaches 10 million each year. At present, one-quarter of the global population's death is caused by cancer, and it is predicted that if the current trend continues, one-half of the deaths will be due to cancer by 2050. The incidence of malignant cancer in my country is increasing at a rate of 2.5-5% per year, and it has become the culprit that seriously endangers human life. Among various types of cancer, lung cancer, gastric cancer, and liver cancer have higher incidence rates. [0003] Blood vessels are necessary for the formation and function...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K9/20A61K9/16A61K9/48A61P35/00
Inventor 尚希永张绪坤
Owner 尚希永
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